SwePub
Tyck till om SwePub Sök här!
Sök i LIBRIS databas

  Extended search

WFRF:(Scheele Camilla)
 

Search: WFRF:(Scheele Camilla) > Human brown adipose...

Human brown adipose tissue is phenocopied by classical brown adipose tissue in physiologically humanized mice

de Jong, Jasper M. A. (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Yale School of Medicine, USA,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.;Yale Sch Med, Dept Comparat Med, New Haven, CT USA.
Sun, Wenfei (author)
Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland.
Pires, Nuno D. (author)
show more...
Frontini, Andrea (author)
Univ Pavia, Dept Publ Hlth Expt & Forens Med, Pavia, Italy.
Balaz, Miroslav (author)
Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland.
Jespersen, Naja Z. (author)
Univ Hosp Copenhagen, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.;Univ Hosp Copenhagen, Ctr Phys Activ Res, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Feizi, Amir (author)
Novo Nordisk Res Ctr Oxford, Oxford, England.
Petrovic, Katarina (author)
KTH,Kemi
Fischer, Alexander W. (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,University Medical Center Hamburg-Eppendorf, Germany; Chan School of Public Health, USA; Harvard Medical School, USA,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.;Univ Med Ctr Hamburg Eppendorf, Dept Biochem & Mol Cell Biol, Hamburg, Germany.;Harvard TH Chan Sch Publ Hlth, Dept Genet & Complex Dis, Boston, MA USA.;Harvard Med Sch, Dept Cell Biol, Boston, MA 02115 USA.
Bokhari, Muhammad Hamza (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Niemi, Tarja (author)
Turku Univ Hosp, Dept Surg, Turku, Finland.
Nuutila, Pirjo (author)
Cinti, Saverio (author)
Univ Ancona, Dept Expt & Clin Med, Ancona, Italy.
Nielsen, Soren (author)
Scheele, Camilla (author)
Univ Hosp Copenhagen, Ctr Inflammat & Metab, Rigshosp, Copenhagen, Denmark.;Univ Hosp Copenhagen, Ctr Phys Activ Res, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Virtanen, Kirsi (author)
Univ Turku, Turku PET Ctr, Turku, Finland.
Cannon, Barbara (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
Nedergaard, Jan (author)
Wolfrum, Christian (author)
Eidgenoss Tech Hsch Zurich, Inst Food Nutr & Hlth, Schwerzenbach, Switzerland.
Petrovic, Natasa (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut,Stockholm Univ, Wenner Gren Inst, Dept Mol Biosci, Stockholm, Sweden.
show less...
 (creator_code:org_t)
2019-08-19
2019
English.
In: Nature Metabolism. - : Springer Science and Business Media LLC. - 2522-5812. ; 1:8, s. 830-843
Related links:
https://urn.kb.se/re...
show more...
https://doi.org/10.1...
https://urn.kb.se/re...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Human and rodent brown adipose tissues (BAT) appear morphologically and molecularly different. Here we compare human BAT with both classical brown and brite/beige adipose tissues of 'physiologically humanized' mice: middle-aged mice living under conditions approaching human thermal and nutritional conditions, that is, prolonged exposure to thermoneutral temperature (approximately 30 degrees C) and to an energy-rich (high-fat, high-sugar) diet. We find that the morphological, cellular and molecular characteristics (both marker and adipose-selective gene expression) of classical brown fat, but not of brite/beige fat, of these physiologically humanized mice are notably similar to human BAT. We also demonstrate, both in silico and experimentally, that in physiologically humanized mice only classical BAT possesses a high thermogenic potential. These observations suggest that classical rodent BAT is the tissue of choice for translational studies aimed at recruiting human BAT to counteract the development of obesity and its comorbidities.

Subject headings

NATURVETENSKAP  -- Biologi -- Cellbiologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Cell Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Physiology (hsv//eng)
NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view