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|---|---|---|
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| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2117852 URI |
| 024 | 7 | a https://doi.org/10.1038/ng.27952 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/42048442 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276841082 URI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-836272 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)kid (SwePub)umu | |
| 041 | a engb eng | |
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| 072 | 7 | a ref2 swepub-contenttype |
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| 100 | 1 | a Do, Ron4 aut |
| 245 | 1 0 | a Common variants associated with plasma triglycerides and risk for coronary artery disease |
| 264 | c 2013-10-06 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2013 |
| 338 | a print2 rdacarrier | |
| 520 | a Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 x 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 700 | 1 | a Willer, Cristen J.4 aut |
| 700 | 1 | a Schmidt, Ellen M.4 aut |
| 700 | 1 | a Sengupta, Sebanti4 aut |
| 700 | 1 | a Gao, Chi4 aut |
| 700 | 1 | a Peloso, Gina M.4 aut |
| 700 | 1 | a Gustafsson, Stefanu Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)stegu732 |
| 700 | 1 | a Kanoni, Stavroula4 aut |
| 700 | 1 | a Ganna, Andreau Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut |
| 700 | 1 | a Chen, Jin4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Mora, Samia4 aut |
| 700 | 1 | a Beckmann, Jacques S.4 aut |
| 700 | 1 | a Bragg-Gresham, Jennifer L.4 aut |
| 700 | 1 | a Chang, Hsing-Yi4 aut |
| 700 | 1 | a Demirkan, Ayse4 aut |
| 700 | 1 | a Den Hertog, Heleen M.4 aut |
| 700 | 1 | a Donnelly, Louise A.4 aut |
| 700 | 1 | a Ehret, Georg B.4 aut |
| 700 | 1 | a Esko, Tonu4 aut |
| 700 | 1 | a Feitosa, Mary F.4 aut |
| 700 | 1 | a Ferreira, Teresa4 aut |
| 700 | 1 | a Fischer, Krista4 aut |
| 700 | 1 | a Fontanillas, Pierre4 aut |
| 700 | 1 | a Fraser, Ross M.4 aut |
| 700 | 1 | a Freitag, Daniel F.4 aut |
| 700 | 1 | a Gurdasani, Deepti4 aut |
| 700 | 1 | a Heikkila, Kauko4 aut |
| 700 | 1 | a Hyppoenen, Elina4 aut |
| 700 | 1 | a Isaacs, Aaron4 aut |
| 700 | 1 | a Jackson, Anne U.4 aut |
| 700 | 1 | a Johansson, Åsau Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)asjoh108 |
| 700 | 1 | a Johnson, Toby4 aut |
| 700 | 1 | a Kaakinen, Marika4 aut |
| 700 | 1 | a Kettunen, Johannes4 aut |
| 700 | 1 | a Kleber, Marcus E.4 aut |
| 700 | 1 | a Li, Xiaohui4 aut |
| 700 | 1 | a Luan, Jian'an4 aut |
| 700 | 1 | a Lyytikainen, Leo-Pekka4 aut |
| 700 | 1 | a Magnusson, Patrik K. E.u Karolinska Institutet4 aut |
| 700 | 1 | a Mangino, Massimo4 aut |
| 700 | 1 | a Mihailov, Evelin4 aut |
| 700 | 1 | a Montasser, May E.4 aut |
| 700 | 1 | a Mueller-Nurasyid, Martina4 aut |
| 700 | 1 | a Nolte, Ilja M.4 aut |
| 700 | 1 | a O'Connell, Jeffrey R.4 aut |
| 700 | 1 | a Palmer, Cameron D.4 aut |
| 700 | 1 | a Perola, Markus4 aut |
| 700 | 1 | a Petersen, Ann-Kristin4 aut |
| 700 | 1 | a Sanna, Serena4 aut |
| 700 | 1 | a Saxena, Richa4 aut |
| 700 | 1 | a Service, Susan K.4 aut |
| 700 | 1 | a Shah, Sonia4 aut |
| 700 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003 |
| 700 | 1 | a Sidore, Carlo4 aut |
| 700 | 1 | a Song, Ciu Karolinska Institutet,Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ciaso492 |
| 700 | 1 | a Strawbridge, Rona J.u Karolinska Institutet4 aut |
| 700 | 1 | a Surakka, Ida4 aut |
| 700 | 1 | a Tanaka, Toshiko4 aut |
| 700 | 1 | a Teslovich, Tanya M.4 aut |
| 700 | 1 | a Thorleifsson, Gudmar4 aut |
| 700 | 1 | a Van den Herik, Evita G.4 aut |
| 700 | 1 | a Voight, Benjamin F.4 aut |
| 700 | 1 | a Volcik, Kelly A.4 aut |
| 700 | 1 | a Waite, Lindsay L.4 aut |
| 700 | 1 | a Wong, Andrew4 aut |
| 700 | 1 | a Wu, Ying4 aut |
| 700 | 1 | a Zhang, Weihua4 aut |
| 700 | 1 | a Absher, Devin4 aut |
| 700 | 1 | a Asiki, Gershim4 aut |
| 700 | 1 | a Barroso, Ines4 aut |
| 700 | 1 | a Been, Latonya F.4 aut |
| 700 | 1 | a Bolton, Jennifer L.4 aut |
| 700 | 1 | a Bonnycastle, Lori L.4 aut |
| 700 | 1 | a Brambilla, Paolo4 aut |
| 700 | 1 | a Burnett, Mary S.4 aut |
| 700 | 1 | a Cesana, Giancarlo4 aut |
| 700 | 1 | a Dimitriou, Maria4 aut |
| 700 | 1 | a Doney, Alex S. F.4 aut |
| 700 | 1 | a Doering, Angela4 aut |
| 700 | 1 | a Elliott, Paul4 aut |
| 700 | 1 | a Epstein, Stephen E.4 aut |
| 700 | 1 | a Eyjolfsson, Gudmundur Ingi4 aut |
| 700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
| 700 | 1 | a Goodarzi, Mark O.4 aut |
| 700 | 1 | a Grallert, Harald4 aut |
| 700 | 1 | a Gravito, Martha L.4 aut |
| 700 | 1 | a Groves, Christopher J.4 aut |
| 700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001 |
| 700 | 1 | a Hartikainen, Anna-Liisa4 aut |
| 700 | 1 | a Hayward, Caroline4 aut |
| 700 | 1 | a Hernandez, Dena4 aut |
| 700 | 1 | a Hicks, Andrew A.4 aut |
| 700 | 1 | a Holm, Hilma4 aut |
| 700 | 1 | a Hung, Yi-Jen4 aut |
| 700 | 1 | a Illig, Thomas4 aut |
| 700 | 1 | a Jones, Michelle R.4 aut |
| 700 | 1 | a Kaleebu, Pontiano4 aut |
| 700 | 1 | a Kastelein, John J. P.4 aut |
| 700 | 1 | a Khaw, Kay-Tee4 aut |
| 700 | 1 | a Kim, Eric4 aut |
| 700 | 1 | a Klopp, Norman4 aut |
| 700 | 1 | a Komulainen, Pirjo4 aut |
| 700 | 1 | a Kumari, Meena4 aut |
| 700 | 1 | a Langenberg, Claudia4 aut |
| 700 | 1 | a Lehtimaki, Terho4 aut |
| 700 | 1 | a Lin, Shih-Yi4 aut |
| 700 | 1 | a Lindstrom, Jaana4 aut |
| 700 | 1 | a Loos, Ruth J. F.4 aut |
| 700 | 1 | a Mach, Francois4 aut |
| 700 | 1 | a McArdle, Wendy L.4 aut |
| 700 | 1 | a Meisinger, Christa4 aut |
| 700 | 1 | a Mitchell, Braxton D.4 aut |
| 700 | 1 | a Mueller, Gabrielle4 aut |
| 700 | 1 | a Nagaraja, Ramaiah4 aut |
| 700 | 1 | a Narisu, Narisuu Karolinska Institutet4 aut |
| 700 | 1 | a Nieminen, Tuomo V. M.4 aut |
| 700 | 1 | a Nsubuga, Rebecca N.4 aut |
| 700 | 1 | a Olafsson, Isleifur4 aut |
| 700 | 1 | a Ong, Ken K.4 aut |
| 700 | 1 | a Palotie, Aarno4 aut |
| 700 | 1 | a Papamarkou, Theodore4 aut |
| 700 | 1 | a Pomilla, Cristina4 aut |
| 700 | 1 | a Pouta, Anneli4 aut |
| 700 | 1 | a Rader, Daniel J.4 aut |
| 700 | 1 | a Reilly, Muredach P.4 aut |
| 700 | 1 | a Ridker, Paul M.4 aut |
| 700 | 1 | a Rivadeneira, Fernando4 aut |
| 700 | 1 | a Rudan, Igor4 aut |
| 700 | 1 | a Ruokonen, Aimo4 aut |
| 700 | 1 | a Samani, Nilesh4 aut |
| 700 | 1 | a Scharnagl, Hubert4 aut |
| 700 | 1 | a Seeley, Janet4 aut |
| 700 | 1 | a Silander, Kaisa4 aut |
| 700 | 1 | a Stancakova, Alena4 aut |
| 700 | 1 | a Stirrups, Kathleen4 aut |
| 700 | 1 | a Swift, Amy J.4 aut |
| 700 | 1 | a Tiret, Laurence4 aut |
| 700 | 1 | a Uitterlinden, Andre G.4 aut |
| 700 | 1 | a van Pelt, L. Joost4 aut |
| 700 | 1 | a Vedantam, Sailaja4 aut |
| 700 | 1 | a Wainwright, Nicholas4 aut |
| 700 | 1 | a Wijmenga, Cisca4 aut |
| 700 | 1 | a Wild, Sarah H.4 aut |
| 700 | 1 | a Willemsen, Gonneke4 aut |
| 700 | 1 | a Wilsgaard, Tom4 aut |
| 700 | 1 | a Wilson, James F.4 aut |
| 700 | 1 | a Young, Elizabeth H.4 aut |
| 700 | 1 | a Zhao, Jing Hua4 aut |
| 700 | 1 | a Adair, Linda S.4 aut |
| 700 | 1 | a Arveiler, Dominique4 aut |
| 700 | 1 | a Assimes, Themistocles L.4 aut |
| 700 | 1 | a Bandinelli, Stefania4 aut |
| 700 | 1 | a Bennett, Franklyn4 aut |
| 700 | 1 | a Bochud, Murielle4 aut |
| 700 | 1 | a Boehm, Bernhard O.4 aut |
| 700 | 1 | a Boomsma, Dorret I.4 aut |
| 700 | 1 | a Borecki, Ingrid B.4 aut |
| 700 | 1 | a Bornstein, Stefan R.4 aut |
| 700 | 1 | a Bovet, Pascal4 aut |
| 700 | 1 | a Burnier, Michel4 aut |
| 700 | 1 | a Campbell, Harry4 aut |
| 700 | 1 | a Chakravarti, Aravinda4 aut |
| 700 | 1 | a Chambers, John C.4 aut |
| 700 | 1 | a Chen, Yii-Der Ida4 aut |
| 700 | 1 | a Collins, Francis S.4 aut |
| 700 | 1 | a Cooper, Richard S.4 aut |
| 700 | 1 | a Danesh, John4 aut |
| 700 | 1 | a Dedoussis, George4 aut |
| 700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
| 700 | 1 | a Feranil, Alan B.4 aut |
| 700 | 1 | a Ferrieres, Jean4 aut |
| 700 | 1 | a Ferrucci, Luigi4 aut |
| 700 | 1 | a Freimer, Nelson B.4 aut |
| 700 | 1 | a Gieger, Christian4 aut |
| 700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
| 700 | 1 | a Gudnason, Vilmundur4 aut |
| 700 | 1 | a Gyllensten, Ulfu Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)4 aut0 (Swepub:uu)ulfgyll |
| 700 | 1 | a Hamsten, Andersu Karolinska Institutet4 aut |
| 700 | 1 | a Harris, Tamara B.4 aut |
| 700 | 1 | a Hingorani, Aroon4 aut |
| 700 | 1 | a Hirschhorn, Joel N.4 aut |
| 700 | 1 | a Hofman, Albert4 aut |
| 700 | 1 | a Hovingh, G. Kees4 aut |
| 700 | 1 | a Hsiung, Chao Agnes4 aut |
| 700 | 1 | a Humphries, Steve E.4 aut |
| 700 | 1 | a Hunt, Steven C.4 aut |
| 700 | 1 | a Hveem, Kristian4 aut |
| 700 | 1 | a Iribarren, Carlos4 aut |
| 700 | 1 | a Jarvelin, Marjo-Riitta4 aut |
| 700 | 1 | a Jula, Antti4 aut |
| 700 | 1 | a Kahonen, Mika4 aut |
| 700 | 1 | a Kaprio, Jaakko4 aut |
| 700 | 1 | a Kesaniemi, Antero4 aut |
| 700 | 1 | a Kivimaki, Mika4 aut |
| 700 | 1 | a Kooner, Jaspal S.4 aut |
| 700 | 1 | a Koudstaal, Peter J.4 aut |
| 700 | 1 | a Krauss, Ronald M.4 aut |
| 700 | 1 | a Kuh, Diana4 aut |
| 700 | 1 | a Kuusisto, Johanna4 aut |
| 700 | 1 | a Kyvik, Kirsten O.4 aut |
| 700 | 1 | a Laakso, Markku4 aut |
| 700 | 1 | a Lakka, Timo A.4 aut |
| 700 | 1 | a Lind, Larsu Uppsala universitet,Kardiovaskulär epidemiologi4 aut0 (Swepub:uu)larslind |
| 700 | 1 | a Lindgren, Cecilia M.4 aut |
| 700 | 1 | a Martin, Nicholas G.4 aut |
| 700 | 1 | a Maerz, Winfried4 aut |
| 700 | 1 | a McCarthy, Mark I.4 aut |
| 700 | 1 | a McKenzie, Colin A.4 aut |
| 700 | 1 | a Meneton, Pierre4 aut |
| 700 | 1 | a Metspalu, Andres4 aut |
| 700 | 1 | a Moilanen, Leena4 aut |
| 700 | 1 | a Morris, Andrew D.4 aut |
| 700 | 1 | a Munroe, Patricia B.4 aut |
| 700 | 1 | a Njolstad, Inger4 aut |
| 700 | 1 | a Pedersen, Nancy L.4 aut |
| 700 | 1 | a Power, Chris4 aut |
| 700 | 1 | a Pramstaller, Peter P.4 aut |
| 700 | 1 | a Price, Jackie F.4 aut |
| 700 | 1 | a Psaty, Bruce M.4 aut |
| 700 | 1 | a Quertermous, Thomas4 aut |
| 700 | 1 | a Rauramaa, Rainer4 aut |
| 700 | 1 | a Saleheen, Danish4 aut |
| 700 | 1 | a Salomaa, Veikko4 aut |
| 700 | 1 | a Sanghera, Dharambir K.4 aut |
| 700 | 1 | a Saramies, Jouko4 aut |
| 700 | 1 | a Schwarz, Peter E. H.4 aut |
| 700 | 1 | a Sheu, Wayne H-H4 aut |
| 700 | 1 | a Shuldiner, Alan R.4 aut |
| 700 | 1 | a Siegbahn, Agnetau Uppsala universitet,Molekylär epidemiologi,Uppsala kliniska forskningscentrum (UCR),Koagulation och inflammationsvetenskap4 aut0 (Swepub:uu)agsie424 |
| 700 | 1 | a Spector, Tim D.4 aut |
| 700 | 1 | a Stefansson, Kari4 aut |
| 700 | 1 | a Strachan, David P.4 aut |
| 700 | 1 | a Tayo, Bamidele O.4 aut |
| 700 | 1 | a Tremoli, Elena4 aut |
| 700 | 1 | a Tuomilehto, Jaakko4 aut |
| 700 | 1 | a Uusitupa, Matti4 aut |
| 700 | 1 | a van Duijn, Cornelia M.4 aut |
| 700 | 1 | a Vollenweider, Peter4 aut |
| 700 | 1 | a Wallentin, Larsu Uppsala universitet,Kardiologi4 aut0 (Swepub:uu)larswall |
| 700 | 1 | a Wareham, Nicholas J.4 aut |
| 700 | 1 | a Whitfield, John B.4 aut |
| 700 | 1 | a Wolffenbuttel, Bruce H. R.4 aut |
| 700 | 1 | a Altshuler, David4 aut |
| 700 | 1 | a Ordovas, Jose M.4 aut |
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| 700 | 1 | a Thorsteinsdottir, Unnur4 aut |
| 700 | 1 | a Chasman, Daniel I.4 aut |
| 700 | 1 | a Rotter, Jerome I.4 aut |
| 700 | 1 | a Franks, Paulu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Lunds universitet, Harvard University4 aut0 (Swepub:umu)pafr0003 |
| 700 | 1 | a Ripatti, Samuli4 aut |
| 700 | 1 | a Cupples, L. Adrienne4 aut |
| 700 | 1 | a Sandhu, Manjinder S.4 aut |
| 700 | 1 | a Rich, Stephen S.4 aut |
| 700 | 1 | a Boehnke, Michael4 aut |
| 700 | 1 | a Deloukas, Panos4 aut |
| 700 | 1 | a Mohlke, Karen L.4 aut |
| 700 | 1 | a Ingelsson, Eriku Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)ering425 |
| 700 | 1 | a Abecasis, Goncalo R.4 aut |
| 700 | 1 | a Daly, Mark J.4 aut |
| 700 | 1 | a Neale, Benjamin M.4 aut |
| 700 | 1 | a Kathiresan, Sekar4 aut |
| 710 | 2 | a Uppsala universitetb Molekylär epidemiologi4 org |
| 773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 45:11, s. 1345-+q 45:11<1345-+x 1061-4036x 1546-1718 |
| 856 | 4 | u https://europepmc.org/articles/pmc3904346?pdf=render |
| 856 | 4 | u http://dx.doi.org/10.1038/ng.2795y FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-211785 |
| 856 | 4 8 | u https://doi.org/10.1038/ng.2795 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/4204844 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:127684108 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-83627 |
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