Association Between Statin Use and Inflammatory Bowel Diseases: Results from a Swedish, Nationwide, Population-based Case-control Study

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: (WFRF:(Khalili Hamed)) > (2021) > Association Between...

Association Between Statin Use and Inflammatory Bowel Diseases : Results from a Swedish, Nationwide, Population-based Case-control Study

Lochhead, Paul (author): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA

Khalili, Hamed (author): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA

Sachs, Michael C. (author): Karolinska Institutet

Chan, Andrew T. (author): Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston MA, USA; Division of Gastroenterology, Massachusetts General Hospital, Boston MA, USA

Olén, Ola (author): Karolinska Institutet

Ludvigsson, Jonas F., 1969- (author): Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden

show less...

(creator_code:org_t)

2020-11-20
2021
English.
In: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 15:5, s. 757-765

Related links:: https://doi.org/10.1...; show more...; https://academic.oup...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: In addition to their potent lipid-lowering action, statins may modulate inflammation. However, data on statin use and the risk of inflammatory bowel diseases [IBD] have been inconsistent.Methods: We searched the Nationwide Swedish Patient Register [inpatient and non-primary outpatient care] to identify adults diagnosed with Crohn's disease [CD, n=7637] or ulcerative colitis [UC, n=15 652] from 2006 to 2014. Each case was matched to 10 general population controls [n=232 890]. Data on dispensed statin prescriptions were extracted from the Prescribed Drug Register. Conditional logistic regression models estimated odds ratios [ORs] for risk of IBD according to statin exposure while controlling for potential confounders, including indications for statin therapy.Results: In multivariable adjusted models, compared with no statin use, any statin use was associated with a lower risk of CD (OR=0.71; 95% confidence interval [CI], 0.63-0.79), but not UC [OR=1.03; 95% CI, 0.96-1.11]. The lowest OR for CD was seen for current statin use [OR=0.67; 95% CI, 0.60-0.75]. For CD, the lowest category of cumulative statin dose [31-325 defined daily dose, DDD] was associated with an OR of 0.73 [95% CI, 0.61-0.88] and the highest category [>1500 DDD] with an OR of 0.66 [95% CI, 0.55-0.80], p(trend)=0.10. For UC, the lowest and highest dose categories yielded ORs of 1.12 [95% CI, 1.00-1.25] and 0.99 [95% CI, 0.88-1.13], respectively, p(trend) = 0.13.Conclusions: Statin use was associated with a lower risk of CD, but not of UC. The association with CD risk appeared strongest for current statin use. Our findings suggest that statin use may influence the development of CD.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Keyword

Crohn's disease
ulcerative colitis
inflammatory bowel diseases
statin
registry
prescription
adult
medication
drug
pharmacoepidemiology
Sweden

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

Journal of Crohn's & Colitis (Search for host publication in LIBRIS)

To the university's database

Find more in SwePub

By the author/editor: Lochhead, Paul; Khalili, Hamed; Sachs, Michael C ...; Chan, Andrew T.; Olén, Ola; Ludvigsson, Jona ...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Gastroenterology ...

Articles in the publication: Journal of Crohn ...

By the university: Örebro University; Karolinska Institutet

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se