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Analysis of Genetic...
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Link, Verena MDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Faculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of Munich, Munich, Germany
(författare)
Analysis of Genetically Diverse Macrophages Reveals Local and Domain-wide Mechanisms that Control Transcription Factor Binding and Function.
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
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Cambridge, United States :Cell Press,2018
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:liu-154607
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154607URI
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https://doi.org/10.1016/j.cell.2018.04.018DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Non-coding genetic variation is a major driver of phenotypic diversity and allows the investigation of mechanisms that control gene expression. Here, we systematically investigated the effects of >50 million variations from five strains of mice on mRNA, nascent transcription, transcription start sites, and transcription factor binding in resting and activated macrophages. We observed substantial differences associated with distinct molecular pathways. Evaluating genetic variation provided evidence for roles of ∼100 TFs in shaping lineage-determining factor binding. Unexpectedly, a substantial fraction of strain-specific factor binding could not be explained by local mutations. Integration of genomic features with chromatin interaction data provided evidence for hundreds of connected cis-regulatory domains associated with differences in transcription factor binding and gene expression. This system and the >250 datasets establish a substantial new resource for investigation of how genetic variation affects cellular phenotypes.
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Duttke, Sascha HDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Chun, Hyun BDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Holtman, Inge RDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
(författare)
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Westin, EmmaDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Hoeksema, Marten ADepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Abe, YoheiDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Skola, DylanDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Romanoski, Casey EDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA
(författare)
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Tao, JenhanDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Fonseca, Gregory JDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Troutman, Ty DDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Spann, Nathanael JDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Strid, TobiasDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA(Swepub:liu)tobst76
(författare)
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Sakai, MashitoDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Yu, MiaoLudwig Institute for Cancer Research, La Jolla, CA, USA
(författare)
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Hu, RongLudwig Institute for Cancer Research, La Jolla, CA, USA
(författare)
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Fang, RongxinLudwig Institute for Cancer Research, La Jolla, CA, USA
(författare)
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Metzler, DirkFaculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of Munich, Munich, Germany
(författare)
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Ren, BingDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Ludwig Institute for Cancer Research, La Jolla, CA, USA
(författare)
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Glass, Christopher KDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA
(författare)
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Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA; Faculty of Biology, Division of Evolutionary Biology, Ludwig-Maximilian University of Munich, Munich, GermanyDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:CellCambridge, United States : Cell Press173:7, s. 1796-1809.e170092-86741097-4172
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Cell
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- Av författaren/redakt...
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Link, Verena M
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Duttke, Sascha H
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Chun, Hyun B
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Holtman, Inge R
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Westin, Emma
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Hoeksema, Marten ...
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visa fler...
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Abe, Yohei
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Skola, Dylan
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Romanoski, Casey ...
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Tao, Jenhan
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Fonseca, Gregory ...
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Troutman, Ty D
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Spann, Nathanael ...
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Strid, Tobias
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Sakai, Mashito
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Yu, Miao
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Hu, Rong
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Fang, Rongxin
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Metzler, Dirk
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Ren, Bing
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Glass, Christoph ...
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