Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines

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Fältnamn	Indikatorer	Metadata
000		03336naa a2200505 4500
001		oai:DiVA.org:uu-255057
003		SwePub
008		150612s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:131235682
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2550572 URI
024	7	a https://doi.org/10.1007/s13361-015-1119-92 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1312356822 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Shariatgorji, Mohammadreza4 aut
245	1 0	a Pyrylium Salts as Reactive Matrices for MALDI-MS Imaging of Biologically Active Primary Amines
264		c 2015-03-28
264	1	b American Chemical Society (ACS),c 2015
338		a print2 rdacarrier
520		a Many neuroactive substances, including endogenous biomolecules, environmental compounds, and pharmaceuticals possess primary amine functional groups. Among these are catecholamine neurotransmitters (e.g., dopamine), many substituted phenethylamines (e.g., amphetamine), as well as amino acids and neuropeptides. In most cases, mass spectrometric (ESI and MALDI) analyses of trace amounts of such compounds are challenging because of their poor ionization properties. We present a method for chemical derivatization of primary amines by reaction with pyrylium salts that facilitates their detection by MALDI-MS and enables the imaging of primary amines in brain tissue sections. A screen of pyrylium salts revealed that the 2,4-diphenyl-pyranylium ion efficiently derivatizes primary amines and can be used as a reactive MALDI-MS matrix that induces both derivatization and desorption. MALDI-MS imaging with such matrix was used to map the localization of dopamine and amphetamine in brain tissue sections and to quantitatively map the distribution of the neurotoxin beta-N-methylamino-L-alanine.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653		a MALDI matrix
653		a Mass spectrometry imaging
653		a Neurotransmitter
653		a Catecholamine
653		a Phenethylamine
653		a Amphetamine
653		a Primary amine
653		a Reactive matrix
653		a Neurotoxin
700	1	a Nilsson, Anna4 aut
700	1	a Kallback, Patrik4 aut
700	1	a Karlsson, Oskaru Karolinska Institutet,Uppsala universitet,Institutionen för farmaceutisk biovetenskap4 aut0 (Swepub:uu)oskar255
700	1	a Zhang, Xiaoqunu Karolinska Institutet4 aut
700	1	a Svenningsson, Peru Karolinska Institutet4 aut
700	1	a Andren, Per E.4 aut
710	2	a Uppsala universitetb Institutionen för farmaceutisk biovetenskap4 org
773	0	t Journal of the American Society for Mass Spectrometryd : American Chemical Society (ACS)g 26:6, s. 934-939q 26:6<934-939x 1044-0305x 1879-1123
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255057
856	4 8	u https://doi.org/10.1007/s13361-015-1119-9
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:131235682

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Av författaren/redakt...: Shariatgorji, Mo ...; Nilsson, Anna; Kallback, Patrik; Karlsson, Oskar; Zhang, Xiaoqun; Svenningsson, Pe ...; visa fler...; Andren, Per E.; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmaceutiska ve ...

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Av lärosätet: Uppsala universitet; Karolinska Institutet

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