CRP is associated with lung function decline in men but not women: a prospective study

Olafsdottir, Inga SifUppsala universitet,Institutionen för medicinska vetenskaper,Lungmedicin och allergologi (author)

CRP is associated with lung function decline in men but not women : a prospective study

Systemic inflammation is associated with impaired lung function. Studies, most cross-sectional, report a stronger association between systemic inflammation and lung function impairment in men than women. The aim was to evaluate gender differences in the longitudinal association between systemic inflammation and lung function.We used data from randomly chosen residents of Reykjavík, born 1940–54, who were investigated in three stages: Baseline (1973–75; 1983–85) and follow-up (2001–03). The participants (n = 1049, 574 women) had a mean age of 28 ± 6 years at baseline and mean follow-up time of 27 ± 4 years. At each stage lung function (FEV1 and FVC) and C-reactive protein (CRP) were evaluated.Change in FEV1 (p = 0.04) and FVC (p = 0.01) was associated with baseline CRP in men but not in women. In the multiple variable analysis, CRP at baseline was associated with a decline in FEV1 (−3.1 mL/year, 95% CI: −5.1, −0.99) and FVC (−2.5 mL/year, 95% CI: −4.4, −0.65) in men but not in women. Similarly during follow-up, change in CRP, standardised to 1SD, was associated with a decline in FEV1 (−0.19 mL/year, 95% CI: −0.30, −0.07) and FVC (−0.11 mL/year, 95% CI: −0.22, −0.01)) in men but not in women.This prospective study confirms a stronger association between systemic inflammation and lung function decline in men than in women. This may indicate a gender difference in the mechanisms of lung function decline.

Gíslason, ThórarinnFaculty of Medicine, University of Iceland; Department of Allergy, Respiratory Medicine & Sleep, Landspitali University Hospital (author)
Gudnason, VilmundurFaculty of Medicine, University of Iceland; Icelandic Heart Association (author)
Benediktsdóttir, BryndísFaculty of Medicine, University of Iceland; Department of Allergy, Respiratory Medicine & Sleep, Landspitali University Hospital (author)
Ólafsson, ÍsleifurDepartment of Clinical Biochemistry, Landspitali University Hospital, Iceland (author)
Aspelund, ThorFaculty of Medicine, University of Iceland; Icelandic Heart Association (author)
Thjódleifsson, BjarniFaculty of Medicine, University of Iceland, Iceland; Department. of Gastroenterology, Landspitali University Hospital, Iceland (author)
Janson, ChristerUppsala universitet,Lungmedicin och allergologi(Swepub:uu)chrisjn (author)
Uppsala universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

By the author/editor: Olafsdottir, Ing ...; Gíslason, Thórar ...; Gudnason, Vilmun ...; Benediktsdóttir, ...; Ólafsson, Ísleif ...; Aspelund, Thor; show more...; Thjódleifsson, B ...; Janson, Christer; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Respiratory Medi ...

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