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Sökning: (WFRF:(Lund E Eiliv)) > Haplotypes of the e...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004749naa a2200793 4500
001oai:lup.lub.lu.se:66b2fb5f-cc51-4e91-88c2-221610dcc797
003SwePub
008160401s2008 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/11438472 URI
0247 a https://doi.org/10.1002/ijc.231272 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Cox, David G4 aut
2451 0a Haplotypes of the estrogen receptor beta gene and breast cancer risk
264 c 2007-10-12
264 1b Wiley,c 2008
520 a Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the steroid hormone synthesis, metabolism and signaling pathways. Estrogen receptors are the first step along the path of signaling cell growth and development upon stimulation with estrogens. The National Cancer Institute Breast and Prostate Cancer Cohort Consortium has systematically selected haplotype tagging SNPs in genes along the steroid hormone synthesis, metabolism and binding pathways, including the estrogen receptor beta (ESR2) gene. Four htSNPs tag the 6 major (>5% frequency) haplotypes of the ESR2 gene. These polymorphisms have been genotyped in 5,789 breast cancer cases and 7,761 controls nested within the American Cancer Society Cancer Prevention Study II, European Prospective Investigation into Cancer and Nutrition, Multiethnic Cohort, Nurses' Health Study and Women's Health Study cohorts. None of the SNPs were independently associated with breast cancer risk. One haplotype of the ESR2 gene was associated with breast cancer risk before correction for multiple testing (OR 1.17, 95% CI 1.07-1.28, p = 0.0007). This haplotype remained associated with breast cancer risk after adjustment for multiple testing using a permutation procedure. There was no statistically significant heterogeneity in SNP or haplotype odds ratios across cohorts. These data suggest that inherited variants in ESR2 (while possibly conferring a small increased risk of breast cancer) are not associated with appreciable (OR > 1.2) changes in breast cancer risk among Caucasian women.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
653 a risk
653 a haplotype
653 a polymorphism
653 a breast cancer
653 a estrogen receptor beta
7001 a Bretsky, Philip4 aut
7001 a Kraft, Peter4 aut
7001 a Pharoah, Paul4 aut
7001 a Albanes, Demetrius4 aut
7001 a Altshuler, David4 aut
7001 a Amiano, Pilar4 aut
7001 a Berglund, Göranu Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)medf-gbe
7001 a Boeing, Heiner4 aut
7001 a Buring, Julie4 aut
7001 a Burtt, Noel4 aut
7001 a Calle, Eugenia E4 aut
7001 a Canzian, Federico4 aut
7001 a Chanock, Stephen4 aut
7001 a Clavel-Chapelon, Françoise4 aut
7001 a Colditz, Graham A4 aut
7001 a Spencer Feigelson, Heather4 aut
7001 a Haiman, Christopher A4 aut
7001 a Hankinson, Susan E4 aut
7001 a Hirschhorn, Joel4 aut
7001 a Henderson, Brian E4 aut
7001 a Hoover, Robert4 aut
7001 a Hunter, David J4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Kolonel, Laurence4 aut
7001 a LeMarchand, Loic4 aut
7001 a Lund, Eiliv4 aut
7001 a Palli, Domenico4 aut
7001 a Peeters, Petra H M4 aut
7001 a Pike, Malcolm C4 aut
7001 a Riboli, Elio4 aut
7001 a Stram, Daniel O4 aut
7001 a Thun, Michael4 aut
7001 a Tjonneland, Anne4 aut
7001 a Travis, Ruth C4 aut
7001 a Trichopoulos, Dimitrios4 aut
7001 a Yeager, Meredith4 aut
7102 a Internmedicin - epidemiologib Forskargrupper vid Lunds universitet4 org
7730 t International Journal of Cancerd : Wileyg 122:2, s. 387-392q 122:2<387-392x 0020-7136
8564 u http://dx.doi.org/10.1002/ijc.23127y FULLTEXT
8564 u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.23127
8564 8u https://lup.lub.lu.se/record/1143847
8564 8u https://doi.org/10.1002/ijc.23127

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