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The CHEK2 1100delC ...
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Djureinovic, Tatjana
(author)
The CHEK2 1100delC variant in Swedish colorectal cancer
- Article/chapterEnglish2006
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-11118
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11118URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-8174URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-11843URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1962049URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: The cell cycle checkpoint kinase 2 (CHEK2) 1100delC variant has recently been identified at high frequency in families with both breast and colorectal cancer, suggesting the possible role of this variant in colorectal cancer predisposition. PATIENTS AND METHODS: To evaluate the role of CHEK2 ll00delC among Swedish colorectal cancer patients, the variant frequency was determined in 174 selected familial cases, 644 unselected cases and 760 controls, as well as in l8 families used in the genome-wide linkage analysis, where weak linkage was seen for the region harboring the CHEK2 gene. RESULTS: CHEK2 l100delC was found in 1.15% of familial and in 0.93% of unselected cases, compared to 0.66% of controls, showing no significant difference between groups. One out of 45 familial cases with a family history of breast cancer was shown to be a carrier. The variant was not identified in the 18 families included in the linkage analysis. CONCLUSION: The CHEK2 1100delC was not significantly increased in Swedish colorectal cancer patients, however, in order to determine the role of the variant in colorectal cancer families with the history of breast cancer a larger sample size is needed.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Lindblom, AnnikaKarolinska Institutet
(author)
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Dalén, Johan
(author)
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Dedorson, Stefan
(author)
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Edler, DavidKarolinska Institutet
(author)
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Hjern, FredrikKarolinska Institutet
(author)
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Holm, Jörn
(author)
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Lenander, ClaesKarolinska Institutet
(author)
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Lindforss, UlrikKarolinska Institutet
(author)
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Lundqvist, Nils
(author)
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Olivecrona, Hans
(author)
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Olsson, LouiseKarolinska Institutet
(author)
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Påhlman, LarsUppsala universitet,Institutionen för kirurgiska vetenskaper,Gastrointestinal surgery(Swepub:uu)larspahl
(author)
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Rutegård, JörgenUmeå universitet,Örebro universitet,Hälsoakademin,Kirurgi(Swepub:umu)jaru0001
(author)
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Smedh, Kennet
(author)
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Törnqvist, Anders
(author)
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Eiberg, Hans
(author)
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Bisgaard, Marie Luise
(author)
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Karolinska InstitutetInstitutionen för kirurgiska vetenskaper
(creator_code:org_t)
Related titles
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In:Anticancer Research26:6C, s. 4885-48880250-70051791-7530
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- By the author/editor
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Djureinovic, Tat ...
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Lindblom, Annika
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Dalén, Johan
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Dedorson, Stefan
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Edler, David
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Hjern, Fredrik
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show more...
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Holm, Jörn
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Lenander, Claes
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Lindforss, Ulrik
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Lundqvist, Nils
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Olivecrona, Hans
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Olsson, Louise
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Påhlman, Lars
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Rutegård, Jörgen
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Smedh, Kennet
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Törnqvist, Ander ...
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Eiberg, Hans
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Bisgaard, Marie ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Anticancer Resea ...
- By the university
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Örebro University
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Umeå University
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Uppsala University
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Karolinska Institutet