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  • Omenn, Gilbert S.Univ Michigan, Ann Arbor, MI 48109 USA.;Inst Syst Biol, Seattle, WA 98109 USA. (författare)

The 2023 Report on the Proteome from the HUPO Human Proteome Project

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • American Chemical Society (ACS),2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-523979
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523979URI
  • https://doi.org/10.1021/acs.jproteome.3c00591DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:for swepub-publicationtype

Anmärkningar

  • Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2) to make proteomics an integral part of multiomics studies of human health and disease. The HPP relies on international collaboration, data sharing, standardized reanalysis of MS data sets by PeptideAtlas and MassIVE-KB using HPP Guidelines for quality assurance, integration and curation of MS and non-MS protein data by neXtProt, plus extensive use of antibody profiling carried out by the Human Protein Atlas. According to the neXtProt release 2023-04-18, protein expression has now been credibly detected (PE1) for 18,397 of the 19,778 neXtProt predicted proteins coded in the human genome (93%). Of these PE1 proteins, 17,453 were detected with mass spectrometry (MS) in accordance with HPP Guidelines and 944 by a variety of non-MS methods. The number of neXtProt PE2, PE3, and PE4 missing proteins now stands at 1381. Achieving the unambiguous identification of 93% of predicted proteins encoded from across all chromosomes represents remarkable experimental progress on the Human Proteome parts list. Meanwhile, there are several categories of predicted proteins that have proved resistant to detection regardless of protein-based methods used. Additionally there are some PE1–4 proteins that probably should be reclassified to PE5, specifically 21 LINC entries and ∼30 HERV entries; these are being addressed in the present year. Applying proteomics in a wide array of biological and clinical studies ensures integration with other omics platforms as reported by the Biology and Disease-driven HPP teams and the antibody and pathology resource pillars. Current progress has positioned the HPP to transition to its Grand Challenge Project focused on determining the primary function(s) of every protein itself and in networks and pathways within the context of human health and disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lane, LydieSIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland.;Univ Geneva, CH-1015 Lausanne, Switzerland. (författare)
  • Overall, Christopher M.Univ British Columbia, Vancouver, BC V6T 1Z4, Canada.;Yonsei Univ, Seoul 03722, South Korea. (författare)
  • Lindskog, CeciliaUppsala universitet,Cancerprecisionsmedicin(Swepub:uu)cecli129 (författare)
  • Pineau, CharlesUniv Rennes, F-35042 Rennes, France. (författare)
  • Packer, Nicolle H.Macquarie Univ, Sydney, NSW 2109, Australia. (författare)
  • Cristea, Ileana M.Princeton Univ, Princeton, NJ 08544 USA. (författare)
  • Weintraub, Susan T.Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA. (författare)
  • Orchard, SandraEMBL EBI, Hinxton CB10 1SD, Cambs, England. (författare)
  • Roehrl, Michael H. A.Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA. (författare)
  • Nice, EdouardMonash Univ, Clayton, Vic 3800, Australia. (författare)
  • Guo, TiannanWestlake Univ, Westlake Ctr Intelligent Prote, Westlake Lab, Hangzhou 310024, Zhejiang, Peoples R China. (författare)
  • Van Eyk, Jennifer E.Cedars Sinai Med Ctr, Adv Clin Biosyst Res Inst, Smidt Heart Inst, Los Angeles, CA 90048 USA. (författare)
  • Liu, SiqiBGI China, Shenzhen 518083, Peoples R China. (författare)
  • Bandeira, NunoUniv Calif, La Jolla, CA 92093 USA. (författare)
  • Aebersold, RuediSwiss Fed Inst Technol, Swiss Fed Inst Technol Zurich, Inst Mol Syst Biol, CH-8092 Zurich, Switzerland.;Univ Zurich, CH-8092 Zurich, Switzerland. (författare)
  • Moritz, Robert L.Inst Syst Biol, Seattle, WA 98109 USA. (författare)
  • Deutsch, Eric W.Inst Syst Biol, Seattle, WA 98109 USA. (författare)
  • Univ Michigan, Ann Arbor, MI 48109 USA.;Inst Syst Biol, Seattle, WA 98109 USA.SIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland.;Univ Geneva, CH-1015 Lausanne, Switzerland. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Proteome Research: American Chemical Society (ACS)23:2, s. 532-5491535-38931535-3907

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