Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: Results from a randomized clinical trial

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Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: Results from a randomized clinical trial

Koffert, J. P. (författare): Turku PET Centre,Turunmaa Hospital,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.;Southwest Finland Hosp Dist, Turunmaa Hosp, Dept Gastroenterol, Turku, Finland.

Mikkola, K. (författare): Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.

Virtanen, K. A. (författare): Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.

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Andersson, A. M. D. (författare): Lund Univ, Dept Clin Sci Malmo, Diabet Ctr, Malmo, Sweden.

Faxius, Linda (författare): Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Diabet Ctr, Malmo, Sweden.

Hällsten, K. (författare): Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.

Heglind, Mikael, 1975 (författare): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Clin & Med Genet, SE-40530 Gothenburg, Sweden.

Guiducci, L. (författare): CNR Institute of Clinical Physiology (IFC-CNR),CNR, Inst Clin Physiol, Pisa, Italy.

Pham, T. (författare): Turku PET Centre

Silvola, J. M. U. (författare): Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.

Virta, J. (författare): Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.

Eriksson, Olof (författare): Uppsala universitet,Uppsala University,Turku PET Centre,Åbo Akademi University,Institutionen för läkemedelskemi,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.;Abo Akad Univ, Dept Biosci, Turku, Finland.

Kauhanen, S. P. (författare): Turku PET Centre,Turku University Hospital,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.;Turku Univ Hosp, Div Digest Surg & Urol, Turku, Finland.

Saraste, A. (författare): Turku PET Centre,Turku University Hospital,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.;Turku Univ Hosp, Heart Ctr, Turku, Finland.

Enerbäck, Sven, 1958 (författare): University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för biomedicin,Institute of Biomedicine,Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Clin & Med Genet, SE-40530 Gothenburg, Sweden.

Iozzo, P. (författare): CNR Institute of Clinical Physiology (IFC-CNR),CNR, Inst Clin Physiol, Pisa, Italy.

Parkkola, R. (författare): University of Turku,Turku University Hospital,Turku Univ, Dept Radiol, Turku, Finland.;Turku Univ Hosp, Dept Radiol, Turku, Finland.

Gomez, Maria F. (författare): Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups,Lund Univ, Dept Clin Sci Malmo, Diabet Ctr, Malmo, Sweden.

Nuutila, P. (författare): Turku University Hospital,Turku PET Centre,Univ Turku, Turku PET Ctr, PL52, FIN-20520 Turku, Finland.;Turku Univ Hosp, Dept Endocrinol, Turku, Finland.

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Elsevier BV, 2017
2017
Engelska.
Ingår i: Diabetes Research and Clinical Practice. - : Elsevier BV. - 0168-8227 .- 1872-8227. ; 131, s. 208-216

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Aims Metformin therapy is associated with diffuse intestinal 18F-fluoro-deoxyglucose (FDG) accumulation in clinical diagnostics using routine FDG-PET imaging. We aimed to study whether metformin induced glucose uptake in intestine is associated with the improved glycaemic control in patients with type 2 diabetes. Therefore, we compared the effects of metformin and rosiglitazone on intestinal glucose metabolism in patients with type 2 diabetes in a randomized placebo controlled clinical trial, and further, to understand the underlying mechanism, evaluated the effect of metformin in rats. Methods Forty-one patients with newly diagnosed type 2 diabetes were randomized to metformin (1g, b.i.d), rosiglitazone (4mg, b.i.d), or placebo in a 26-week double-blind trial. Tissue specific intestinal glucose uptake was measured before and after the treatment period using FDG-PET during euglycemic hyperinsulinemia. In addition, rats were treated with metformin or vehicle for 12weeks, and intestinal FDG uptake was measured in vivo and with autoradiography. Results Glucose uptake increased 2-fold in the small intestine and 3-fold in the colon for the metformin group and associated with improved glycemic control. Rosiglitazone increased only slightly intestinal glucose uptake. In rodents, metformin treatment enhanced intestinal FDG retention (P=0.002), which was localized in the mucosal enterocytes of the small intestine. Conclusions Metformin treatment significantly enhances intestinal glucose uptake from the circulation of patients with type 2 diabetes. This intestine-specific effect is associated with improved glycemic control and localized to mucosal layer. These human findings demonstrate directs effect of metformin on intestinal metabolism and elucidate the actions of metformin. Clinical trial number NCT02526615 © 2017 The Authors

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Endokrinologi oc ...

Artiklar i publikationen: Diabetes Researc ...

Av lärosätet: Göteborgs universitet; Lunds universitet; Uppsala universitet

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Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: Results from a randomized clinical trial

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