SwePub
Sök i LIBRIS databas

  Extended search

(WFRF:(McKay James)) pers:(Brennan Paul)
 

Search: (WFRF:(McKay James)) pers:(Brennan Paul) > (2020-2024) > Identifying therape...

Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers

Smith-Byrne, Karl (author)
Univ Oxford, Canc Epidemiol Unit, Oxford Populat Hlth, Oxford, England.
Hedman, Åsa (author)
Pfizer Worldwide Res Dev & Med, External Sci & Innovat, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.
Dimitriou, Marios (author)
Karolinska Institutet,Pfizer Worldwide Res Dev & Med, External Sci & Innovat, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.
show more...
Desai, Trishna (author)
Univ Oxford, Canc Epidemiol Unit, Oxford Populat Hlth, Oxford, England.
Sokolov, Aleksandr V. (author)
Uppsala universitet,Funktionell farmakologi och neurovetenskap
Schiöth, Helgi B. (author)
Uppsala universitet,Funktionell farmakologi och neurovetenskap
Koprulu, Mine (author)
Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
Pietzner, Maik (author)
Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Charite Univ Medizin Berlin, Berlin Inst Hlth, Computat Med, Berlin, Germany.;Queen Mary Univ London, Precis Healthcare Inst, London, England.
Langenberg, Claudia (author)
Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.;Charite Univ Medizin Berlin, Berlin Inst Hlth, Computat Med, Berlin, Germany.;Queen Mary Univ London, Precis Healthcare Inst, London, England.
Atkins, Joshua (author)
Univ Oxford, Canc Epidemiol Unit, Oxford Populat Hlth, Oxford, England.
Cortez Penha, Ricardo (author)
Int Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France.
McKay, James (author)
Int Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France.
Brennan, Paul (author)
Int Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France.
Zhou, Sirui (author)
McGill Univ, Dept Human Genet, Montreal, PQ, Canada.
Richards, Brent J. (author)
McGill Univ, Dept Med Endocrinol, Montreal, PQ, Canada.;McGill Univ, Dept Human Genet, Montreal, PQ, Canada.;McGill Univ, Dept Epidemiol & Biostat, Montreal, PQ, Canada.
Yarmolinsky, James (author)
Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England.
Martin, Richard M. (author)
Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, England.;Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, England.;Univ Bristol, Hosp Bristol & Weston NHS Fdn Trust, NIHR Bristol Biomed Res Ctr, Bristol, England.
Borlido, Joana (author)
Pfizer Inc, Canc Immunol Discovery, Pfizer Worldwide Res & Dev Med, San Diego, CA USA.
Mu, Xinmeng J. (author)
Pfizer Inc, Oncol Res Unit, Pfizer Worldwide Res & Dev Med, San Diego, CA USA.
Butterworth, Adam (author)
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Shen, Xia (author)
Univ Edinburgh, Usher Inst, MRC Human Genet Unit, Edinburgh, Scotland.
Wilson, Jim (author)
Univ Edinburgh, Usher Inst, MRC Human Genet Unit, Edinburgh, Scotland.
Assimes, Themistocles L. (author)
Stanford Univ, Div Cardiovasc Med, Stanford, CA USA.;Stanford Univ, Cardiovasc Inst, Sch Med, Stanford, CA USA.
Hung, Rayjean J. (author)
Sinai Hlth Syst, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Hlth Res, Toronto, ON, Canada.;Univ Toronto, Toronto, ON, Canada.
Amos, Christopher (author)
Baylor Med Coll, Inst Clin & Translat Res, Dept Med, Epidemiol Sect, Houston, TX USA.
Purdue, Mark (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Rothman, Nathaniel (author)
NCI, Div Canc Epidemiol & Genet, Occupat & Environm Epidemiol Branch, Rockville, MD USA.
Chanock, Stephen (author)
NCI, Div Canc Epidemiol & Genet, Rockville, MD USA.
Travis, Ruth C. (author)
Univ Oxford, Canc Epidemiol Unit, Oxford Populat Hlth, Oxford, England.
Johansson, Mattias (author)
Int Agcy Res Canc IARC WHO, Genom Epidemiol Branch, Lyon, France.
Mälarstig, Anders (author)
Pfizer Worldwide Res Dev & Med, External Sci & Innovat, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden.
show less...
Univ Oxford, Canc Epidemiol Unit, Oxford Populat Hlth, Oxford, England Pfizer Worldwide Res Dev & Med, External Sci & Innovat, Stockholm, Sweden.;Karolinska Inst, Dept Med, Stockholm, Sweden. (creator_code:org_t)
Springer Nature, 2024
2024
English.
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
Related links:
https://doi.org/10.1...
show more...
https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovary, pancreas, kidney, and malignant non-melanoma) using cis protein Mendelian randomisation and colocalization. We conduct additional analyses to identify adverse side-effects of altering risk proteins and map cancer risk proteins to drug targets. Here we find 40 proteins associated with common cancers, such as PLAUR and risk of breast cancer [odds ratio per standard deviation increment: 2.27, 1.88-2.74], and with high-mortality cancers, such as CTRB1 and pancreatic cancer [0.79, 0.73-0.85]. We also identify potential adverse effects of protein-altering interventions to reduce cancer risk, such as hypertension. Additionally, we report 18 proteins associated with cancer risk that map to existing drugs and 15 that are not currently under clinical investigation. In sum, we identify protein-cancer links that improve our understanding of cancer aetiology. We also demonstrate that the wider consequence of any protein-altering intervention on well-being and morbidity is required to interpret any utility of proteins as potential future targets for therapeutic prevention.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view