Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies

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Fältnamn	Indikatorer	Metadata
000		05897naa a2201033 4500
001		oai:DiVA.org:umu-112254
003		SwePub
008		151204s2015 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1122542 URI
024	7	a https://doi.org/10.3945/ajcn.115.1143062 DOI
040		a (SwePub)umu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Key, Timothy J.4 aut
245	1 0	a Carotenoids, retinol, tocopherols, and prostate cancer risk :b pooled analysis of 15 studies
264	1	b Elsevier BV,c 2015
338		a print2 rdacarrier
520		a Background: Individual studies have suggested that circulating carotenoids, retinol, or tocopherols may be associated with prostate cancer risk, but the studies have not been large enough to provide precise estimates of associations, particularly by stage and grade of disease. Objective: The objective of this study was to conduct a pooled analysis of the associations of the concentrations of 7 carotenoids, retinol, alpha-tocopherol, and gamma-tocopherol with risk of prostate cancer and to describe whether any associations differ by stage or grade of the disease or other factors. Design: Principal investigators of prospective studies provided individual participant data for prostate cancer cases and controls. Risk by study-specific fifths of each biomarker was estimated by using multivariable-adjusted conditional logistic regression in matched case-control sets. Results: Data were available for up to 11,239 cases (including 1654 advanced stage and 1741 aggressive) and 18,541 controls from 15 studies. Lycopene was not associated with overall risk of prostate cancer, but there was statistically significant heterogeneity by stage of disease, and the OR for aggressive disease for the highest compared with the lowest fifth of lycopene was 0.65 (95% CI: 0.46, 0.91; P-trend = 0.032). No other carotenoid was significantly associated with overall risk of prostate cancer or with risk of advanced-stage or aggressive disease. For retinol, the OR for the highest compared with the lowest fifth was 1.13 (95% CI: 1.04, 1.22; P-trend = 0.015). For alpha-tocopherol, the OR for the highest compared with the lowest fifth was 0.86 (95% CI: 0.78, 0.94; P-trend < 0.001), with significant heterogeneity by stage of disease; the OR for aggressive prostate cancer was 0.74 (95% CI: 0.59, 0.92; P-trend = 0.001). gamma-Tocopherol was not associated with risk. Conclusions: Overall prostate cancer risk was positively associated with retinol and inversely associated with alpha-tocopherol, and risk of aggressive prostate cancer was inversely associated with lycopene and alpha-tocopherol. Whether these associations reflect causal relations is unclear.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653		a prostate cancer
653		a carotenoids
653		a retinol
653		a tocopherols
653		a vitamin E
653		a vitamin A
653		a pooled analysis
653		a nested case-control study
653		a biomarkers
700	1	a Appleby, Paul N.4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Albanes, Demetrius4 aut
700	1	a Alberg, Anthony J.4 aut
700	1	a Barricarte, Aurelio4 aut
700	1	a Black, Amanda4 aut
700	1	a Boeing, Heiner4 aut
700	1	a Bueno-de-Mesquita, H. Bas4 aut
700	1	a Chan, June M.4 aut
700	1	a Chen, Chu4 aut
700	1	a Cook, Michael B.4 aut
700	1	a Donovan, Jenny L.4 aut
700	1	a Galan, Pilar4 aut
700	1	a Gilbert, Rebecca4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Giovannucci, Edward4 aut
700	1	a Goodman, Gary E.4 aut
700	1	a Goodman, Phyllis J.4 aut
700	1	a Gunter, Marc J.4 aut
700	1	a Hamdy, Freddie C.4 aut
700	1	a Heliovaara, Markku4 aut
700	1	a Helzlsouer, Kathy J.4 aut
700	1	a Henderson, Brian E.4 aut
700	1	a Hercberg, Serge4 aut
700	1	a Hoffman-Bolton, Judy4 aut
700	1	a Hoover, Robert N.4 aut
700	1	a Johansson, Mattiasu Umeå universitet,Enheten för biobanksforskning,International Agency for Research on Cancer, Lyon, France4 aut0 (Swepub:umu)masmas97
700	1	a Khaw, Kay-Tee4 aut
700	1	a King, Irena B.4 aut
700	1	a Knekt, Paul4 aut
700	1	a Kolonel, Laurence N.4 aut
700	1	a Le Marchand, Loic4 aut
700	1	a Mannisto, Satu4 aut
700	1	a Martin, Richard M.4 aut
700	1	a Meyer, Haakon E.4 aut
700	1	a Mondul, Alison M.4 aut
700	1	a Moy, Kristin A.4 aut
700	1	a Neal, David E.4 aut
700	1	a Neuhouser, Marian L.4 aut
700	1	a Palli, Domenico4 aut
700	1	a Platz, Elizabeth A.4 aut
700	1	a Pouchieu, Camille4 aut
700	1	a Rissanen, Harri4 aut
700	1	a Schenk, Jeannette M.4 aut
700	1	a Severi, Gianluca4 aut
700	1	a Stampfer, Meir J.4 aut
700	1	a Tjonneland, Anne4 aut
700	1	a Touvier, Mathilde4 aut
700	1	a Trichopoulou, Antonia4 aut
700	1	a Weinstein, Stephanie J.4 aut
700	1	a Ziegler, Regina G.4 aut
700	1	a Zhou, Cindy Ke4 aut
700	1	a Allen, Naomi E.4 aut
710	2	a Umeå universitetb Enheten för biobanksforskning4 org
773	0	t American Journal of Clinical Nutritiond : Elsevier BVg 102:5, s. 1142-1157q 102:5<1142-1157x 0002-9165x 1938-3207
856	4	u https://academic.oup.com/ajcn/article-pdf/102/5/1142/23757671/ajcn114306.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-112254
856	4 8	u https://doi.org/10.3945/ajcn.115.114306

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Av författaren/redakt...: Key, Timothy J.; Appleby, Paul N.; Travis, Ruth C.; Albanes, Demetri ...; Alberg, Anthony ...; Barricarte, Aure ...; visa fler...; Black, Amanda; Boeing, Heiner; Bueno-de-Mesquit ...; Chan, June M.; Chen, Chu; Cook, Michael B.; Donovan, Jenny L ...; Galan, Pilar; Gilbert, Rebecca; Giles, Graham G.; Giovannucci, Edw ...; Goodman, Gary E.; Goodman, Phyllis ...; Gunter, Marc J.; Hamdy, Freddie C ...; Heliovaara, Mark ...; Helzlsouer, Kath ...; Henderson, Brian ...; Hercberg, Serge; Hoffman-Bolton, ...; Hoover, Robert N ...; Johansson, Matti ...; Khaw, Kay-Tee; King, Irena B.; Knekt, Paul; Kolonel, Laurenc ...; Le Marchand, Loi ...; Mannisto, Satu; Martin, Richard ...; Meyer, Haakon E.; Mondul, Alison M ...; Moy, Kristin A.; Neal, David E.; Neuhouser, Maria ...; Palli, Domenico; Platz, Elizabeth ...; Pouchieu, Camill ...; Rissanen, Harri; Schenk, Jeannett ...; Severi, Gianluca; Stampfer, Meir J ...; Tjonneland, Anne; Touvier, Mathild ...; Trichopoulou, An ...; Weinstein, Steph ...; Ziegler, Regina ...; Zhou, Cindy Ke; Allen, Naomi E.; visa färre...

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