SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Rosendahl Ann H.)
 

Sökning: WFRF:(Rosendahl Ann H.) > (2015-2019) > Long-term exposure ...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005659naa a2200493 4500
001oai:lup.lub.lu.se:b1d13494-9bc9-42de-ade2-f002031c136f
003SwePub
008181105s2018 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:138911374
0247 a https://lup.lub.lu.se/record/b1d13494-9bc9-42de-ade2-f002031c136f2 URI
0247 a https://doi.org/10.1186/s13058-018-1026-72 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1389113742 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Borgquist, Signeu Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)ront-sbo
2451 0a Long-term exposure to insulin and volumetric mammographic density : Observational and genetic associations in the Karma study
264 c 2018-08-09
264 1b Springer Science and Business Media LLC,c 2018
520 a Background: Long-term insulin exposure has been implicated in breast cancer etiology, but epidemiological evidence remains inconclusive. The aims of this study were to investigate the association of insulin therapy with mammographic density (MD) as an intermediate phenotype for breast cancer and to assess associations with long-term elevated circulating insulin levels using a genetic score comprising 18 insulin-associated variants. Methods: We used data from the KARolinska MAmmography (Karma) project, a Swedish mammography screening cohort. Insulin-treated patients with type 1 (T1D, n = 122) and type 2 (T2D, n = 237) diabetes were identified through linkage with the Prescribed Drug Register and age-matched to 1771 women without diabetes. We assessed associations with treatment duration and insulin glargine use, and we further examined MD differences using non-insulin-treated T2D patients as an active comparator. MD was measured using a fully automated volumetric method, and analyses were adjusted for multiple potential confounders. Associations with the insulin genetic score were assessed in 9437 study participants without diabetes. Results: Compared with age-matched women without diabetes, insulin-treated T1D patients had greater percent dense (8.7% vs. 11.4%) and absolute dense volumes (59.7 vs. 64.7 cm3), and a smaller absolute nondense volume (615 vs. 491 cm3). Similar associations were observed for insulin-treated T2D, and estimates were not materially different in analyses comparing insulin-treated T2D patients with T2D patients receiving noninsulin glucose-lowering medication. In both T1D and T2D, the magnitude of the association with the absolute dense volume was highest for long-term insulin therapy (≥ 5 years) and the long-acting insulin analog glargine. No consistent evidence of differential associations by insulin treatment duration or type was found for percent dense and absolute nondense volumes. Genetically predicted insulin levels were positively associated with percent dense and absolute dense volumes, but not with the absolute nondense volume (percentage difference [95% CI] per 1-SD increase in insulin genetic score = 0.8 [0.0; 1.6], 0.9 [0.1; 1.8], and 0.1 [- 0.8; 0.9], respectively). Conclusions: The consistency in direction of association for insulin treatment and the insulin genetic score with the absolute dense volume suggest a causal influence of long-term increased insulin exposure on mammographic dense breast tissue.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng
653 a Breast cancer
653 a Diabetes
653 a Insulin
653 a Insulin genetic score
653 a Mammographic density
7001 a Rosendahl, Ann H.u Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,Breast cancer prevention & intervention,Lund University Research Groups4 aut0 (Swepub:lu)onk-aro
7001 a Czene, Kamilau Karolinska Institutet,Karolinska Institute4 aut
7001 a Bhoo-Pathy, Nirmalau University of Malaya4 aut
7001 a Dorkhan, Mozhganu Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Novo Nordisk A/S4 aut0 (Swepub:lu)endo-mdo
7001 a Hall, Peru Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital4 aut
7001 a Brand, Judith S.u Örebro University,Karolinska Institute4 aut
7102 a Bröstcancer - prevention & interventionb Forskargrupper vid Lunds universitet4 org
7730 t Breast Cancer Researchd : Springer Science and Business Media LLCg 20:1q 20:1x 1465-5411x 1465-542X
8564 u http://dx.doi.org/10.1186/s13058-018-1026-7x freey FULLTEXT
8564 u https://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-018-1026-7
8564 8u https://lup.lub.lu.se/record/b1d13494-9bc9-42de-ade2-f002031c136f
8564 8u https://doi.org/10.1186/s13058-018-1026-7
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:138911374

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy