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(WFRF:(Bruce Ian N.)) lar1:(lu) pers:(Isenberg David A.) pers:(Mackay Meggan)
 

Sökning: (WFRF:(Bruce Ian N.)) lar1:(lu) pers:(Isenberg David A.) pers:(Mackay Meggan) > Headache in Systemi...

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FältnamnIndikatorerMetadata
00005995naa a2200829 4500
001oai:lup.lub.lu.se:0eef268f-78ad-4421-a0dc-3554f7ed8179
003SwePub
008160401s2013 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:127620419
0247 a https://lup.lub.lu.se/record/42125432 URI
0247 a https://doi.org/10.1002/art.381062 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1276204192 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Hanly, John G.4 aut
2451 0a Headache in Systemic Lupus Erythematosus Results From a Prospective, International Inception Cohort Study
264 c 2013-10-28
264 1b Wiley,c 2013
520 a ObjectiveTo examine the frequency and characteristics of headaches and their association with global disease activity and health-related quality of life (HRQOL) in patients with systemic lupus erythematosus (SLE). MethodsA disease inception cohort was assessed annually for headache (5 types) and 18 other neuropsychiatric (NP) events. Global disease activity scores (SLE Disease Activity Index 2000 [SLEDAI-2K]), damage scores (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]), and Short Form 36 (SF-36) mental and physical component summary scores were collected. Time to first headache and associations with SF-36 scores were analyzed using Cox proportional hazards and linear regression models with generalized estimating equations. ResultsAmong the 1,732 SLE patients enrolled, 89.3% were female and 48.3% were white. The mean SD age was 34.6 +/- 13.4 years, duration of disease was 5.6 +/- 5.2 months, and length of followup was 3.8 +/- 3.1 years. At enrollment, 17.8% of patients had headache (migraine [60.7%], tension [38.6%], intractable nonspecific [7.1%], cluster [2.6%], and intracranial hypertension [1.0%]). The prevalence of headache increased to 58% after 10 years. Only 1.5% of patients had lupus headache, as identified in the SLEDAI-2K. In addition, headache was associated with other NP events attributed to either SLE or non-SLE causes. There was no association of headache with SLEDAI-2K scores (without the lupus headache variable), SDI scores, use of corticosteroids, use of antimalarials, use of immunosuppressive medications, or specific autoantibodies. SF-36 mental component scores were lower in patients with headache compared with those without headache (mean +/- SD 42.5 +/- 12.2 versus 47.8 +/- 11.3; P < 0.001), and similar differences in physical component scores were seen (38.0 +/- 11.0 in those with headache versus 42.6 +/- 11.4 in those without headache; P < 0.001). In 56.1% of patients, the headaches resolved over followup. ConclusionHeadache is frequent in SLE, but overall, it is not associated with global disease activity or specific autoantibodies. Although headaches are associated with a lower HRQOL, the majority of headaches resolve over time, independent of lupus-specific therapies.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
7001 a Urowitz, Murray B.4 aut
7001 a O'Keeffe, Aidan G.4 aut
7001 a Gordon, Caroline4 aut
7001 a Bae, Sang-Cheol4 aut
7001 a Sanchez-Guerrero, Jorge4 aut
7001 a Romero-Diaz, Juanita4 aut
7001 a Clarke, Ann E.4 aut
7001 a Bernatsky, Sasha4 aut
7001 a Wallace, Daniel J.4 aut
7001 a Ginzler, Ellen M.4 aut
7001 a Isenberg, David A.4 aut
7001 a Rahman, Anisur4 aut
7001 a Merrill, Joan T.4 aut
7001 a Petri, Michelle4 aut
7001 a Fortin, Paul R.4 aut
7001 a Gladman, Dafna D.4 aut
7001 a Fessler, Barri J.4 aut
7001 a Alarcon, Graciela S.4 aut
7001 a Bruce, Ian N.4 aut
7001 a Dooley, Mary Anne4 aut
7001 a Steinsson, Kristjan4 aut
7001 a Khamashta, Munther A.4 aut
7001 a Ramsey-Goldman, Rosalind4 aut
7001 a Manzi, Susan4 aut
7001 a Sturfelt, Gunnaru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-gst
7001 a Nived, Olau Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)reum-oni
7001 a Zoma, Asad A.4 aut
7001 a van Vollenhoven, Ronald F.u Karolinska Institutet4 aut
7001 a Ramos-Casals, Manuel4 aut
7001 a Aranow, Cynthia4 aut
7001 a Mackay, Meggan4 aut
7001 a Ruiz-Irastorza, Guillermo4 aut
7001 a Kalunian, Kenneth C.4 aut
7001 a Lim, S. Sam4 aut
7001 a Inanc, Murat4 aut
7001 a Kamen, Diane L.4 aut
7001 a Peschken, Christine A.4 aut
7001 a Jacobsen, Soren4 aut
7001 a Theriault, Chris4 aut
7001 a Thompson, Kara4 aut
7001 a Farewell, Vernon4 aut
7102 a Reumatologi och molekylär skelettbiologib Sektion III4 org
7730 t Arthritis and Rheumatismd : Wileyg 65:11, s. 2887-2897q 65:11<2887-2897x 1529-0131x 0004-3591
8564 u http://dx.doi.org/10.1002/art.38106y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.38106
8564 8u https://lup.lub.lu.se/record/4212543
8564 8u https://doi.org/10.1002/art.38106
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:127620419

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