Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region

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Fältnamn	Indikatorer	Metadata
000		06786naa a2201237 4500
001		oai:DiVA.org:umu-161986
003		SwePub
008		190814s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:aaa367fc-fa2c-487c-b5d1-d55a6d065ccd
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1619862 URI
024	7	a https://doi.org/10.1016/j.jtho.2019.04.0082 DOI
024	7	a https://lup.lub.lu.se/record/aaa367fc-fa2c-487c-b5d1-d55a6d065ccd2 URI
040		a (SwePub)umud (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Hung, Rayjean J.u Sinai Health System4 aut
245	1 0	a Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5(p)15.33 TERT-CLPTM1Ll Region
264	1	b ELSEVIER SCIENCE INC,c 2019
338		a electronic2 rdacarrier
520		a Introduction: Inherited susceptibility to lung cancer risk in never-smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study on the largest, to date, set of European-descent never-smokers with lung cancer. Methods: We conducted a two-phase (discovery and replication) genome-wide association study in never-smokers of European descent. We further augmented the sample by performing a meta-analysis with never-smokers from the recent OncoArray study, which resulted in a total of 3636 cases and 6295 controls. We also compare our findings with those in smokers with lung cancer. Results: We detected three genome-wide statistically significant single nucleotide polymorphisms rs31490 (odds ratio [OR]: 0.769, 95% confidence interval [CI]: 0.722-0.820; p value 5.31 x 10(-16)), rs380286 (OR: 0.770, 95% CI: 0.723-0.820; p value 4.32 x 10(-16)), and rs4975616 OR: 0.778, 95% CI: 0.730-0.829; p value 1.04 x 10(-14)). All three mapped to Chromosome 5 CLPTM1L-TERT region, previously shown to be associated with lung cancer risk in smokers and in never-smoker Asian women, and risk of other cancers including breast, ovarian, colorectal, and prostate. Conclusions: We found that genetic susceptibility to lung cancer in never-smokers is associated to genetic variants with pan-cancer risk effects. The comparison with smokers shows that top variants previously shown to be associated with lung cancer risk only confer risk in the presence of tobacco exposure, underscoring the importance of gene-environment interactions in the etiology of this disease. (C) 2019 International Association for the Study of Lung Cancer. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653		a Lung cancer
653		a Never smokers
653		a Genome-wide association study
653		a Genetic susceptibility
653		a Genetic susceptibility
653		a Genome-wide association study
653		a Lung cancer
653		a Never smokers
700	1	a Spitz, Margaret R.4 aut
700	1	a Houlston, Richard S.4 aut
700	1	a Schwartz, Ann G.4 aut
700	1	a Field, John K.4 aut
700	1	a Ying, Jun4 aut
700	1	a Li, Yafang4 aut
700	1	a Han, Younghun4 aut
700	1	a Ji, Xuemei4 aut
700	1	a Chen, Wei4 aut
700	1	a Wu, Xifeng4 aut
700	1	a Gorlov, Ivan P.4 aut
700	1	a Na, Jie4 aut
700	1	a de Andrade, Mariza4 aut
700	1	a Liu, Geoffrey4 aut
700	1	a Brhane, Yonathan4 aut
700	1	a Diao, Nancy4 aut
700	1	a Wenzlaff, Angela4 aut
700	1	a Davies, Michael P. A.4 aut
700	1	a Liloglou, Triantafillos4 aut
700	1	a Timofeeva, Maria4 aut
700	1	a Muley, Thomas4 aut
700	1	a Rennert, Hedy4 aut
700	1	a Saliba, Walid4 aut
700	1	a Ryan, Brid M.4 aut
700	1	a Bowman, Elise4 aut
700	1	a Barros-Dios, Juan-Miguel4 aut
700	1	a Perez-Rios, Monica4 aut
700	1	a Morgenstern, Hal4 aut
700	1	a Zienolddiny, Shanbeh4 aut
700	1	a Skaug, Vidar4 aut
700	1	a Ugolini, Donatella4 aut
700	1	a Bonassi, Stefano4 aut
700	1	a van der Heijden, Erik H. F. M.4 aut
700	1	a Tardon, Adonina4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Landi, Maria Teresa4 aut
700	1	a Johansson, Mattias4 aut
700	1	a Bickeboeller, Heike4 aut
700	1	a Arnold, Susanne4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Andrew, Angeline4 aut
700	1	a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002
700	1	a Caporaso, Neil4 aut
700	1	a Teare, M. Dawn4 aut
700	1	a Schabath, Matthew B.4 aut
700	1	a Aldrich, Melinda C.4 aut
700	1	a Kiemeney, Lambertus A.4 aut
700	1	a Wichmann, H-Erich4 aut
700	1	a Lazarus, Philip4 aut
700	1	a Mayordomo, Jose4 aut
700	1	a Neri, Monica4 aut
700	1	a Haugen, Aage4 aut
700	1	a Zhang, Zuo-Feng4 aut
700	1	a Ruano-Ravina, Alberto4 aut
700	1	a Brenner, Hermann4 aut
700	1	a Harris, Curtis C.4 aut
700	1	a Orlow, Irene4 aut
700	1	a Rennert, Gadi4 aut
700	1	a Risch, Angela4 aut
700	1	a Brennan, Paul4 aut
700	1	a Christiani, David C.4 aut
700	1	a Amos, Christopher I.4 aut
700	1	a Yang, Ping4 aut
700	1	a Gorlova, Olga Y.u Dartmouth College4 aut
710	2	a Sinai Health Systemb Kardiovaskulär forskning - hypertoni4 org
710	2	a et al.
773	0	t Journal of Thoracic Oncologyd : ELSEVIER SCIENCE INCg 14:8, s. 1360-1369q 14:8<1360-1369x 1556-0864x 1556-1380
856	4	u https://umu.diva-portal.org/smash/get/diva2:1342593/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u http://www.jto.org/article/S1556086419302898/pdf
856	4	u http://dx.doi.org/10.1016/j.jtho.2019.04.008x freey FULLTEXT
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-161986
856	4 8	u https://doi.org/10.1016/j.jtho.2019.04.008
856	4 8	u https://lup.lub.lu.se/record/aaa367fc-fa2c-487c-b5d1-d55a6d065ccd

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Av författaren/redakt...: Hung, Rayjean J.; Spitz, Margaret ...; Houlston, Richar ...; Schwartz, Ann G.; Field, John K.; Ying, Jun; visa fler...; Li, Yafang; Han, Younghun; Ji, Xuemei; Chen, Wei; Wu, Xifeng; Gorlov, Ivan P.; Na, Jie; de Andrade, Mari ...; Liu, Geoffrey; Brhane, Yonathan; Diao, Nancy; Wenzlaff, Angela; Davies, Michael ...; Liloglou, Triant ...; Timofeeva, Maria; Muley, Thomas; Rennert, Hedy; Saliba, Walid; Ryan, Brid M.; Bowman, Elise; Barros-Dios, Jua ...; Perez-Rios, Moni ...; Morgenstern, Hal; Zienolddiny, Sha ...; Skaug, Vidar; Ugolini, Donatel ...; Bonassi, Stefano; van der Heijden, ...; Tardon, Adonina; Bojesen, Stig E.; Landi, Maria Ter ...; Johansson, Matti ...; Bickeboeller, He ...; Arnold, Susanne; Le Marchand, Loi ...; Melander, Olle; Andrew, Angeline; Grankvist, Kjell; Caporaso, Neil; Teare, M. Dawn; Schabath, Matthe ...; Aldrich, Melinda ...; Kiemeney, Lamber ...; Wichmann, H-Eric ...; Lazarus, Philip; Mayordomo, Jose; Neri, Monica; Haugen, Aage; Zhang, Zuo-Feng; Ruano-Ravina, Al ...; Brenner, Hermann; Harris, Curtis C ...; Orlow, Irene; Rennert, Gadi; Risch, Angela; Brennan, Paul; Christiani, Davi ...; Amos, Christophe ...; Yang, Ping; Gorlova, Olga Y.; visa färre...

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