Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population.

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Prediction of diabetes with body mass index, oral glucose tolerance test and islet cell autoantibodies in a regional population.

Rolandsson, O (author)

Hägg, Erik (author): Umeå universitet,Medicin

Nilsson, M (author)

Hallmans, G (author)

Mincheva-Nilsson, Lucia (author): Umeå universitet,Klinisk immunologi,Institutionen för klinisk mikrobiologi

Lernmark, A (author)

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(creator_code:org_t)

2001
2001
English.
In: Journal of Internal Medicine. - 0954-6820 .- 1365-2796. ; 249:4, s. 279-88

Related links:: https://urn.kb.se/re...

Journal article (peer-reviewed)

Abstract Subject headings

OBJECTIVE: Our aim was to test the hypothesis that a combination of markers for Type 1 diabetes (glutamate decarboxylase and IA-2 autoantibodies) and for Type 2 diabetes [oral glucose tolerance test (OGTT) and body mass index (BMI)], would predict clinical diabetes in a regional population. DESIGN: A population-based follow-up cohort study. SETTING: Participants visited the primary health care centre in Lycksele, Sweden in 1988-92. PARTICIPANTS: A cohort of 2278 subjects (M/F 1149/1129) who were studied at follow-up in 1998. At base line there were 2314 subjects (M/F 1167/1147) who participated in the Västerbotten Intervention Program on their birthday when turning either 30, 40, 50 or 60 years of age. Main outcome measurements. A clinically diagnosed diabetes at follow-up when the medical records were reviewed for diagnosis of diabetes. At base line, the participants were subjected to a standard OGTT and their BMI determined along with the autoantibodies. RESULTS: At follow-up, 42/2278 (1.8%, 95% CI 1.2-2.3) (M/F 23/19) had developed diabetes: 41 subjects were clinically classified with Type 2 and one with Type 1 diabetes. There was no significant relation between autoantibody levels at base line and diabetes at follow-up. Stepwise multiple logistic regression showed that the odds ratio for developing diabetes was 10.8 (95% CI 6.3-18.9) in subjects in the fourth quartile of BMI (BMI > 27) compared with 7.8 (95% CI 4.8-12.6) in the fourth quartile of 2-h plasma glucose (>7.5 mmol L(-1)) and 7.2 (95% CI 4.8-11.4) in the fourth quartile of the fasting plasma glucose (>5.6 mmol L(-1)). CONCLUSION: Islet cell autoantibodies did not predict diabetes at follow-up. BMI measured at base line was as effective as 2-h plasma glucose and fasting plasma glucose to predict diabetes in this adult population.

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By the author/editor: Rolandsson, O; Hägg, Erik; Nilsson, M; Hallmans, G; Mincheva-Nilsson ...; Lernmark, A

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