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Repeat procedures f...
Repeat procedures for recurrent colorectal liver metastases : Analysis of long-term liver regeneration and outcome
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- Valdimarsson, Valentinus T. (author)
- Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Hellberg, Katarina (author)
- Karolinska University Hospital
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- Brismar, Torkel B. (author)
- Karolinska Institutet,Karolinska University Hospital
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- Sparrelid, Ernesto (author)
- Karolinska Institutet,Karolinska University Hospital
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- Sturesson, Christian (author)
- Karolinska Institutet,Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Karolinska University Hospital
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(creator_code:org_t)
- 2019
- 2019
- English 6 s.
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In: Cancer Management and Research. - 1179-1322. ; 11, s. 2617-2622
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Abstract
Subject headings
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- Background and aim: Repeat hepatectomy is increasingly performed for the management of recurrent colorectal liver metastases (CRLM). The aim of this study was to evaluate longterm functional liver volume (FLV) after a second hepatic procedure and to measure survival outcome. Methods: In this retrospective cohort study, patients treated for recurrent CRLM in the years 2005-2015 at two liver centers were included. Total FLV was calculated before the first procedure and before and after the second procedure. Overall survival was calculated. Results: Eighty-two patients were identified. The median follow-up was 53 (40-71) months from the first procedure. The median interval between first and second procedure was 13 (8-22) months. The initial FLV was 1584 (1313-1927) mL. The FLV was 1438 (1204-1896) mL after the first procedure and 1470 (1172-1699) mL after the second procedure (P<0.001). After the second procedure, a total of ten patients (12%) had a residual liver volume of less than 75% of the initial liver volume. The 5-year overall survival was 37 (26-54)% after the second procedure. Conclusion: Small changes in FLV were found after two hepatic procedures but with considerable inter-individual variation. Patients selected for a repeated hepatic procedure for recurrent CRLM had an acceptable survival.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Keyword
- Colorectal cancer
- Liver metastases
- Liver regeneration
- Postoperative outcomes
- Repeat hepatectomy
Publication and Content Type
- art (subject category)
- ref (subject category)
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