Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder

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Fältnamn	Indikatorer	Metadata
000		03838naa a2200445 4500
001		oai:lup.lub.lu.se:b1086644-4f64-445a-b092-283eb455e762
003		SwePub
008		160401s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:129071919
024	7	a https://lup.lub.lu.se/record/45594122 URI
024	7	a https://doi.org/10.1017/S00332917130015292 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1290719192 URI
040		a (SwePub)lud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Haukvik, U. K.4 aut
245	1 0	a Pre- and perinatal hypoxia associated with hippocampus/amygdala volume in bipolar disorder
264	1	c 2014
520		a Background Pre- and perinatal adversities may increase the risk for schizophrenia and bipolar disorder. Hypoxia-related obstetric complications (OCs) are associated with brain anatomical abnormalities in schizophrenia, but their association with brain anatomy variation in bipolar disorder is unknown. Method Magnetic resonance imaging brain scans, clinical examinations and data from the Medical Birth Registry of Norway were obtained for 219 adults, including 79 patients with a DSM-IV diagnosis of bipolar disorder (age 29.4 years, s.d.=11.8 years, 39% male) and 140 healthy controls (age 30.8 years, s.d.=12.0 years, 53% male). Severe hypoxia-related OCs throughout pregnancy/birth and perinatal asphyxia were each studied in relation to a priori selected brain volumes (hippocampus, lateral ventricles and amygdala, obtained with FreeSurfer), using linear regression models covarying for age, sex, medication use and intracranial volume. Multiple comparison adjustment was applied. Results Perinatal asphyxia was associated with smaller left amygdala volume (t=-2.59, p=0.012) in bipolar disorder patients, but not in healthy controls. Patients with psychotic bipolar disorder showed distinct associations between perinatal asphyxia and smaller left amygdala volume (t=-2.69, p=0.010), whereas patients with non-psychotic bipolar disorder showed smaller right hippocampal volumes related to both perinatal asphyxia (t=-2.60, p=0.015) and severe OCs (t=-3.25, p=0.003). No associations between asphyxia or severe OCs and the lateral ventricles were found. Conclusions Pre- and perinatal hypoxia-related OCs are related to brain morphometry in bipolar disorder in adulthood, with specific patterns in patients with psychotic versus non-psychotic illness.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
653		a MRI
653		a neurodevelopment
653		a neuroimaging
653		a obstetric complications
653		a psychosis
700	1	a McNeil, Thomasu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)smi-tmc
700	1	a Lange, E. H.4 aut
700	1	a Melle, I.4 aut
700	1	a Dale, A. M.4 aut
700	1	a Andreassen, O. A.4 aut
700	1	a Agartz, I.u Karolinska Institutet4 aut
710	2	a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org
773	0	t Psychological Medicineg 44:5, s. 975-985q 44:5<975-985x 1469-8978
856	4	u http://dx.doi.org/10.1017/S0033291713001529x freey FULLTEXT
856	4 8	u https://lup.lub.lu.se/record/4559412
856	4 8	u https://doi.org/10.1017/S0033291713001529
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:129071919

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Av författaren/redakt...: Haukvik, U. K.; McNeil, Thomas; Lange, E. H.; Melle, I.; Dale, A. M.; Andreassen, O. A ...; visa fler...; Agartz, I.; visa färre...

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