Sökning: WFRF:(Yves A) > (2010-2014) > Allotransplantation...
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000 | 05454naa a2200949 4500 | |
001 | oai:DiVA.org:uu-228962 | |
003 | SwePub | |
008 | 140724s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129246220 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2289622 URI |
024 | 7 | a https://doi.org/10.1016/j.bbmt.2014.03.0132 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1292462202 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a McClune, Brian L.4 aut |
245 | 1 0 | a Allotransplantation for Patients Age >= 40 Years with Non-Hodgkin Lymphoma :b Encouraging Progression-Free Survival |
264 | 1 | b Elsevier BV,c 2014 |
338 | a print2 rdacarrier | |
520 | a Non-Hodgkin lymphoma (NHL) disproportionately affects older patients, who do not often undergo allogeneic hematopoietic cell transplantation (HCT). We analyzed Center for International Blood and Marrow Transplant Research data on 1248 patients age >= 40 years receiving reduced-intensity conditioning (RIC) or nonmyeloablative (NMA) conditioning HCT for aggressive (n = 668) or indolent (n = 580) NHL Aggressive lymphoma was more frequent in the oldest cohort 49% for age 40 to 54 versus 57% for age 55 to 64 versus 67% for age >= 65; P = .0008). Fewer patients aged >= 65 had previous autografting (26% versus 24% versus 9%; P = .002). Rates of relapse, acute and chronic GVHD, and nonrelapse mortality (NRM) at 1 year post-HCT were similar in the 3 age cohorts (22% [95% confidence interval (CI), 19% to 26%] for age 40 to 54, 27% [95% CI, 23% to 31%] for age 55 to 64, and 34% [95% CI, 24% to 44%] for age >= 65. Progression-free survival (PFS) and overall survival (OS) at 3 years was slightly lower in the older cohorts (OS: 54% [95% CI, 50% to 58%] for age 40 to 54; 40% [95% CI, 36% to 44%] for age 55 to 64, and 39% [95% CI, 28% to 50%] for age >= 65; P < .0001). Multivariate analysis revealed no significant effect of age on the incidence of acute or chronic GVHD or relapse. Age >= 55 years, Karnofsky Performance Status <80, and HLA mismatch adversely affected NRM, PFS, and OS. Disease status at HCT, but not histological subtype, was associated with worse NRM, relapse, PFS, and OS. Even for patients age >= 55 years, OS still approached 40% at 3 years, suggesting that HCT affects long-term remission and remains underused in qualified older patients with NHL. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
653 | a Reduced intensity | |
653 | a Nonmyeloablative | |
653 | a Allogeneic | |
653 | a Hematopoietic cell transplantation | |
653 | a Elderly | |
653 | a Lymphoma | |
700 | 1 | a Ahn, Kwang Woo4 aut |
700 | 1 | a Wang, Hai-Lin4 aut |
700 | 1 | a Antin, Joseph H.4 aut |
700 | 1 | a Artz, Andrew S.4 aut |
700 | 1 | a Cahn, Jean-Yves4 aut |
700 | 1 | a Deol, Abhinav4 aut |
700 | 1 | a Freytes, Cesar O.4 aut |
700 | 1 | a Hamadani, Mehdi4 aut |
700 | 1 | a Holmberg, Leona A.4 aut |
700 | 1 | a Jagasia, Madan H.4 aut |
700 | 1 | a Jakubowski, Ann A.4 aut |
700 | 1 | a Kharfan-Dabaja, Mohamed A.4 aut |
700 | 1 | a Lazarus, Hillard M.4 aut |
700 | 1 | a Miller, Alan M.4 aut |
700 | 1 | a Olsson, Richardu Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD)4 aut0 (Swepub:uu)riols677 |
700 | 1 | a Pedersen, Tanya L.4 aut |
700 | 1 | a Pidala, Joseph4 aut |
700 | 1 | a Pulsipher, Michael A.4 aut |
700 | 1 | a Rowe, Jacob M.4 aut |
700 | 1 | a Saber, Wael4 aut |
700 | 1 | a van Besien, Koen W.4 aut |
700 | 1 | a Waller, Edmund K.4 aut |
700 | 1 | a Aljurf, Mahmoud D.4 aut |
700 | 1 | a Akpek, Goergun4 aut |
700 | 1 | a Bacher, Ulrike4 aut |
700 | 1 | a Chao, Nelson J.4 aut |
700 | 1 | a Chen, Yi-Bin4 aut |
700 | 1 | a Cooper, Brenda W.4 aut |
700 | 1 | a Dehn, Jason4 aut |
700 | 1 | a de Lima, Marcos J.4 aut |
700 | 1 | a Hsu, Jack W.4 aut |
700 | 1 | a Lewis, Ian D.4 aut |
700 | 1 | a Marks, David I.4 aut |
700 | 1 | a McGuirk, Joseph4 aut |
700 | 1 | a Cairo, Mitchell S.4 aut |
700 | 1 | a Schouten, Harry C.4 aut |
700 | 1 | a Szer, Jeffrey4 aut |
700 | 1 | a Ramanathan, Muthalagu4 aut |
700 | 1 | a Savani, Bipin N.4 aut |
700 | 1 | a Seftel, Matthew4 aut |
700 | 1 | a Socie, Gerard4 aut |
700 | 1 | a Vij, Ravi4 aut |
700 | 1 | a Warlick, Erica D.4 aut |
700 | 1 | a Weisdorf, Daniel J.4 aut |
710 | 2 | a Uppsala universitetb Centrum för klinisk forskning i Sörmland (CKFD)4 org |
773 | 0 | t Biology of blood and marrow transplantationd : Elsevier BVg 20:7, s. 960-968q 20:7<960-968x 1083-8791x 1523-6536 |
856 | 4 | u http://www.bbmt.org/article/S1083879114001621/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228962 |
856 | 4 8 | u https://doi.org/10.1016/j.bbmt.2014.03.013 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129246220 |
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