Sökning: (WFRF:(Glazer Nicole L.)) > CUBN Is a Gene Locu...
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000 | 07561naa a2201753 4500 | |
001 | oai:DiVA.org:uu-151658 | |
003 | SwePub | |
008 | 110415s2011 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:122240148 | |
009 | oai:dalea.du.se:5794 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1516582 URI |
024 | 7 | a https://doi.org/10.1681/ASN.20100605982 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1222401482 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-57942 URI |
040 | a (SwePub)uud (SwePub)kid (SwePub)du | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Boeger, Carsten A.4 aut |
245 | 1 0 | a CUBN Is a Gene Locus for Albuminuria |
264 | 1 | c 2011 |
338 | a print2 rdacarrier | |
520 | a Identification of genetic risk factors for albuminuria may alter strategies for early prevention of CKD progression, particularly among patients with diabetes. Little is known about the influence of common genetic variants on albuminuria in both general and diabetic populations. We performed a meta-analysis of data from 63,153 individuals of European ancestry with genotype information from genome-wide association studies (CKDGen Consortium) and from a large candidate gene study (CARe Consortium) to identify susceptibility loci for the quantitative trait urinary albumin-to-creatinine ratio (UACR) and the clinical diagnosis microalbuminuria. We identified an association between a missense variant (I2984V) in the CUBN gene, which encodes cubilin, and both UACR (P = 1.1 x 10(-11)) and microalbuminuria (P = 0.001). We observed similar associations among 6981 African Americans in the CARe Consortium. The associations between this variant and both UACR and microalbuminuria were significant in individuals of European ancestry regardless of diabetes status. Finally, this variant associated with a 41% increased risk for the development of persistent microalbuminuria during 20 years of follow-up among 1304 participants with type 1 diabetes in the prospective DCCT/EDIC Study. In summary, we identified a missense CUBN variant that associates with levels of albuminuria in both the general population and in individuals with diabetes. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
653 | a MEDICINE | |
653 | a MEDICIN | |
653 | a Hälsa och välfärd | |
700 | 1 | a Chen, Ming-Huei4 aut |
700 | 1 | a Tin, Adrienne4 aut |
700 | 1 | a Olden, Matthias4 aut |
700 | 1 | a Koettgen, Anna4 aut |
700 | 1 | a de Boer, Ian H.4 aut |
700 | 1 | a Fuchsberger, Christian4 aut |
700 | 1 | a O'Seaghdha, Conall M.4 aut |
700 | 1 | a Pattaro, Cristian4 aut |
700 | 1 | a Teumer, Alexander4 aut |
700 | 1 | a Liu, Ching-Ti4 aut |
700 | 1 | a Glazer, Nicole L.4 aut |
700 | 1 | a Li, Man4 aut |
700 | 1 | a O'Conne, Jeffrey R.4 aut |
700 | 1 | a Tanaka, Toshiko4 aut |
700 | 1 | a Peralta, Carmen A.4 aut |
700 | 1 | a Kutalik, Zoltan4 aut |
700 | 1 | a Luan, Jian'an4 aut |
700 | 1 | a Zhao, Jing Hua4 aut |
700 | 1 | a Hwang, Shih-Jen4 aut |
700 | 1 | a Akylbekova, Ermeg4 aut |
700 | 1 | a Kramer, Holly4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Smith, Albert V.4 aut |
700 | 1 | a Lohman, Kurt4 aut |
700 | 1 | a de Andrade, Mariza4 aut |
700 | 1 | a Hayward, Caroline4 aut |
700 | 1 | a Kollerits, Barbara4 aut |
700 | 1 | a Toenjes, Anke4 aut |
700 | 1 | a Aspelund, Thor4 aut |
700 | 1 | a Ingelsson, Eriku Karolinska Institutet4 aut |
700 | 1 | a Eiriksdottir, Gudny4 aut |
700 | 1 | a Launer, Lenore J.4 aut |
700 | 1 | a Harris, Tamara B.4 aut |
700 | 1 | a Shuldiner, Alan R.4 aut |
700 | 1 | a Mitchell, Braxton D.4 aut |
700 | 1 | a Arking, Dan E.4 aut |
700 | 1 | a Franceschini, Nora4 aut |
700 | 1 | a Boerwinkle, Eric4 aut |
700 | 1 | a Egan, Josephine4 aut |
700 | 1 | a Hernandez, Dena4 aut |
700 | 1 | a Reilly, Muredach4 aut |
700 | 1 | a Townsend, Raymond R.4 aut |
700 | 1 | a Lumley, Thomas4 aut |
700 | 1 | a Siscovick, David S.4 aut |
700 | 1 | a Psaty, Bruce M.4 aut |
700 | 1 | a Kestenbaum, Bryan4 aut |
700 | 1 | a Haritunians, Talin4 aut |
700 | 1 | a Bergmann, Sven4 aut |
700 | 1 | a Vollenweider, Peter4 aut |
700 | 1 | a Waeber, Gerard4 aut |
700 | 1 | a Mooser, Vincent4 aut |
700 | 1 | a Waterworth, Dawn4 aut |
700 | 1 | a Johnson, Andrew D.4 aut |
700 | 1 | a Florez, Jose C.4 aut |
700 | 1 | a Meigs, James B.4 aut |
700 | 1 | a Lu, Xiaoning4 aut |
700 | 1 | a Turner, Stephen T.4 aut |
700 | 1 | a Atkinson, Elizabeth J.4 aut |
700 | 1 | a Leak, Tennille S.4 aut |
700 | 1 | a Aasarod, Knut4 aut |
700 | 1 | a Skorpen, Frank4 aut |
700 | 1 | a Syvänen, Ann-Christineu Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:uu)anncsyva |
700 | 1 | a Illig, Thomas4 aut |
700 | 1 | a Baumert, Jens4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kraemer, Bernhard K.4 aut |
700 | 1 | a Devuyst, Olivier4 aut |
700 | 1 | a Mychaleckyj, Josyf C.4 aut |
700 | 1 | a Minelli, Cosetta4 aut |
700 | 1 | a Bakker, Stephan J. L.4 aut |
700 | 1 | a Kedenko, Lyudmyla4 aut |
700 | 1 | a Paulweber, Bernhard4 aut |
700 | 1 | a Coassin, Stefan4 aut |
700 | 1 | a Endlich, Karlhans4 aut |
700 | 1 | a Kroemer, Heyo K.4 aut |
700 | 1 | a Biffar, Reiner4 aut |
700 | 1 | a Stracke, Sylvia4 aut |
700 | 1 | a Voelzke, Henry4 aut |
700 | 1 | a Stumvol, Michael4 aut |
700 | 1 | a Maegi, Reedik4 aut |
700 | 1 | a Campbell, Harry4 aut |
700 | 1 | a Vitart, Veronique4 aut |
700 | 1 | a Hastie, Nicholas D.4 aut |
700 | 1 | a Gudnason, Vilmundur4 aut |
700 | 1 | a Kardia, Sharon L. R.4 aut |
700 | 1 | a Liu, Yongmei4 aut |
700 | 1 | a Polasek, Ozren4 aut |
700 | 1 | a Curhan, Gary4 aut |
700 | 1 | a Kronenberg, Florian4 aut |
700 | 1 | a Prokopenko, Inga4 aut |
700 | 1 | a Rudan, Igor4 aut |
700 | 1 | a Ärnlöv, Johanu Högskolan Dalarna,Uppsala universitet,Geriatrik,Medicinsk vetenskap4 aut0 (Swepub:du)jan |
700 | 1 | a Hallan, Stein4 aut |
700 | 1 | a Navis, Gerjan4 aut |
700 | 1 | a Parsa, Afshin4 aut |
700 | 1 | a Ferrucci, Luigi4 aut |
700 | 1 | a Coresh, Josef4 aut |
700 | 1 | a Shlipak, Michael G.4 aut |
700 | 1 | a Bul, Shelley B.4 aut |
700 | 1 | a Paterson, Andrew D.4 aut |
700 | 1 | a Wichmann, H. -Erich4 aut |
700 | 1 | a Wareham, Nicholas J.4 aut |
700 | 1 | a Loos, Ruth J. F.4 aut |
700 | 1 | a Rotter, Jerome I.4 aut |
700 | 1 | a Pramstaller, Peter P.4 aut |
700 | 1 | a Cupples, L. Adrienne4 aut |
700 | 1 | a Beckmann, Jacques S.4 aut |
700 | 1 | a Yang, Qiong4 aut |
700 | 1 | a Heid, Iris M.4 aut |
700 | 1 | a Rettig, Rainer4 aut |
700 | 1 | a Dreisbach, Albert W.4 aut |
700 | 1 | a Bochud, Murielle4 aut |
700 | 1 | a Fox, Caroline S.4 aut |
700 | 1 | a Kao, W. H. L.4 aut |
710 | 2 | a Karolinska Institutetb Molekylär medicin4 org |
773 | 0 | t Journal of the American Society of Nephrologyg 22:3, s. 555-570q 22:3<555-570x 1046-6673x 1533-3450 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151658 |
856 | 4 8 | u https://doi.org/10.1681/ASN.2010060598 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:122240148 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:du-5794 |
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