(WFRF:(MacInnis Robert J))
Sökning: (WFRF:(MacInnis Robert J)) > (2020-2024) > Genome-wide interac...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 17440naa a2201573 4500 | |
| 001 | oai:DiVA.org:uu-474883 | |
| 003 | SwePub | |
| 008 | 220525s2022 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:9a80b98c-5fc0-49b6-bf25-f9df5f497ccd | |
| 009 | oai:prod.swepub.kib.ki.se:149482878 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4748832 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-022-10121-22 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/9a80b98c-5fc0-49b6-bf25-f9df5f497ccd2 URI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1494828782 URI |
| 040 | a (SwePub)uud (SwePub)lud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Wang, Xiaoliangu Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.,University of Washington, Seattle,Fred Hutchinson Cancer Research Center4 aut |
| 245 | 1 0 | a Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women |
| 264 | c 2022-04-13 | |
| 264 | 1 | b Springer Nature,c 2022 |
| 338 | a electronic2 rdacarrier | |
| 520 | a Use of menopausal hormone therapy (MHT) is associated with increased risk for breast cancer. However, the relevant mechanisms and its interaction with genetic variants are not fully understood. We conducted a genome-wide interaction analysis between MHT use and genetic variants for breast cancer risk in 27,585 cases and 34,785 controls from 26 observational studies. All women were post-menopausal and of European ancestry. Multivariable logistic regression models were used to test for multiplicative interactions between genetic variants and current MHT use. We considered interaction p-values < 5 x 10(-8) as genome-wide significant, and p-values < 1 x 10(-5) as suggestive. Linkage disequilibrium (LD)-based clumping was performed to identify independent candidate variants. None of the 9.7 million genetic variants tested for interactions with MHT use reached genome-wide significance. Only 213 variants, representing 18 independent loci, had p-values < 1 x 10(5). The strongest evidence was found for rs4674019 (p-value = 2.27 x 10(-7)), which showed genome-wide significant interaction (p-value = 3.8 x 10(-8)) with current MHT use when analysis was restricted to population-based studies only. Limiting the analyses to combined estrogen-progesterone MHT use only or to estrogen receptor (ER) positive cases did not identify any genome-wide significant evidence of interactions. In this large genome-wide SNP-MHT interaction study of breast cancer, we found no strong support for common genetic variants modifying the effect of MHT on breast cancer risk. These results suggest that common genetic variation has limited impact on the observed MHT-breast cancer risk association. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a adverse event | |
| 653 | a breast | |
| 653 | a breast tumor | |
| 653 | a estrogen therapy | |
| 653 | a female | |
| 653 | a genetics | |
| 653 | a hormone substitution | |
| 653 | a human | |
| 653 | a male | |
| 653 | a menopause | |
| 653 | a risk factor | |
| 653 | a Breast | |
| 653 | a Breast Neoplasms | |
| 653 | a Estrogen Replacement Therapy | |
| 653 | a Female | |
| 653 | a Hormone Replacement Therapy | |
| 653 | a Humans | |
| 653 | a Male | |
| 653 | a Menopause | |
| 653 | a Risk Factors | |
| 700 | 1 | a Kapoor, Pooja Middhau German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Heidelberg Univ, Fac Med, Heidelberg, Germany.4 aut |
| 700 | 1 | a Auer, Paul L.u Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Canc Ctr, Milwaukee, WI 53226 USA.4 aut |
| 700 | 1 | a Dennis, Joeu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.4 aut |
| 700 | 1 | a Dunning, Alison M.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut |
| 700 | 1 | a Wang, Qinu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.4 aut |
| 700 | 1 | a Lush, Michaelu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.4 aut |
| 700 | 1 | a Michailidou, Kyriakiu Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Cyprus Inst Neurol & Genet, Biostat Unit, Nicosia, Cyprus.;Cyprus Sch Mol Med, Cyprus Inst Neurol & Genet, Nicosia, Cyprus.4 aut |
| 700 | 1 | a Bolla, Manjeet K.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.4 aut |
| 700 | 1 | a Aronson, Kristan J.u Queens Univ, Canc Res Inst, Dept Publ Hlth Sci, Kingston, ON, Canada.4 aut |
| 700 | 1 | a Augustinsson, A.u Karolinska Institutet,Lund University,Lunds universitet,Vård i högteknologisk miljö,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,Care in high technological environments,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Biomarkers and epidemiology,Department of Clinical Sciences, Lund4 aut0 (Swepub:lu)med-aea |
| 700 | 1 | a Brooks-Wilson, Angelau BC Canc Agcy, Genome Sci Ctr, Vancouver, BC, Canada.;Simon Fraser Univ, Dept Biomed Physiol & Kinesiol, Burnaby, BC, Canada.4 aut |
| 700 | 1 | a Lee, Derrick G.u BC Canc, Canc Control Res, Vancouver, BC, Canada.;St Francis Xavier Univ, Dept Math & Stat, Antigonish, NS, Canada.4 aut |
| 700 | 1 | a Guenel, Pascalu Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, Villejuif, France.4 aut |
| 700 | 1 | a Truong, Thereseu Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM, Team Exposome & Hered, Villejuif, France.4 aut |
| 700 | 1 | a Mulot, Claireu Univ Paris Sorbonne, INSERM UMR S1147, Paris, France.4 aut |
| 700 | 1 | a Teras, Lauren R.u Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA.4 aut |
| 700 | 1 | a Patel, Alpa, Vu Amer Canc Soc, Dept Populat Sci, Atlanta, GA 30329 USA.4 aut |
| 700 | 1 | a Dossus, Laureu Int Agcy Res Canc IARC WHO, Nutr & Metab Branch, Lyon, France.4 aut |
| 700 | 1 | a Kaaks, Rudolfu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut |
| 700 | 1 | a Hoppe, Reineru Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tybingen, Tybingen, Germany.4 aut |
| 700 | 1 | a Bruening, Thomasu Inst Ruhr Univ Bochum IPA, Inst Prevent & Occupat Med, German Social Accid Insurance, Bochum, Germany.4 aut |
| 700 | 1 | a Hamann, Uteu German Canc Res Ctr, Mol Genet Breast Canc, Heidelberg, Germany.4 aut |
| 700 | 1 | a Czene, Kamilau Karolinska Institutet4 aut |
| 700 | 1 | a Gabrielson, Marikeu Karolinska Institutet4 aut |
| 700 | 1 | a Hall, Peru Karolinska Institutet4 aut |
| 700 | 1 | a Eriksson, Mikaelu Karolinska Institutet4 aut |
| 700 | 1 | a Jung, Audreyu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.4 aut |
| 700 | 1 | a Becher, Heikou Univ Med Ctr Hamburg Eppendorf, Inst Med Biometry & Epidemiol, Hamburg, Germany.4 aut |
| 700 | 1 | a Couch, Fergus J.u Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA.4 aut |
| 700 | 1 | a Larson, Nicole L.u Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.4 aut |
| 700 | 1 | a Olson, Janet E.u Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.4 aut |
| 700 | 1 | a Ruddy, Kathryn J.u Mayo Clin, Dept Oncol, Rochester, MN USA.4 aut |
| 700 | 1 | a Giles, Graham G.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut |
| 700 | 1 | a MacInnis, Robert J.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Southey, Melissa C.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.;Univ Melbourne, Dept Clin Pathol, Melbourne, Vic, Australia.4 aut |
| 700 | 1 | a Le Marchand, Loicu Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI USA.4 aut |
| 700 | 1 | a Wilkens, Lynne R.u Univ Hawaii Canc Ctr, Canc Epidemiol Program, Honolulu, HI USA.4 aut |
| 700 | 1 | a Haiman, Christopher A.u Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.4 aut |
| 700 | 1 | a Olsson, H.u Lund University,Lunds universitet,Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol |
| 700 | 1 | a Augustinsson, Annelieu Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden.4 aut |
| 700 | 1 | a Krüger, U.u Lund University,Lunds universitet,Lund Univ, Dept Canc Epidemiol, Clin Sci, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-ukr |
| 700 | 1 | a Wagner, P.u Lund University,Lunds universitet,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)med-pwn |
| 700 | 1 | a Scott, Christopheru Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA.4 aut |
| 700 | 1 | a Winham, Stacey J.u Mayo Clin, Div Biomed Stat & Informat, Dept Hlth Sci Res, Rochester, MN USA.4 aut |
| 700 | 1 | a Vachon, Celine M.u Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA.;Univ North Carolina Chapel Hill, Dept Genet, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut |
| 700 | 1 | a Perou, Charles M.u Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA.;Univ North Carolina Chapel Hill, Dept Genet, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut |
| 700 | 1 | a Olshan, Andrew F.u Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Epidemiol, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut |
| 700 | 1 | a Troester, Melissa A.u Univ North Carolina Chapel Hill, Gillings Sch Global Publ Hlth, Dept Epidemiol, UNC Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA.4 aut |
| 700 | 1 | a Hunter, David J.u Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.4 aut |
| 700 | 1 | a Eliassen, Heather A.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Tamimi, Rulla M.u Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Weill Cornell Med, Dept Populat Hlth Sci, New York, NY USA.4 aut |
| 700 | 1 | a Brantley, Kristenu Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA.4 aut |
| 700 | 1 | a Andrulis, Irene L.u Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst Mt Sinai Hosp, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.4 aut |
| 700 | 1 | a Figueroa, Jonineu Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland.;Univ Edinburgh, Canc Res UK Edinburgh Ctr, Edinburgh, Midlothian, Scotland.;NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Chanock, Stephen J.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Ahearn, Thomas U.u NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, NIH, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Evans, Gareth D.u Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth5, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, North West Genom Lab Hub,St Marys Hosp, Manchester, Lancs, England.4 aut |
| 700 | 1 | a Newman, William G.u Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth5, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, North West Genom Lab Hub,St Marys Hosp, Manchester, Lancs, England.4 aut |
| 700 | 1 | a VanVeen, Elke M.u Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth5, Sch Biol Sci,Div Evolut & Genom Sci, Manchester, Lancs, England.;Manchester Univ NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, North West Genom Lab Hub,St Marys Hosp, Manchester, Lancs, England.4 aut |
| 700 | 1 | a Howell, Anthonyu Univ Manchester, Div Canc Sci, Manchester, Lancs, England.4 aut |
| 700 | 1 | a Wolk, Alicjau Uppsala universitet,Medicinsk epidemiologi,Karolinska Inst, Inst Environm Med, Stockholm, Sweden4 aut0 (Swepub:uu)alwol516 |
| 700 | 1 | a Hakansson, Niclasu Karolinska Institutet4 aut |
| 700 | 1 | a Ziogas, Argyriosu Univ Calif Irvine, Dept Med, Genet Epidemiol Res Inst, Irvine, CA 92717 USA.4 aut |
| 700 | 1 | a Jones, Michael E.u Inst Canc Res, Div Genet & Epidemiol, London, England.4 aut |
| 700 | 1 | a Orr, Nicku Queens Univ Belfast, Ctr Canc Res & Cell Biol, Belfast, North Ireland.4 aut |
| 700 | 1 | a Schoemaker, Minouk J.u Inst Canc Res, Div Genet & Epidemiol, London, England.4 aut |
| 700 | 1 | a Swerdlow, Anthony J.u Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England.4 aut |
| 700 | 1 | a Kitahara, Cari M.u NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Linet, Marthau NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.4 aut |
| 700 | 1 | a Prentice, Ross L.u Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.4 aut |
| 700 | 1 | a Easton, Douglas F.u Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.4 aut |
| 700 | 1 | a Milne, Roger L.u Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Melbourne Sch Populat & Global Hlth, Melbourne, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.4 aut |
| 700 | 1 | a Kraft, Peteru Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.4 aut |
| 700 | 1 | a Chang-Claude, Jennyu German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Canc Ctr Hamburg UCCH, Univ Med Ctr Hamburg Eppendorf, Canc Epidemiol Grp, Hamburg, Germany.4 aut |
| 700 | 1 | a Lindstrom, Sarau Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.,University of Washington, Seattle,Fred Hutchinson Cancer Research Center4 aut |
| 710 | 2 | a Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, 1124 Columbia St, Seattle, WA 98104 USA.b University of Washington, Seattle4 org |
| 710 | 2 | a et al. |
| 773 | 0 | t Scientific Reportsd : Springer Natureg 12:1q 12:1x 2045-2322 |
| 856 | 4 | u https://doi.org/10.1038/s41598-022-10121-2y Fulltext |
| 856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1660974/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u http://dx.doi.org/10.1038/s41598-022-10121-2x freey FULLTEXT |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-474883 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-022-10121-2 |
| 856 | 4 8 | u https://lup.lub.lu.se/record/9a80b98c-5fc0-49b6-bf25-f9df5f497ccd |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:149482878 |
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