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Early abciximab adm...
Early abciximab administration before transfer for primary percutaneous coronary interventions for ST-elevation myocardial infarction reduces 1-year mortality in patients with high-risk profile. Results from EUROTRANSFER Registry
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- Rakowski, Tomasz (author)
- Jagiellonian University
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- Siudak, Zbigniew (author)
- Jagiellonian University
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- Dziewierz, Artur (author)
- Jagiellonian University
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- Birkemeyer, Ralf (author)
- Schwarzwald Baar Klinikum Villingen Schwenningen
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- Legutko, Jacek (author)
- Jagiellonian University
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- Mielecki, Waldemar (author)
- Jagiellonian University
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- Depukat, Rafal (author)
- Jagiellonian University
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- Janzon, Magnus (author)
- Östergötlands Läns Landsting,Linköpings universitet,Kardiologi,Hälsouniversitetet,Kardiologiska kliniken
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- Stefaniak, Justyna (author)
- Krakow Cardiovasc Research Institute
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- Zmudka, Krzysztof (author)
- Jagiellonian University
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- Dubiel, Jacek S (author)
- Jagiellonian University
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- Partyka, Lukasz (author)
- Krakow Cardiovasc Research Institute
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- Dudek, Dariusz (author)
- Jagiellonian University
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(creator_code:org_t)
- Elsevier BV, 2009
- 2009
- English.
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In: AMERICAN HEART JOURNAL. - : Elsevier BV. - 0002-8703. ; 158:4, s. 569-575
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background There are conflicting data on the clinical benefit from early administration of abciximab from a large randomized trial and a registry. However, both sources suggest that a benefit may depend on the baseline risk profile of the patients. We evaluated the role of early abciximab administration in patients with ST-segment-elevation myocardial infarction (STEMI) referred for primary percutaneous coronary intervention stratified by the STEMI Thrombolysis In Myocardial Infarction (TIMI) risk score. Methods A total of 1,650 patients were enrolled into the EUROTRANSFER Registry. One thousand eighty-six patients received abciximab (66%). Abciximab was administered early in 727 patients (EA) and late in 359 patients (LA). We used the TIMI risk score for risk stratification. Patients with scores 3 constituted the high-risk group of 616 patients (56.7%), whereas 470 patients formed the low-risk cohort. Factoring in the timing of the abciximab administration resulted in 4 groups of patients who were compared for mortality at 1 year: EA/high-risk (n = 413); LA/high-risk (n = 203); EA/low-risk (n = 3 14); LA/low-risk (n = 156). Baseline difference was accounted for by means of propensity score. Results In high-risk patients, 1-year mortality was significantly lower with early abcximab compared to late administration (8.7% vs 15.8%; odds ratio 0.51, CI 0.31-0.85, P = .01). In multivariable Cox regression analysis, both early abciximab administration and patients risk profile (TIMI score :3) were identified as independent predictors of 1-year mortality. Conclusions Early abciximab administration before transfer for percutaneous coronary intervention in STEMI shows lower mortality at 1-year follow-up. This effect is confined to patients with higher risk profile as defined by TIMI risk score andgt;= 3.
Keyword
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Rakowski, Tomasz
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Siudak, Zbigniew
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Dziewierz, Artur
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Birkemeyer, Ralf
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Legutko, Jacek
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Mielecki, Waldem ...
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show more...
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Depukat, Rafal
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Janzon, Magnus
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Stefaniak, Justy ...
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Zmudka, Krzyszto ...
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Dubiel, Jacek S
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Partyka, Lukasz
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Dudek, Dariusz
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show less...
- Articles in the publication
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AMERICAN HEART J ...
- By the university
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Linköping University