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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004153naa a2200457 4500
001oai:DiVA.org:uu-140855
003SwePub
008110110s2010 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1408552 URI
0247 a https://doi.org/10.1016/j.sleep.2010.08.0062 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Benediktsdottir, Bryndis4 aut
2451 0a Prevalence of restless legs syndrome among adults in Iceland and Sweden :b Lung function, comorbidity, ferritin, biomarkers and quality of life
264 1b Elsevier BV,c 2010
338 a print2 rdacarrier
520 a Objective: This study investigates the prevalence and the association between restless legs syndrome (RLS) and a large variety of health variables in two well-characterized random samples from the general population in Reykjavik, Iceland, and Uppsala, Sweden. Methods: Using the national registries of inhabitants, a random sample from adults aged 40 and over living in Reykjavík, Iceland (n= 939), and Uppsala, Sweden (n= 998), were invited to participate in a study on the prevalence of COPD (response rate 81.1% and 62.2%). In addition, the participants were asked to answer the following questionnaires: International RLS Rating Scale, Short Form-12, the Epworth Sleepiness Scale, and questions about sleep, gastroeosophageal reflux, diabetes and hypertension, as well as pharmacological treatment. Interleukin-6 (IL-6), C-reactive protein (CRP) and ferritin were measured in serum. Results: RLS was more commonly reported in Reykjavik (18.3%) than in Uppsala (11.5%). Icelandic women reported RLS almost twice as often as Swedish women (24.4 vs. 13.9% p= 0.001), but there was no difference in prevalence of RLS between Icelandic and Swedish men. RLS was strongly associated with sleep disturbances and excessive daytime sleepiness. Subjects with RLS were more likely to be ex- and current smokers than subjects without RLS (p< 0.001). Respiratory symptoms and airway obstruction were more prevalent among those reporting RLS and they also estimated their physical quality of life lower than those without RLS (p< 0.001). RLS was not associated with symptoms of the metabolic syndrome like hypertension, obesity, markers of systemic inflammation (IL-6 and CRP) or cardiovascular diseases. Ferritin levels were significantly lower in RLS participants (p= 0.0002), but not (p= 0.07) after adjustment for center, age, sex and smoking history. Conclusion: Restless legs syndrome was twice as common among Icelandic women compared to Swedish women. No such difference was seen for men. RLS was strongly associated with smoking and respiratory symptoms, decreased lung function, sleep disturbances, excessive daytime sleepiness, and physical aspects of life quality. RLS was not associated with markers of the metabolic syndrome like hypertension, obesity, cardiovascular diseases or biomarkers of systemic inflammation.
653 a CRP
653 a Epidemiology
653 a Ferritin
653 a Hypertension
653 a IL-6
653 a Lung function
653 a Quality of life
653 a Restless legs syndrome
653 a MEDICINE
653 a MEDICIN
7001 a Janson, Christeru Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)chrisjn
7001 a Lindberg, Evau Uppsala universitet,Lungmedicin och allergologi4 aut0 (Swepub:uu)evalb
7001 a Arnardóttir, Erna Sifu Uppsala universitet,Lungmedicin och allergologi,Institutionen för neurovetenskap4 aut0 (Swepub:uu)haarn677
7001 a Olafsson, Isleifur4 aut
7001 a Cook, Elizabeth4 aut
7001 a Thorarinsdottir, Elin Helga4 aut
7001 a Gislason, Thorarinn4 aut
7102 a Uppsala universitetb Lungmedicin och allergologi4 org
7730 t Sleep Medicined : Elsevier BVg 11:10, s. 1043-1048q 11:10<1043-1048x 1389-9457x 1878-5506
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-140855
8564 8u https://doi.org/10.1016/j.sleep.2010.08.006

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