Sökning: WFRF:(Wiklund Christer)
> (2020-2023) >
High use of short-a...
High use of short-acting beta(2)-agonists in COPD is associated with an increased risk of exacerbations and mortality
-
- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
-
- Wiklund, Fredrik (författare)
- Statisticon AB, Uppsala, Sweden.
-
- Telg, Gunilla (författare)
- AstraZeneca Nord, Stockholm, Sweden.
-
visa fler...
-
- Stratelis, Georgios (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,AstraZeneca Nord, Stockholm, Sweden.
-
- Sandelowsky, Hanna (författare)
- Karolinska Inst, Dept Med Solna, Div Clin Epidemiol, Stockholm, Sweden.;Karolinska Inst, Div Family Med & Primary Care, Dept Neurobiol, Care Sci & Soc, Stockholm, Sweden.;Acad Primary Hlth Care Ctr, Stockholm, Sweden.
-
visa färre...
-
(creator_code:org_t)
- European Respiratory Society, 2023
- 2023
- Engelska.
-
Ingår i: ERJ Open Research. - : European Respiratory Society. - 2312-0541. ; 9:3
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Background: Short-acting beta(2)-agonist (SABA) overuse has been associated with an increased risk of exacerbations in asthma; however, less is known about SABA use in COPD. Our aim was to describe SABA use and investigate potential associations between high SABA use and the risk of future exacerbations and mortality in COPD.Methods: This observational study identified COPD patients in primary care medical records in Sweden. Data were linked to the National Patient Registry, the Prescribed Drug Registry and the Cause of Death Registry. The index date was 12 months after the date of COPD diagnosis. During a 12-month prior to index baseline period, information on SABA use was collected. Patients were followed with respect to exacerbations and mortality for 12 months post index.Results: Of the 19 794 COPD patients included (mean age 69.1 years, 53.3% females), 15.5% and 7.0% had collected >= 3 or >= 6 SABA canisters during the baseline period, respectively. A higher level of SABA use (>= 6 canisters) was independently associated with a higher risk of both moderate and severe exacerbations (hazard ratio (HR) 1.28 (95% CI 1.17.1.40) and 1.76 (95% CI 1.50.2.06), respectively) during follow-up. In total, 673 (3.4%) patients died during the 12-month follow-up period. An independent association was found between high SABA use and overall mortality (HR 1.60, 95% CI 1.07.2.39). This association, however, was not found in patients using inhaled corticosteroids as maintenance treatment.Conclusion: In COPD patients in Sweden, high SABA use is relatively common and associated with a higher risk of exacerbations and all-cause mortality.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas