Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide

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Fältnamn	Indikatorer	Metadata
000		02885naa a2200361 4500
001		oai:DiVA.org:su-26799
003		SwePub
008		090414s2009 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-267992 URI
024	7	a https://doi.org/10.1007/s10552-008-9241-72 DOI
040		a (SwePub)su
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Wilson, Kathryn M.4 aut
245	1 0	a Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide
264		c 2008-10-15
264	1	b Springer Science and Business Media LLC,c 2009
338		a print2 rdacarrier
520		a OBJECTIVE: Acrylamide, a probable human carcinogen, is formed during high-heat cooking of many common foods. The validity of food frequency questionnaire (FFQ) measures of acrylamide intake has not been established. We assessed the validity of acrylamide intake calculated from an FFQ using a biomarker of acrylamide exposure. METHODS: We calculated acrylamide intake from an FFQ in the Nurses' Health Study II. We measured hemoglobin adducts of acrylamide and its metabolite, glycidamide, in a random sample of 342 women. Correlation and regression analyses were used to assess the relationship between acrylamide intakes and adducts. RESULTS: The correlation between acrylamide intake and the sum of acrylamide and glycidamide adducts was 0.31 (95% CI: 0.20-0.41), adjusted for laboratory batch, energy intake, and age. Further adjustment for BMI, alcohol intake, and correction for random within-person measurement error in adducts gave a correlation of 0.34 (CI: 0.23-0.45). The intraclass correlation coefficient for the sum of adducts was 0.77 in blood samples collected 1-3 years apart in a subset of 45 women. Intake of several foods significantly predicted adducts in multiple regression. CONCLUSIONS: Acrylamide intake and hemoglobin adducts of acrylamide and glycidamide were moderately correlated. Within-person consistency in adducts was high over time.
700	1	a Vesper, Hubert W.4 aut
700	1	a Tocco, Paula4 aut
700	1	a Sampson, Laura4 aut
700	1	a Rosén, Johan4 aut
700	1	a Hellenäs, Karl-Erik4 aut
700	1	a Törnqvist, Margaretau Stockholms universitet,Institutionen för miljökemi4 aut0 (Swepub:su)mt
700	1	a Willett, Walter C.4 aut
710	2	a Stockholms universitetb Institutionen för miljökemi4 org
773	0	t Cancer Causes and Controld : Springer Science and Business Media LLCg 20:3, s. 269-278q 20:3<269-278x 0957-5243x 1573-7225
856	4	u https://europepmc.org/articles/pmc3147248?pdf=render
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-26799
856	4 8	u https://doi.org/10.1007/s10552-008-9241-7

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