Search: WFRF:(Teixeira Pedro Filipe) >
Amyloid-beta Peptid...
Amyloid-beta Peptide Induces Mitochondrial Dysfunction by Inhibition of Preprotein Maturation
-
Mossmann, Dirk (author)
-
Voegtle, F-Nora (author)
-
Taskin, Asli Aras (author)
-
show more...
-
- Teixeira, Pedro Filipe (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
Ring, Julia (author)
-
Burkhart, Julia M. (author)
-
Burger, Nils (author)
-
- Pinho, Catarina Moreira (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
Tadic, Jelena (author)
-
Loreth, Desiree (author)
-
- Graff, Caroline (author)
- Karolinska Institutet
-
Metzger, Friedrich (author)
-
Sickmann, Albert (author)
-
Kretz, Oliver (author)
-
Wiedemann, Nils (author)
-
Zahedi, Rene P. (author)
-
Madeo, Frank (author)
-
- Glaser, Elzbieta (author)
- Stockholms universitet,Institutionen för biokemi och biofysik
-
Meisinger, Chris (author)
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- English.
-
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 20:4, s. 662-669
- Related links:
-
http://www.cell.com/...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Most mitochondrial proteins possess N-terminal presequences that are required for targeting and import into the organelle. Upon import, presequences are cleaved off by matrix processing peptidases and subsequently degraded by the peptidasome Cym1/PreP, which also degrades Amyloid-beta peptides (A beta). Here we find that impaired turnover of presequence peptides results in feedback inhibition of presequence processing enzymes. Moreover, A beta inhibits degradation of presequence peptides by PreP, resulting in accumulation of mitochondrial preproteins and processing intermediates. Dysfunctional preprotein maturation leads to rapid protein degradation and an imbalanced organellar proteome. Our findings reveal a general mechanism by which A beta peptide can induce the multiple diverse mitochondrial dysfunctions accompanying Alzheimer's disease.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Mossmann, Dirk
-
Voegtle, F-Nora
-
Taskin, Asli Ara ...
-
Teixeira, Pedro ...
-
Ring, Julia
-
Burkhart, Julia ...
-
show more...
-
Burger, Nils
-
Pinho, Catarina ...
-
Tadic, Jelena
-
Loreth, Desiree
-
Graff, Caroline
-
Metzger, Friedri ...
-
Sickmann, Albert
-
Kretz, Oliver
-
Wiedemann, Nils
-
Zahedi, Rene P.
-
Madeo, Frank
-
Glaser, Elzbieta
-
Meisinger, Chris
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
- Articles in the publication
-
Cell Metabolism
- By the university
-
Stockholm University
-
Karolinska Institutet