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Sökning: WFRF:(van Engelen BGM) > Cytosolic 5'-nucleo...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003766naa a2200565 4500
001oai:prod.swepub.kib.ki.se:135467654
003SwePub
008240701s2017 | |||||||||||000 ||eng|
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1354676542 URI
0247 a https://doi.org/10.1136/annrheumdis-2016-2102822 DOI
040 a (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Lilleker, JB4 aut
2451 0a Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis
264 c 2017-01-25
264 1b BMJ,c 2017
520 a Autoantibodies directed against cytosolic 5′-nucleotidase 1A have been identified in many patients with inclusion body myositis. This retrospective study investigated the association between anticytosolic 5′-nucleotidase 1A antibody status and clinical, serological and histopathological features to explore the utility of this antibody to identify inclusion body myositis subgroups and to predict prognosis.Materials and methodsData from various European inclusion body myositis registries were pooled. Anticytosolic 5′-nucleotidase 1A status was determined by an established ELISA technique. Cases were stratified according to antibody status and comparisons made. Survival and mobility aid requirement analyses were performed using Kaplan-Meier curves and Cox proportional hazards regression.ResultsData from 311 patients were available for analysis; 102 (33%) had anticytosolic 5′-nucleotidase 1A antibodies. Antibody-positive patients had a higher adjusted mortality risk (HR 1.89, 95% CI 1.11 to 3.21, p=0.019), lower frequency of proximal upper limb weakness at disease onset (8% vs 23%, adjusted OR 0.29, 95% CI 0.12 to 0.68, p=0.005) and an increased prevalence of excess of cytochrome oxidase deficient fibres on muscle biopsy analysis (87% vs 72%, adjusted OR 2.80, 95% CI 1.17 to 6.66, p=0.020), compared with antibody-negative patients.InterpretationDifferences were observed in clinical and histopathological features between anticytosolic 5′-nucleotidase 1A antibody positive and negative patients with inclusion body myositis, and antibody-positive patients had a higher adjusted mortality risk. Stratification of inclusion body myositis by anticytosolic 5′-nucleotidase 1A antibody status may be useful, potentially highlighting a distinct inclusion body myositis subtype with a more severe phenotype.
7001 a Rietveld, A4 aut
7001 a Pye, SR4 aut
7001 a Mariampillai, K4 aut
7001 a Benveniste, O4 aut
7001 a Peeters, MTJ4 aut
7001 a Miller, JAL4 aut
7001 a Hanna, MG4 aut
7001 a Machado, PM4 aut
7001 a Parton, MJ4 aut
7001 a Gheorghe, KRu Karolinska Institutet4 aut
7001 a Badrising, UA4 aut
7001 a Lundberg, IEu Karolinska Institutet4 aut
7001 a Sacconi, S4 aut
7001 a Herbert, MK4 aut
7001 a McHugh, NJ4 aut
7001 a Lecky, BRF4 aut
7001 a Brierley, C4 aut
7001 a Hilton-Jones, D4 aut
7001 a Lamb, JA4 aut
7001 a Roberts, ME4 aut
7001 a Cooper, RG4 aut
7001 a Saris, CGJ4 aut
7001 a Pruijn, GJM4 aut
7001 a Chinoy, H4 aut
7001 a van Engelen, BGM4 aut
7102 a Karolinska Institutet4 org
7730 t Annals of the rheumatic diseasesd : BMJg 76:5, s. 862-868q 76:5<862-868x 1468-2060x 0003-4967
8564 u https://ard.bmj.com/content/annrheumdis/76/5/862.full.pdf
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:135467654
8564 8u https://doi.org/10.1136/annrheumdis-2016-210282

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