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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04449naa a2200673 4500 | |
| 001 | oai:gup.ub.gu.se/243661 | |
| 003 | SwePub | |
| 008 | 240528s2016 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/2436612 URI |
| 024 | 7 | a https://doi.org/10.1136/bmjopen-2016-0115842 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Meulenbroek, O.4 aut |
| 245 | 1 0 | a European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer's disease - The substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow |
| 264 | c 2016-07-19 | |
| 264 | 1 | b BMJ,c 2016 |
| 520 | a Introduction: In conjunction with the NILVAD trial, a European Multicentre Double-Blind Placebo Controlled trial of Nilvadipine in Mild-to-Moderate Alzheimer's disease (AD), there are four NILVAD substudies in which eligible NILVAD patients are also invited to participate. The main NILVAD protocol was previously published in BMJ Open (2014). The objectives of the NILVAD substudies are to determine whether frailty, cerebrospinal fluid (CSF), blood biomarker profile and Apolipoprotein E (APOE) status predict response to Nilvadipine, and to investigate the effect of Nilvadipine on cerebral blood flow and blood biomarkers. Methods and analysis: All participants who fulfil criteria for the main NILVAD study are eligible for participation in the NILVAD substudies. Participation is subject to informed consent and whether the substudy is available at a particular NILVAD study site. Each substudy entails extra measurements during the course of the main NILVAD study. For example, in the blood and genetic biomarkers substudy, extra blood (30 mL) will be collected at week 0, week 13, week 52 and week 78, while in the cerebral blood flow substudy, participants will receive an MRI and transcranial Doppler measurements at week 0, week 26 and week 78. In the CSF substudy, 10 mL CSF is collected at week 0 and week 78. Ethics and dissemination: All NILVAD substudies and all subsequent amendments have received ethical approval within each participating country, according to national regulations. Each participant provides written consent to participate. All participants remain anonymised throughout and the results of each substudy will be published in an international peer reviewed journal. © 2016 Published by the BMJ Publishing Group Limited. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Medicinsk etik0 (SwePub)303102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Medical Ethics0 (SwePub)303102 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng |
| 653 | a GERIATRIC MEDICINE | |
| 653 | a NEUROLOGY | |
| 700 | 1 | a O'Dwyer, S.4 aut |
| 700 | 1 | a De Jong, D.4 aut |
| 700 | 1 | a Van Spijker, G.4 aut |
| 700 | 1 | a Kennelly, S.4 aut |
| 700 | 1 | a Cregg, F.4 aut |
| 700 | 1 | a Rikkert, M. O.4 aut |
| 700 | 1 | a Abdullah, L.4 aut |
| 700 | 1 | a Wallin, Anders,d 1950u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology4 aut0 (Swepub:gu)xwaand |
| 700 | 1 | a Walsh, C.4 aut |
| 700 | 1 | a Coen, R.4 aut |
| 700 | 1 | a Kenny, R. A.4 aut |
| 700 | 1 | a Daly, L.4 aut |
| 700 | 1 | a Segurado, R.4 aut |
| 700 | 1 | a Borjesson-Hanson, A.4 aut |
| 700 | 1 | a Crawford, F.4 aut |
| 700 | 1 | a Mullan, M.4 aut |
| 700 | 1 | a Lucca, U.4 aut |
| 700 | 1 | a Banzi, R.4 aut |
| 700 | 1 | a Pasquier, F.4 aut |
| 700 | 1 | a Breuilh, L.4 aut |
| 700 | 1 | a Riepe, M.4 aut |
| 700 | 1 | a Kalman, J.4 aut |
| 700 | 1 | a Molloy, W.4 aut |
| 700 | 1 | a Tsolaki, M.4 aut |
| 700 | 1 | a Howard, R.4 aut |
| 700 | 1 | a Jessica Adams, M. O.4 aut |
| 700 | 1 | a Gaynor, S.4 aut |
| 700 | 1 | a Lawlor, B.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi4 org |
| 773 | 0 | t BMJ Opend : BMJg 6:7q 6:7x 2044-6055 |
| 856 | 4 | u https://bmjopen.bmj.com/content/bmjopen/6/7/e011584.full.pdf |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/243661 |
| 856 | 4 8 | u https://doi.org/10.1136/bmjopen-2016-011584 |
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