Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia

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Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia

Thastrup, Maria (author): Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.

Marquart, Hanne Vibeke (author): Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.

Levinsen, Mette (author): Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.

Modvig, Signe (author): Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark.

Abrahamsson, Jonas (author): Sahlgrens Univ Hosp, Inst Clin Sci, Dept Paediat, Gothenburg, Sweden.

Albertsen, Birgitte Klug (author): Aarhus Univ Hosp, Children & Adolescent Hlth, Aarhus, Denmark.

Frost, Britt-Marie (author)

Harila-Saari, Arja H. (author): Uppsala universitet,Barnonkologisk och neurologisk forskning

Pesola, Jouni (author): Kuopio Univ Hosp, Paediat Haematol & Oncol Unit, Kuopio, Finland.

Ulvmoen, Aina (author): Oslo Univ Hosp, Dept Paediat, Oslo, Norway.

Wojcik, Dorota Malgorzata (author): Haukeland Hosp, Childrens Clin, Bergen, Norway.

Taskinen, Mervi (author): Helsinki Univ Hosp, Div Paediat Haematol Oncol & Stem Cell Transplant, Children & Adolescents, Helsinki, Finland.

Hoffmann, Marianne (author): Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.

Lausen, Birgitte (author): Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.

Schmiegelow, Kjeld (author): Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Hlth & Med Sci, Copenhagen, Denmark.

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Univ Copenhagen, Rigshosp, Dept Paediat & Adolescent Med, Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Clin Immunol, Copenhagen, Denmark. (creator_code:org_t)

2021-08-15
2021
English.
In: British Journal of Haematology. - : John Wiley & Sons. - 0007-1048 .- 1365-2141. ; 195:1, s. 119-122

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Infants with acute lymphoblastic leukaemia (ALL) have a high frequency of central nervous system (CNS) involvement. Flow cytometric analysis of cerebrospinal fluid (CSF) was recently demonstrated to be a sensitive method for detecting CNS involvement in childhood ALL. In the present study, CSF from 14 infants was collected at routine lumbar punctures and analysed by multicolour flow cytometry. At initial diagnosis, leukaemic blasts were detected in CSF by flow cytometry in 11 patients (78 center dot 6%) compared to seven patients (50%) by cytospin. Larger studies are needed to determine if CSF flow cytometry has prognostic value in infant ALL.

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By the author/editor: Thastrup, Maria; Marquart, Hanne ...; Levinsen, Mette; Modvig, Signe; Abrahamsson, Jon ...; Albertsen, Birgi ...; show more...; Frost, Britt-Mar ...; Harila-Saari, Ar ...; Pesola, Jouni; Ulvmoen, Aina; Wojcik, Dorota M ...; Taskinen, Mervi; Hoffmann, Marian ...; Lausen, Birgitte; Schmiegelow, Kje ...; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Hematology

Articles in the publication: British Journal ...

By the university: Uppsala University

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Flow cytometric analysis of cerebrospinal fluid improves detection of leukaemic blasts in infants with acute lymphoblastic leukaemia

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