Sökning: WFRF:(Tian J) > (2020-2024) > Genome-wide analysi...
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000 | 08310naa a2201909 4500 | |
001 | oai:gup.ub.gu.se/315468 | |
003 | SwePub | |
008 | 240528s2021 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:eaed7d99-033e-4549-9b96-66d4ef218fbe | |
009 | oai:prod.swepub.kib.ki.se:148200898 | |
024 | 7 | a https://gup.ub.gu.se/publication/3154682 URI |
024 | 7 | a https://doi.org/10.1038/s41588-021-00950-82 DOI |
024 | 7 | a https://lup.lub.lu.se/record/eaed7d99-033e-4549-9b96-66d4ef218fbe2 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1482008982 URI |
040 | a (SwePub)gud (SwePub)lud (SwePub)ki | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Eijsbouts, C.u University of Oxford4 aut |
245 | 1 0 | a Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders |
264 | c 2021-11-05 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe panel (205,252 cases and 1,384,055 controls). Our study identified and confirmed six genetic susceptibility loci for IBS. Implicated genes included NCAM1, CADM2, PHF2/FAM120A, DOCK9, CKAP2/TPTE2P3 and BAG6. The first four are associated with mood and anxiety disorders, expressed in the nervous system, or both. Mirroring this, we also found strong genome-wide correlation between the risk of IBS and anxiety, neuroticism and depression (rg > 0.5). Additional analyses suggested this arises due to shared pathogenic pathways rather than, for example, anxiety causing abdominal symptoms. Implicated mechanisms require further exploration to help understand the altered brain–gut interactions underlying IBS. © 2021, The Author(s). | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng |
700 | 1 | a Zheng, T.4 aut |
700 | 1 | a Kennedy, N. A.4 aut |
700 | 1 | a Bonfiglio, F.u Karolinska Institutet4 aut |
700 | 1 | a Anderson, C. A.4 aut |
700 | 1 | a Moutsianas, L.4 aut |
700 | 1 | a Holliday, J.4 aut |
700 | 1 | a Shi, J.4 aut |
700 | 1 | a Shringarpure, S.4 aut |
700 | 1 | a Agee, M.4 aut |
700 | 1 | a Aslibekyan, S.4 aut |
700 | 1 | a Auton, A.4 aut |
700 | 1 | a Bell, R. K.4 aut |
700 | 1 | a Bryc, K.4 aut |
700 | 1 | a Clark, S. K.4 aut |
700 | 1 | a Elson, S. L.4 aut |
700 | 1 | a Fletez-Brant, K.4 aut |
700 | 1 | a Fontanillas, P.4 aut |
700 | 1 | a Furlotte, N. A.4 aut |
700 | 1 | a Gandhi, P. M.u University of Cambridge,Cambridge University Hospitals NHS Foundation Trust4 aut |
700 | 1 | a Heilbron, K.4 aut |
700 | 1 | a Hicks, B.4 aut |
700 | 1 | a Hinds, D. A.4 aut |
700 | 1 | a Huber, K. E.4 aut |
700 | 1 | a Jewett, E. M.4 aut |
700 | 1 | a Jiang, Y.4 aut |
700 | 1 | a Kleinman, A.4 aut |
700 | 1 | a Lin, K. H.4 aut |
700 | 1 | a Litterman, N. K.4 aut |
700 | 1 | a Luff, M. K.4 aut |
700 | 1 | a McCreight, J. C.4 aut |
700 | 1 | a McIntyre, M. H.4 aut |
700 | 1 | a McManus, K. F.4 aut |
700 | 1 | a Mountain, J. L.u University of Oxford4 aut |
700 | 1 | a Mozaffari, S. V.4 aut |
700 | 1 | a Nandakumar, P.4 aut |
700 | 1 | a Noblin, E. S.4 aut |
700 | 1 | a Northover, C. A. M.4 aut |
700 | 1 | a O’Connell, J.4 aut |
700 | 1 | a Petrakovitz, A. A.4 aut |
700 | 1 | a Pitts, S. J.4 aut |
700 | 1 | a Poznik, G. D.4 aut |
700 | 1 | a Sathirapongsasuti, J. F.4 aut |
700 | 1 | a Shastri, A. J.4 aut |
700 | 1 | a Shelton, J. F.4 aut |
700 | 1 | a Tian, C.4 aut |
700 | 1 | a Tung, J. Y.4 aut |
700 | 1 | a Tunney, R. J.4 aut |
700 | 1 | a Vacic, V.4 aut |
700 | 1 | a Wang, X.4 aut |
700 | 1 | a Zare, A. S.4 aut |
700 | 1 | a Voda, A. I.4 aut |
700 | 1 | a Kashyap, P.4 aut |
700 | 1 | a Chang, L.4 aut |
700 | 1 | a Mayer, E.4 aut |
700 | 1 | a Heitkemper, M.4 aut |
700 | 1 | a Sayuk, G. S.4 aut |
700 | 1 | a Ringel-Kulka, T.4 aut |
700 | 1 | a Ringel, Y.4 aut |
700 | 1 | a Chey, W. D.4 aut |
700 | 1 | a Eswaran, S.4 aut |
700 | 1 | a Merchant, J. L.4 aut |
700 | 1 | a Shulman, R. J.4 aut |
700 | 1 | a Bujanda, L.4 aut |
700 | 1 | a Garcia-Etxebarria, K.4 aut |
700 | 1 | a Dlugosz, A.u Karolinska Institutet,Basque Foundation for Science,Biodonostia Health Research Institute,Monash University4 aut |
700 | 1 | a Lindberg, G.4 aut |
700 | 1 | a Schmidt, P. T.4 aut |
700 | 1 | a Karling, P.4 aut |
700 | 1 | a Ohlsson, Bodilu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)kir-boh |
700 | 1 | a Walter, S.4 aut |
700 | 1 | a Faresjö, Å O.4 aut |
700 | 1 | a Simrén, Magnus,d 1966u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xsimrm |
700 | 1 | a Halfvarson, J.4 aut |
700 | 1 | a Portincasa, P.4 aut |
700 | 1 | a Barbara, G.4 aut |
700 | 1 | a Usai-Satta, P.4 aut |
700 | 1 | a Neri, M.4 aut |
700 | 1 | a Nardone, G.4 aut |
700 | 1 | a Cuomo, R.4 aut |
700 | 1 | a Galeazzi, F.4 aut |
700 | 1 | a Bellini, M.4 aut |
700 | 1 | a Latiano, A.4 aut |
700 | 1 | a Houghton, L.4 aut |
700 | 1 | a Jonkers, D.4 aut |
700 | 1 | a Kurilshikov, A.4 aut |
700 | 1 | a Weersma, R. K.4 aut |
700 | 1 | a Netea, M.4 aut |
700 | 1 | a Tesarz, J.4 aut |
700 | 1 | a Gauss, A.4 aut |
700 | 1 | a Goebel-Stengel, M.4 aut |
700 | 1 | a Andresen, V.4 aut |
700 | 1 | a Frieling, T.4 aut |
700 | 1 | a Pehl, C.4 aut |
700 | 1 | a Schaefert, R.4 aut |
700 | 1 | a Niesler, B.4 aut |
700 | 1 | a Lieb, W.4 aut |
700 | 1 | a Hanevik, K.4 aut |
700 | 1 | a Langeland, N.4 aut |
700 | 1 | a Wensaas, K. A.4 aut |
700 | 1 | a Litleskare, S.4 aut |
700 | 1 | a Gabrielsen, M. E.4 aut |
700 | 1 | a Thomas, L.4 aut |
700 | 1 | a Thijs, V.4 aut |
700 | 1 | a Lemmens, R.4 aut |
700 | 1 | a Van Oudenhove, L.4 aut |
700 | 1 | a Wouters, M.4 aut |
700 | 1 | a Farrugia, G.4 aut |
700 | 1 | a Franke, A.4 aut |
700 | 1 | a Hübenthal, M.4 aut |
700 | 1 | a Abecasis, G.4 aut |
700 | 1 | a Zawistowski, M.4 aut |
700 | 1 | a Skogholt, A. H.4 aut |
700 | 1 | a Ness-Jensen, E.u Karolinska Institutet4 aut |
700 | 1 | a Hveem, K.4 aut |
700 | 1 | a Esko, T.4 aut |
700 | 1 | a Teder-Laving, M.4 aut |
700 | 1 | a Zhernakova, A.4 aut |
700 | 1 | a Camilleri, M.4 aut |
700 | 1 | a Boeckxstaens, G.4 aut |
700 | 1 | a Whorwell, P. J.4 aut |
700 | 1 | a Spiller, R.4 aut |
700 | 1 | a McVean, G.4 aut |
700 | 1 | a D’Amato, M.4 aut |
700 | 1 | a Jostins, L.4 aut |
700 | 1 | a Parkes, M.4 aut |
710 | 2 | a Karolinska Institutetb University of Oxford4 org |
710 | 2 | a et al. |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 53:11, s. 1543-1552q 53:11<1543-1552x 1061-4036x 1546-1718 |
856 | 4 | u https://www.nature.com/articles/s41588-021-00950-8.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41588-021-00950-8x freey FULLTEXT |
856 | 4 8 | u https://gup.ub.gu.se/publication/315468 |
856 | 4 8 | u https://doi.org/10.1038/s41588-021-00950-8 |
856 | 4 8 | u https://lup.lub.lu.se/record/eaed7d99-033e-4549-9b96-66d4ef218fbe |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148200898 |
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