Subjective Oral Dryness following Hematopoietic Cell Transplantation: A Report from the Orastem Study

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Subjective Oral Dryness following Hematopoietic Cell Transplantation: A Report from the Orastem Study

Bulthuis, Marjolein S. (författare)

Leeuwen, Stephanie J. M. van (författare)

Thomas, Renske Z. (författare)

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Gennip, Lucky L. A. van (författare)

Whiteside, Heidi M. (författare)

Isom, Scott (författare)

Kline, David M. (författare)

Laheij, Alexa M. G. A. (författare)

Raber-Durlacher, Judith E. (författare)

Hasséus, Bengt, 1955 (författare): Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology

Johansson, Jan-Erik (författare)

Hovan, Allan J. (författare)

Brennan, Michael T. (författare)

von Bültzingslöwen, Inger, 1947 (författare): Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology

Huysmans, Marie -Charlotte D. N. J. M. (författare)

Blijlevens, Nicole M. A. (författare)

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2024
2024
Engelska.
Ingår i: TRANSPLANTATION AND CELLULAR THERAPY. - 2666-6375 .- 2666-6367. ; 30:4

Relaterad länk:: https://gup.ub.gu.se...; visa fler...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

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Xerostomia, or subjective oral dryness, is a serious complaint after hematopoietic cell transplantation (HCT). Xerostomia is rated as one of the most bothersome symptoms by HCT recipients, negatively affecting quality of life. This substudy of the Orastem study, prospective longitudinal, international, observational, multicenter study, aimed to describe the prevalence and severity of xerostomia following HCT. Furthermore, the effect of the conditioning regimen, type of transplantation, and oral mucosal changes related to chronic graft -versus -host disease (cGVHD) in the development of xerostomia were studied. All HCT recipients rated xerostomia on a scale of 0 to 10 before the conditioning regimen, several times early post-HCT, and at 3 months post-HCT, and only allogeneic HCT recipients also rated xerostomia at 6 and 12 months post-HCT. In addition, stimulated whole mouth saliva was collected several times. Linear regression models and longitudinal mixed-effects models were created to investigate the influence of indicators on xerostomia. A total of 99 autologous and 163 allogeneic HCT recipients were included from 6 study sites in Sweden, Canada, the Netherlands, and the United States. The prevalence of xerostomia was 40% before the conditioning regimen, 87% early post-HCT, and 64% at 3 months post-HCT. Complaints after autologous HCT were transient in nature, while the severity of xerostomia in allogeneic HCT recipients remained elevated at 12 months post-HCT. Compared to autologous HCT recipients, allogeneic HCT recipients experienced 1.0 point more xerostomia (95% confidence interval [CI], .1 to 2.0) early post-HCT and 1.7 points more (95% CI, .4 to 3.0) months post-HCT. Allogeneic HCT recipients receiving a high-intensity conditioning regimen experienced more xerostomia compared to those receiving a nonmyeloablative or reduced-intensity conditioning regimen. The difference was 2.0 points (95% CI, 1.1 to 2.9) early post-HCT, 1.8 points (95% CI, .3 to 3.3) after 3 months, and points (95% CI, .0 to 3.3) after 12 months. Total body irradiation as part of the conditioning regimen and oral mucosal changes related to cGVHD did not significantly influence the severity of xerostomia. Conditioning regimen intensity was a significant risk indicator in the development of xerostomia, whereas total body irradiation was not. Allogeneic HCT recipients experienced more xerostomia than autologous HCT recipients, a difference that cannot be explained by a reduction in stimulated salivary flow rate or the development of oral mucosal changes related to cGVHD.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)

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Av författaren/redakt...: Bulthuis, Marjol ...; Leeuwen, Stephan ...; Thomas, Renske Z ...; Gennip, Lucky L. ...; Whiteside, Heidi ...; Isom, Scott; visa fler...; Kline, David M.; Laheij, Alexa M. ...; Raber-Durlacher, ...; Hasséus, Bengt, ...; Johansson, Jan-E ...; Hovan, Allan J.; Brennan, Michael ...; von Bültzingslöw ...; Huysmans, Marie ...; Blijlevens, Nico ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Hematologi

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Av lärosätet: Göteborgs universitet

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