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  • Theorell, TöresKarolinska Institutet,Stockholms universitet,Stressforskningsinstitutet (författare)

Obesity and loss of disease-free years owing to major non-communicable diseases : a multicohort study

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • Elsevier Ltd,2018
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-16346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-16346URI
  • https://doi.org/10.1016/S2468-2667(18)30139-7DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-152989URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-34908URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-41992URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-162021URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:139787819URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-362394URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CC BY 4.0
  • FUNDING: NordForsk, UK Medical Research Council, US National Institute on Aging, Academy of Finland, Helsinki Institute of Life Science, and Cancer Research UK.
  • Background: Obesity increases the risk of several chronic diseases, but the extent to which the obesity-related loss of disease-free years varies by lifestyle category and across socioeconomic groups is unclear. We estimated the number of years free from major non-communicable diseases in adults who are overweight and obese, compared with those who are normal weight. Methods: We pooled individual-level data on body-mass index (BMI) and non-communicable diseases from men and women with no initial evidence of these diseases in European cohort studies from the Individual-Participant-Data Meta-Analysis in Working Populations consortium. BMI was assessed at baseline (1991–2008) and non-communicable diseases (incident type 2 diabetes, coronary heart disease, stroke, cancer, asthma, and chronic obstructive pulmonary disease) were ascertained via linkage to records from national health registries, repeated medical examinations, or self-report. Disease-free years from age 40 years to 75 years associated with underweight (BMI <18·5 kg/m2), overweight (≥25 kg/m2 to <30 kg/m2), and obesity (class I [mild] ≥30 kg/m2 to <35 kg/m2; class II–III [severe] ≥35 kg/m2) compared with normal weight (≥18·5 kg/m2 to <25 kg/m2) were estimated. Findings: Of 137 503 participants from ten studies, we excluded 6973 owing to missing data and 10 349 with prevalent disease at baseline, resulting in an analytic sample of 120 181 participants. Of 47 127 men, 211 (0·4%) were underweight, 21 468 (45·6%) normal weight, 20 738 (44·0%) overweight, 3982 (8·4%) class I obese, and 728 (1·5%) class II–III obese. The corresponding numbers among the 73 054 women were 1493 (2·0%), 44 760 (61·3%), 19 553 (26·8%), 5670 (7·8%), and 1578 (2·2%), respectively. During 1 328 873 person-years at risk (mean follow-up 11·5 years [range 6·3–18·6]), 8159 men and 8100 women developed at least one non-communicable disease. Between 40 years and 75 years, the estimated number of disease-free years was 29·3 (95% CI 28·8–29·8) in normal-weight men and 29·4 (28·7–30·0) in normal-weight women. Compared with normal weight, the loss of disease-free years in men was 1·8 (95% CI −1·3 to 4·9) for underweight, 1·1 (0·7 to 1·5) for overweight, 3·9 (2·9 to 4·9) for class I obese, and 8·5 (7·1 to 9·8) for class II–III obese. The corresponding estimates for women were 0·0 (−1·4 to 1·4) for underweight, 1·1 (0·6 to 1·5) for overweight, 2·7 (1·5 to 3·9) for class I obese, and 7·3 (6·1 to 8·6) for class II–III obese. The loss of disease-free years associated with class II–III obesity varied between 7·1 and 10·0 years in subgroups of participants of different socioeconomic level, physical activity level, and smoking habit. Interpretation: Mild obesity was associated with the loss of one in ten, and severe obesity the loss of one in four potential disease-free years during middle and later adulthood. This increasing loss of disease-free years as obesity becomes more severe occurred in both sexes, among smokers and non-smokers, the physically active and inactive, and across the socioeconomic hierarchy. Funding: NordForsk, UK Medical Research Council, US National Institute on Aging, Academy of Finland, Helsinki Institute of Life Science, and Cancer Research UK. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Batty, George DavidDepartment of Epidemiology and Public Health, University College London, London, UK,UCL, London, England (författare)
  • Pentti, JaanaClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Finland / Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland,Univ Helsinki, Helsinki, Finland; Univ Turku, Turku, Finland; Turku Univ Hosp, Turku, Finland (författare)
  • Virtanen, MariannaUppsala universitet,Stockholms universitet,Stressforskningsinstitutet,Finnish Institute of Occupational Health, Finland; Uppsala University, Sweden,Folkhälsovetenskap(Swepub:uu)marvi534 (författare)
  • Suominen, SakariHögskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland,Individ och samhälle VIDSOC(Swepub:his)suos (författare)
  • Fransson, Eleonor I.,1971-Stockholms universitet,Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT,HHJ. ARN-J (Aging Research Network - Jönköping),Stress Research Institute, University of Stockholm, Sweden / School of Health and Welfare, Jönköping University, Jönköping, Sweden,Stressforskningsinstitutet(Swepub:hj)Frel (författare)
  • Goldberg, MarcelParis Descartes University, Paris, France / Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France (författare)
  • Heikkilä, Katriina V.Department of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, United Kingdom / Clinical Effectiveness Unit, The Royal College of Surgeons, London, United Kingdom,London Sch Hyg & Trop Med, London, England; Royal Coll Surgeons England, London, England (författare)
  • Jokela, MarkusDepartment of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Helsinki, Finland,Uppsala Univ, Uppsala; Univ Stockholm, Stockholm,Department of Medical Sciences, Uppsala University, Uppsala, Sweden,Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Finland (författare)
  • Knutsson, Anders,1942-Mittuniversitetet,Avdelningen för hälsovetenskap,Department of Health Sciences, Mid Sweden University, Sundsvall, Sweden(Swepub:miun)andknu (författare)
  • Koskenvuo, Markku J.Clinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Helsinki, Finland (författare)
  • Lallukka, TeaClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Finland / Finnish Institute of Occupational Health, Finland,Univ Helsinki, Helsinki, Finland; Finnish Inst Occupat Hlth, Helsinki, Finland (författare)
  • Leineweber, ConstanzeStockholms universitet,Stressforskningsinstitutet(Swepub:su)clein (författare)
  • Lindbohm, Joni ValdemarClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Helsinki, Finland (författare)
  • Madsen, Ida E. H.National Research Centre for the Working Environment, Copenhagen, Denmark,Natl Res Ctr Working Environm, Copenhagen, Denmark (författare)
  • Magnusson Hanson, Linda L.Stockholms universitet,Stressforskningsinstitutet(Swepub:su)linma (författare)
  • Nordin, MariaStockholms universitet,Umeå universitet,Institutionen för psykologi,Univ Stockholm, Stockholm; Umeå Univ, Umeå,Stress Research Institute, University of Stockholm, Sweden / Department of Psychology, Umeå University, Umeå, Sweden,Stressforskningsinstitutet(Swepub:umu)nonmaa98 (författare)
  • Oksanen, TuulaFinnish Institute of Occupational Health, Helsinki, Finland,Finnish Inst Occupat Hlth, Helsinki, Finland (författare)
  • Pietiläinen, OlliClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Helsinki, Finland (författare)
  • Rahkonen, OssiClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland,Univ Helsinki, Helsinki, Finland (författare)
  • Rugulies, ReinerNational Research Centre for the Working Environment, Copenhagen, Denmark; Department of Public Health and Department of Psychology, University of Copenhagen, Denmark,Natl Res Ctr Working Environm, Copenhagen, Denmark; Univ Copenhagen, Copenhagen, Denmark (författare)
  • Shipley, Martin J.Department of Epidemiology and Public Health, University College London, London, UK,UCL, London, England; INSERM, Villejuif, France (författare)
  • Stenholm, SariDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Faculty of Social Sciences (Health Sciences), University of Tampere, Finland (författare)
  • Suominen, SakariHögskolan i Skövde,Institutionen för hälsa och lärande,Forskningsspecialiseringen Hälsa och Lärande,Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland,Individ och samhälle VIDSOC(Swepub:his)suos (författare)
  • Theorell, TöresStress Research Institute, University of Stockholm, Sweden (författare)
  • Vahtera, JussiDepartment of Public Health, University of Turku and Turku University Hospital, Turku, Finland,Univ Turku, Turku, Finland; Turku Univ Hosp, Turku, Finland (författare)
  • Westerholm, PeterUppsala universitet,Arbets- och miljömedicin(Swepub:uu)petwe427 (författare)
  • Westerlund, HugoStockholms universitet,Stressforskningsinstitutet(Swepub:su)hwest (författare)
  • Zins, MarieParis Descartes University, Paris, France / Inserm UMS 011, Population-Based Epidemiological Cohorts Unit, Villejuif, France (författare)
  • Hamer, MarkNational Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, UK,Loughborough Univ Technol, Loughborough, Leics, England (författare)
  • Singh-Manoux, ArchanaDepartment of Epidemiology and Public Health, University College London, London, UK / Inserm U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France,UCL, London, England (författare)
  • Bell, Jousha A.MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK,Univ Bristol, MRC, Bristol, Avon, England (författare)
  • Ferrie, Jane E.Department of Epidemiology and Public Health, University College London, London, UK / Bristol Medical School: Population Health Sciences, University of Bristol, UK,UCL, London, England; Univ Bristol, Bristol, Avon, England (författare)
  • Kivimäki, MikaClinicum, Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland / Department of Epidemiology and Public Health, University College London, UK,Univ Helsinki, Helsinki, Finland; UCL, London, England (författare)
  • Alfredsson, LarsKarolinska Institutet (författare)
  • Nyberg, Solja (författare)
  • Stockholms universitetStressforskningsinstitutet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:The Lancet Public Health: Elsevier Ltd3:10, s. e490-e4972468-2667

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