Sökning: WFRF:(Zweegman Sonja) > Distinct clustering...
Fältnamn | Indikatorer | Metadata |
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000 | 03928naa a2200613 4500 | |
001 | oai:DiVA.org:uu-235521 | |
003 | SwePub | |
008 | 141105s2014 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:129790070 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2355212 URI |
024 | 7 | a https://doi.org/10.1182/blood-2013-09-5279032 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1297900702 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Geyer, Holly L.4 aut |
245 | 1 0 | a Distinct clustering of symptomatic burden among myeloproliferative neoplasm patients :b retrospective assessment in 1470 patients |
264 | 1 | b American Society of Hematology,c 2014 |
338 | a print2 rdacarrier | |
520 | a Symptom burden in myeloproliferative neoplasms (MPNs) is heterogeneous even among patients within the same MPN diagnosis. Using cluster analysis from prospectively gathered symptom burden data in 1470 international patients with essential thrombocythemia (ET), polycythemia vera (PV), or myelofibrosis (MF), we assessed for the presence of clusters and relationship to disease features and prognosis. In MF (4 clusters identified), clusters significantly differed by Dynamic International Prognostic Scoring System (DIPSS) risk (P < .001), leukopenia (P = .009), thrombocytopenia (P < .001), and spleen size (P = .02). Although an association existed between clusters and DIPSS risk, high symptom burden was noted in some low and intermediate-1-risk MF patients. In PV (5 clusters identified), total symptom score increased across clusters (P < .001), but clusters did not significantly differ by PV risk or the risk assessment variable of age. Among ET patients (5 clusters identified), clusters differed by gender (P = .04), anemia (P = .01), and prior hemorrhage (P = .047). Total symptom score increased across clusters (P < .001), but clusters did not significantly differ by International Prognostic Score for ET risk including the risk assessment variables. Significant symptom heterogeneity exists within each MPN subtype, sometimes independent of disease features or prognosis. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Hematologi0 (SwePub)302022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Hematology0 (SwePub)302022 hsv//eng |
700 | 1 | a Scherber, Robyn M.4 aut |
700 | 1 | a Dueck, Amylou C.4 aut |
700 | 1 | a Kiladjian, Jean-Jacques4 aut |
700 | 1 | a Xiao, Zhijian4 aut |
700 | 1 | a Slot, Stefanie4 aut |
700 | 1 | a Zweegman, Sonja4 aut |
700 | 1 | a Sackmann, Federico4 aut |
700 | 1 | a Kerguelen Fuentes, Ana4 aut |
700 | 1 | a Hernandez-Maraver, Dolores4 aut |
700 | 1 | a Doehner, Konstanze4 aut |
700 | 1 | a Harrison, Claire N.4 aut |
700 | 1 | a Radia, Deepti4 aut |
700 | 1 | a Muxi, Pablo4 aut |
700 | 1 | a Besses, Carlos4 aut |
700 | 1 | a Cervantes, Francisco4 aut |
700 | 1 | a Johansson, Peter L.4 aut |
700 | 1 | a Andreasson, Bjorn4 aut |
700 | 1 | a Rambaldi, Alessandro4 aut |
700 | 1 | a Barbui, Tiziano4 aut |
700 | 1 | a Vannucchi, Alessandro M.4 aut |
700 | 1 | a Passamonti, Francesco4 aut |
700 | 1 | a Samuelsson, Janu Karolinska Institutet4 aut |
700 | 1 | a Birgegård, Gunnaru Uppsala universitet,Hematologi4 aut0 (Swepub:uu)gunnarbg |
700 | 1 | a Mesa, Ruben A.4 aut |
710 | 2 | a Karolinska Institutetb Hematologi4 org |
773 | 0 | t Bloodd : American Society of Hematologyg 123:24, s. 3803-3810q 123:24<3803-3810x 0006-4971x 1528-0020 |
856 | 4 | u https://europepmc.org/articles/pmc4067502 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-235521 |
856 | 4 8 | u https://doi.org/10.1182/blood-2013-09-527903 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:129790070 |
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