Sökning: (LAR1:uu) srt2:(2005-2009) > (2009) > High cyclin B1 expr...
Fältnamn | Indikatorer | Metadata |
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000 | 03259naa a2200457 4500 | |
001 | oai:DiVA.org:uu-105531 | |
003 | SwePub | |
008 | 090604s2009 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:118532857 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1055312 URI |
024 | 7 | a https://doi.org/10.1038/sj.bjc.66048742 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1185328572 URI |
040 | a (SwePub)uud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Aaltonen, Kirsimari4 aut |
245 | 1 0 | a High cyclin B1 expression is associated with poor survival in breast cancer |
264 | c 2009-03-17 | |
264 | 1 | b Springer Science and Business Media LLC,c 2009 |
338 | a print2 rdacarrier | |
520 | a Cyclin B1 regulates the G(2)-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological variables and prognostic role in breast cancer are not fully understood. Traditionally used prognostic criteria identify large subset of patients to receive adjuvant chemotherapy and to be exposed to adverse effects. A reliable and simple method helping prognostic evaluation in breast cancer is needed. We analysed cyclin B1 expression on 1348 invasive breast cancers and studied correlations with other histopathological variables and survival. High cyclin B1 correlated with high tumour grade, large tumour size and positive nodal status, oestrogen and progesterone receptor negativity, positive HER2 and p53 status, young age at diagnosis, and high cyclin E, cyclin A and Ki67 expression. Among patients not given adjuvant chemotherapy high cyclin B1 was a strong predictor of shorter overall and metastasis-free survival (RR 3.74, P<0.0005 and RR 3.51, P<0.0005, respectively), and remained as an independent prognostic factor also in multivariate analysis (RR 1.80, P=0.04 and RR 2.31, P=0.02, respectively). This study suggests high cyclin B1 associates with aggressive phenotype and is an independent prognostic factor in breast cancer. | |
653 | a breast cancer | |
653 | a cyclin B1 | |
653 | a survival | |
653 | a prognosis | |
653 | a MEDICINE | |
653 | a MEDICIN | |
700 | 1 | a Amini, Rose-Marieu Karolinska Institutet,Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)roseamin |
700 | 1 | a Heikkilä, Päivi4 aut |
700 | 1 | a Aittomäki, Kristiina4 aut |
700 | 1 | a Tamminen, A.4 aut |
700 | 1 | a Nevanlinna, Heli4 aut |
700 | 1 | a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut |
710 | 2 | a Uppsala universitetb Institutionen för immunologi, genetik och patologi4 org |
773 | 0 | t British Journal of Cancerd : Springer Science and Business Media LLCg 100:7, s. 1055-60q 100:7<1055-60x 0007-0920x 1532-1827 |
856 | 4 | u https://www.nature.com/articles/6604874.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105531 |
856 | 4 8 | u https://doi.org/10.1038/sj.bjc.6604874 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:118532857 |
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