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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006025naa a2200649 4500
001oai:DiVA.org:uu-523979
003SwePub
008240227s2024 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5239792 URI
0247 a https://doi.org/10.1021/acs.jproteome.3c005912 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Omenn, Gilbert S.u Univ Michigan, Ann Arbor, MI 48109 USA.;Inst Syst Biol, Seattle, WA 98109 USA.4 aut
2451 0a The 2023 Report on the Proteome from the HUPO Human Proteome Project
264 1b American Chemical Society (ACS),c 2024
338 a print2 rdacarrier
520 a Since 2010, the Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify the protein parts list and (2) to make proteomics an integral part of multiomics studies of human health and disease. The HPP relies on international collaboration, data sharing, standardized reanalysis of MS data sets by PeptideAtlas and MassIVE-KB using HPP Guidelines for quality assurance, integration and curation of MS and non-MS protein data by neXtProt, plus extensive use of antibody profiling carried out by the Human Protein Atlas. According to the neXtProt release 2023-04-18, protein expression has now been credibly detected (PE1) for 18,397 of the 19,778 neXtProt predicted proteins coded in the human genome (93%). Of these PE1 proteins, 17,453 were detected with mass spectrometry (MS) in accordance with HPP Guidelines and 944 by a variety of non-MS methods. The number of neXtProt PE2, PE3, and PE4 missing proteins now stands at 1381. Achieving the unambiguous identification of 93% of predicted proteins encoded from across all chromosomes represents remarkable experimental progress on the Human Proteome parts list. Meanwhile, there are several categories of predicted proteins that have proved resistant to detection regardless of protein-based methods used. Additionally there are some PE1–4 proteins that probably should be reclassified to PE5, specifically 21 LINC entries and ∼30 HERV entries; these are being addressed in the present year. Applying proteomics in a wide array of biological and clinical studies ensures integration with other omics platforms as reported by the Biology and Disease-driven HPP teams and the antibody and pathology resource pillars. Current progress has positioned the HPP to transition to its Grand Challenge Project focused on determining the primary function(s) of every protein itself and in networks and pathways within the context of human health and disease.
650 7a NATURVETENSKAPx Biologix Biokemi och molekylärbiologi0 (SwePub)106022 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Biochemistry and Molecular Biology0 (SwePub)106022 hsv//eng
650 7a NATURVETENSKAPx Biologix Bioinformatik och systembiologi0 (SwePub)106102 hsv//swe
650 7a NATURAL SCIENCESx Biological Sciencesx Bioinformatics and Systems Biology0 (SwePub)106102 hsv//eng
653 a Human Proteome Organization (HUPO)
653 a Human Proteome Project (HPP)
653 a neXtProt protein existence (PE) metrics
653 a missing proteins (MP)
653 a non-MS PE1 proteins
653 a uncharacterizedprotein existence 1 (uPE1)
653 a Chromosome-centric HPP (C-HPP)
653 a Biology and Disease-HPP (B/D-HPP)
653 a PeptideAtlas
653 a Mass Spectrometry Interactive Virtual Environment Knowledge Base (MassIVE-KB)
653 a Human Protein Atlas
653 a Grand Challenge Project
7001 a Lane, Lydieu SIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland.;Univ Geneva, CH-1015 Lausanne, Switzerland.4 aut
7001 a Overall, Christopher M.u Univ British Columbia, Vancouver, BC V6T 1Z4, Canada.;Yonsei Univ, Seoul 03722, South Korea.4 aut
7001 a Lindskog, Ceciliau Uppsala universitet,Cancerprecisionsmedicin4 aut0 (Swepub:uu)cecli129
7001 a Pineau, Charlesu Univ Rennes, F-35042 Rennes, France.4 aut
7001 a Packer, Nicolle H.u Macquarie Univ, Sydney, NSW 2109, Australia.4 aut
7001 a Cristea, Ileana M.u Princeton Univ, Princeton, NJ 08544 USA.4 aut
7001 a Weintraub, Susan T.u Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA.4 aut
7001 a Orchard, Sandrau EMBL EBI, Hinxton CB10 1SD, Cambs, England.4 aut
7001 a Roehrl, Michael H. A.u Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02215 USA.4 aut
7001 a Nice, Edouardu Monash Univ, Clayton, Vic 3800, Australia.4 aut
7001 a Guo, Tiannanu Westlake Univ, Westlake Ctr Intelligent Prote, Westlake Lab, Hangzhou 310024, Zhejiang, Peoples R China.4 aut
7001 a Van Eyk, Jennifer E.u Cedars Sinai Med Ctr, Adv Clin Biosyst Res Inst, Smidt Heart Inst, Los Angeles, CA 90048 USA.4 aut
7001 a Liu, Siqiu BGI China, Shenzhen 518083, Peoples R China.4 aut
7001 a Bandeira, Nunou Univ Calif, La Jolla, CA 92093 USA.4 aut
7001 a Aebersold, Ruediu Swiss Fed Inst Technol, Swiss Fed Inst Technol Zurich, Inst Mol Syst Biol, CH-8092 Zurich, Switzerland.;Univ Zurich, CH-8092 Zurich, Switzerland.4 aut
7001 a Moritz, Robert L.u Inst Syst Biol, Seattle, WA 98109 USA.4 aut
7001 a Deutsch, Eric W.u Inst Syst Biol, Seattle, WA 98109 USA.4 aut
7102 a Univ Michigan, Ann Arbor, MI 48109 USA.;Inst Syst Biol, Seattle, WA 98109 USA.b SIB Swiss Inst Bioinformat, CALIPHO Grp, CH-1015 Lausanne, Switzerland.;Univ Geneva, CH-1015 Lausanne, Switzerland.4 org
7730 t Journal of Proteome Researchd : American Chemical Society (ACS)g 23:2, s. 532-549q 23:2<532-549x 1535-3893x 1535-3907
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-523979
8564 8u https://doi.org/10.1021/acs.jproteome.3c00591

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