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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005006naa a2200505 4500
001oai:lup.lub.lu.se:f199dbd5-3e8c-452c-bdde-4c914faf67e7
003SwePub
008190527s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/f199dbd5-3e8c-452c-bdde-4c914faf67e72 URI
0247 a https://doi.org/10.1200/JCO.18.008222 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Pui, Ching-Honu University of Tennessee,St Jude Children´s Research Hospital, Memphis4 aut
2451 0a Outcome of Children With Hypodiploid Acute Lymphoblastic Leukemia : A Retrospective Multinational Study
264 1c 2019
300 a 10 s.
520 a PURPOSE: We determined the prognostic factors and utility of allogeneic hematopoietic cell transplantation among children with newly diagnosed hypodiploid acute lymphoblastic leukemia (ALL) treated in contemporary clinical trials.PATIENTS AND METHODS: This retrospective study collected data on 306 patients with hypodiploid ALL who were enrolled in the protocols of 16 cooperative study groups or institutions between 1997 and 2013. The clinical and biologic characteristics, early therapeutic responses as determined by minimal residual disease (MRD) assessment, treatment with or without MRD-stratified protocols, and allogeneic transplantation were analyzed for their impact on outcome.RESULTS: With a median follow-up of 6.6 years, the 5-year event-free survival rate was 55.1% (95% CI, 49.3% to 61.5%), and the 5-year overall survival rate was 61.2% (95% CI, 55.5% to 67.4%) for the 272 evaluable patients. Negative MRD at the end of remission induction, high hypodiploidy with 44 chromosomes, and treatment in MRD-stratified protocols were associated with a favorable prognosis, with a 5-year event-free survival rate of 75% (95% CI, 66.0% to 85.0%), 74% (95% CI, 61.0% to 89.0%), and 62% (95% CI, 55.0% to 69.0%), respectively. After exclusion of patients with high hypodiploidy with 44 chromosomes and adjustment for waiting time to transplantation and for covariables in a Poisson model, disease-free survival did not differ significantly ( P = .16) between the 42 patients who underwent transplantation and the 186 patients who received chemotherapy only, with an estimated 5-year survival rate of 59% (95% CI, 46.5% to 75.0%) versus 51.5% (95% CI, 44.7% to 59.4%), respectively. Transplantation produced no significant impact on outcome compared with chemotherapy alone, especially among the subgroup of patients who achieved a negative MRD status upon completion of remission induction.CONCLUSION: MRD-stratified treatments improved the outcome for children with hypodiploid ALL. Allogeneic transplantation did not significantly improve outcome overall and, in particular, for patients who achieved MRD-negative status after induction.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
7001 a Rebora, Paolau University of Milano-Bicocca4 aut
7001 a Schrappe, Martinu University Medical Center Schleswig-Holstein,University of Kiel4 aut
7001 a Attarbaschi, Andisheu Medical University of Vienna4 aut
7001 a Baruchel, Andreu Paris Diderot University4 aut
7001 a Basso, Giuseppeu University of Padova4 aut
7001 a Cavé, Hélèneu Paris Diderot University4 aut
7001 a Elitzur, Sarahu Tel-Aviv University4 aut
7001 a Koh, Katsuyoshiu Saitama Children's Medical Center4 aut
7001 a Liu, Hsi-Cheu MacKay Memorial Hospital4 aut
7001 a Paulsson, Kajsau Lund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)kgen-kpa
7001 a Pieters, Robu Princess Maxima Center for Pediatric Oncology/Hematology4 aut
7001 a Silverman, Lewis Bu Dana-Farber Cancer Institute,Boston Children's Hospital4 aut
7001 a Stary, Janu University Hospital Motol,Charles University in Prague4 aut
7001 a Vora, Ajayu Great Ormond Street Hospital4 aut
7001 a Yeoh, Allenu National University of Singapore4 aut
7001 a Harrison, Christine Ju University of Newcastle upon Tyne4 aut
7001 a Valsecchi, Maria Graziau University of Milano-Bicocca4 aut
7102 a University of Tennesseeb St Jude Children´s Research Hospital, Memphis4 org
7102 a Ponte di Legno Childhood ALL Working Group
7730 t Journal of Clinical Oncologyg 37:10, s. 770-779q 37:10<770-779x 0732-183X
8564 u http://dx.doi.org/10.1200/JCO.18.00822y FULLTEXT
8564 8u https://lup.lub.lu.se/record/f199dbd5-3e8c-452c-bdde-4c914faf67e7
8564 8u https://doi.org/10.1200/JCO.18.00822

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