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19p13.1 is a triple...
19p13.1 is a triple negative-specific breast cancer susceptibility locus
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Stevens, Kristen N (author)
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Fredericksen, Zachary (author)
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Vachon, Celine M (author)
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show more...
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Wang, Xianshu (author)
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- Margolin, Sara (author)
- Karolinska Institutet
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- Lindblom, Annika (author)
- Karolinska Institutet
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Nevanlinna, Heli (author)
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Greco, Dario (author)
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Aittomäki, Kristiina (author)
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- Blomqvist, Carl (author)
- Uppsala universitet,Enheten för onkologi
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Chang-Claude, Jenny (author)
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Vrieling, Alina (author)
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Flesch-Janys, Dieter (author)
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Sinn, Hans-Peter (author)
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Wang-Gohrke, Shan (author)
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Nickels, Stefan (author)
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Brauch, Hiltrud (author)
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Ko, Yon-Dschun (author)
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Fischer, Hans-Peter (author)
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Network, The Genica (author)
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Schmutzler, Rita K (author)
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Meindl, Alfons (author)
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Bartram, Claus R (author)
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Schott, Sarah (author)
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Engel, Christoph (author)
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Godwin, Andrew K (author)
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Weaver, Joellen (author)
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Pathak, Harsh B (author)
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Sharma, Priyanka (author)
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Brenner, Hermann (author)
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Muller, Heiko (author)
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Arndt, Volker (author)
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Stegmaier, Christa (author)
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Miron, Penelope (author)
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Yannoukakos, Drakoulis (author)
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Stavropoulou, Alexandra (author)
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Fountzilas, George (author)
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Gogas, Helen J (author)
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Swann, Ruth (author)
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Dwek, Miriam (author)
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Perkins, Katherine Anne (author)
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Milne, Roger L (author)
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Benítez, Javier (author)
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Zamora, M Pilar (author)
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Ignacio Arias Pérez, José (author)
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Bojesen, Stig E (author)
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Nielsen, Sune F (author)
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Nordestgaard, Borge G (author)
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Flyger, Henrik (author)
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Guénel, Pascal (author)
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Truong, Thérèse (author)
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Menegaux, Florence (author)
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Cordina-Duverger, Emilie (author)
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Burwinkel, Barbara (author)
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Marmé, Frederick (author)
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Schneeweiss, Andreas (author)
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Sohn, Christof (author)
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Sawyer, Elinor (author)
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Tomlinson, Ian (author)
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Kerin, Michael J (author)
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Peto, Julian (author)
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Johnson, Nichola (author)
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Fletcher, Olivia (author)
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Dos Santos Silva, Isabel (author)
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Fasching, Peter A (author)
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Beckmann, Matthias W (author)
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Hartmann, Arndt (author)
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Ekici, Arif B (author)
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Lophatananon, Artitaya (author)
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Muir, Kenneth (author)
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- Puttawibul, Puttisak (author)
- Karolinska Institutet
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Wiangnon, Surapon (author)
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Schmidt, Marjanka K (author)
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Broeks, Annegien (author)
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Braaf, Linde M (author)
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Rosenberg, Efraim H (author)
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Hopper, John L (author)
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Apicella, Carmel (author)
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Park, Daniel J (author)
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Southey, Melissa C (author)
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Swerdlow, Anthony J (author)
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Ashworth, Alan (author)
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Orr, Nick (author)
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Schoemaker, Minouk J (author)
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Anton-Culver, Hoda (author)
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Ziogas, Argyrios (author)
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Bernstein, Leslie (author)
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Clarke Dur, Christina (author)
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Shen, Chen-Yang (author)
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Yu, Jyh-Cherng (author)
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Hsu, Huan-Ming (author)
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Hsiung, Chia-Ni (author)
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Hamann, Ute (author)
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Dünnebier, Thomas (author)
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Rüdiger, Thomas (author)
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Ulrich Ulmer, Hans (author)
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Pharoah, Paul D P (author)
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Dunning, Alison M (author)
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Humphreys, Manjeet K (author)
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Wang, Qin (author)
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Cox, Angela (author)
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Cross, Simon S (author)
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Reed, Malcolm W R (author)
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Hall, Per (author)
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- Czene, Kamila (author)
- Karolinska Institutet
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Ambrosone, Christine B (author)
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Ademuyiwa, Foluso (author)
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Hwang, Helena (author)
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Eccles, Diana M (author)
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Garcia-Closas, Montserrat (author)
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Figueroa, Jonine D (author)
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Sherman, Mark E (author)
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Lissowska, Jolanta (author)
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Devilee, Peter (author)
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Seynaeve, Caroline (author)
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Tollenaar, R A E M (author)
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Hooning, Maartje J (author)
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Andrulis, Irene L (author)
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Knight, Julia A (author)
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Glendon, Gord (author)
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Mulligan, Anna Marie (author)
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Winqvist, Robert (author)
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Pylkäs, Katri (author)
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Jukkola-Vuorinen, Arja (author)
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Grip, Mervi (author)
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John, Esther M (author)
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Miron, Alexander (author)
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Grenaker Alnaes, Grethe (author)
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Kristensen, Vessela (author)
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Borresen-Dale, Anne-Lise (author)
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Giles, Graham G (author)
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Baglietto, Laura (author)
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McLean, Catriona A (author)
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Severi, Gianluca (author)
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Kosel, Matthew L (author)
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Pankratz, V Shane (author)
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Slager, Susan (author)
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Olson, Janet E (author)
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Radice, Paolo (author)
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Peterlongo, Paolo (author)
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Manoukian, Siranoush (author)
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Barile, Monica (author)
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Lambrechts, Diether (author)
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Hatse, Sigrid (author)
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Dieudonne, Anne-Sophie (author)
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Christiaens, Marie-Rose (author)
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Chenevix-Trench, Georgia (author)
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Investigators, Kconfab (author)
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Group, Aocs (author)
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Beesley, Jonathan (author)
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Chen, Xiaoqing (author)
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Mannermaa, Arto (author)
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Kosma, Veli-Matti (author)
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Hartikainen, Jaana M (author)
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Soini, Ylermi (author)
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Easton, Douglas F (author)
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Couch, Fergus J (author)
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(creator_code:org_t)
- 2012
- 2012
- English.
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In: Cancer Research. - 0008-5472 .- 1538-7445. ; 72, s. 1795-
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The 19p13.1 breast cancer susceptibility locus is a modifier of breast cancer risk in BRCA1 mutation carriers and is also associated with risk of ovarian cancer. Here we investigated 19p13.1 variation and risk of breast cancer subtypes, defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor-2 (HER2) status, using 48,869 breast cancer cases and 49,787 controls from the Breast Cancer Association Consortium (BCAC). Variants from 19p13.1 were not associated with breast cancer overall or with ER-positive breast cancer but were significantly associated with ER-negative breast cancer risk [rs8170 Odds Ratio (OR)=1.10, 95% Confidence Interval (CI) 1.05 - 1.15, p=3.49 x 10-5] and triple negative (TN) (ER, PR and HER2 negative) breast cancer [rs8170 OR=1.22, 95% CI 1.13 - 1.31, p=2.22 x 10-7]. However, rs8170 was no longer associated with ER-negative breast cancer risk when TN cases were excluded [OR=0.98, 95% CI 0.89 - 1.07, p=0.62]. In addition, a combined analysis of TN cases from BCAC and the Triple Negative Breast Cancer Consortium (TNBCC) (n=3,566) identified a genome-wide significant association between rs8170 and TN breast cancer risk [OR=1.25, 95% CI 1.18 - 1.33, p=3.31 x 10-13]. Thus, 19p13.1 is the first triple negative-specific breast cancer risk locus and the first locus specific to a histological subtype defined by ER, PR, and HER2 to be identified. These findings provide convincing evidence that genetic susceptibility to breast cancer varies by tumor subtype and that triple negative tumors and other subtypes likely arise through distinct etiologic pathways.
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Stevens, Kristen ...
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Fredericksen, Za ...
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Vachon, Celine M
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Wang, Xianshu
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Margolin, Sara
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Lindblom, Annika
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show more...
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Nevanlinna, Heli
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Greco, Dario
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Aittomäki, Krist ...
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Blomqvist, Carl
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Chang-Claude, Je ...
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Vrieling, Alina
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Flesch-Janys, Di ...
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Sinn, Hans-Peter
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Wang-Gohrke, Sha ...
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Nickels, Stefan
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Brauch, Hiltrud
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Ko, Yon-Dschun
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Fischer, Hans-Pe ...
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Network, The Gen ...
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Schmutzler, Rita ...
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Meindl, Alfons
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Bartram, Claus R
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Schott, Sarah
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Engel, Christoph
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Godwin, Andrew K
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Weaver, Joellen
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Pathak, Harsh B
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Sharma, Priyanka
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Brenner, Hermann
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Muller, Heiko
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Arndt, Volker
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Stegmaier, Chris ...
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Miron, Penelope
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Yannoukakos, Dra ...
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Stavropoulou, Al ...
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Fountzilas, Geor ...
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Gogas, Helen J
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Swann, Ruth
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Dwek, Miriam
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Perkins, Katheri ...
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Milne, Roger L
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Benítez, Javier
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Zamora, M Pilar
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Ignacio Arias Pé ...
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Bojesen, Stig E
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Nielsen, Sune F
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Nordestgaard, Bo ...
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Flyger, Henrik
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Guénel, Pascal
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Truong, Thérèse
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Menegaux, Floren ...
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Cordina-Duverger ...
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Burwinkel, Barba ...
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Marmé, Frederick
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Schneeweiss, And ...
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Sohn, Christof
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Sawyer, Elinor
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Tomlinson, Ian
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Kerin, Michael J
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Peto, Julian
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Johnson, Nichola
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Fletcher, Olivia
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Dos Santos Silva ...
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Fasching, Peter ...
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Beckmann, Matthi ...
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Hartmann, Arndt
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Ekici, Arif B
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Lophatananon, Ar ...
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Muir, Kenneth
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Puttawibul, Putt ...
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Wiangnon, Surapo ...
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Schmidt, Marjank ...
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Broeks, Annegien
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Braaf, Linde M
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Rosenberg, Efrai ...
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Hopper, John L
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Apicella, Carmel
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Park, Daniel J
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Southey, Melissa ...
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Swerdlow, Anthon ...
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Ashworth, Alan
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Orr, Nick
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Schoemaker, Mino ...
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Anton-Culver, Ho ...
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Ziogas, Argyrios
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Bernstein, Lesli ...
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Clarke Dur, Chri ...
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Shen, Chen-Yang
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Yu, Jyh-Cherng
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Hsu, Huan-Ming
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Hsiung, Chia-Ni
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Hamann, Ute
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Dünnebier, Thoma ...
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Rüdiger, Thomas
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Ulrich Ulmer, Ha ...
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Pharoah, Paul D ...
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Dunning, Alison ...
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Humphreys, Manje ...
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Wang, Qin
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Cox, Angela
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Cross, Simon S
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Reed, Malcolm W ...
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Hall, Per
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Czene, Kamila
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Ambrosone, Chris ...
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Ademuyiwa, Folus ...
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Hwang, Helena
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Eccles, Diana M
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Garcia-Closas, M ...
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Figueroa, Jonine ...
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Sherman, Mark E
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Lissowska, Jolan ...
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Devilee, Peter
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Seynaeve, Caroli ...
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Tollenaar, R A E ...
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Hooning, Maartje ...
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Andrulis, Irene ...
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Knight, Julia A
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Glendon, Gord
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Mulligan, Anna M ...
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Winqvist, Robert
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Pylkäs, Katri
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Jukkola-Vuorinen ...
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Grip, Mervi
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John, Esther M
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Miron, Alexander
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Grenaker Alnaes, ...
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Kristensen, Vess ...
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Borresen-Dale, A ...
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Giles, Graham G
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Baglietto, Laura
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McLean, Catriona ...
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Severi, Gianluca
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Kosel, Matthew L
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Pankratz, V Shan ...
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Slager, Susan
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Olson, Janet E
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Radice, Paolo
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Peterlongo, Paol ...
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Manoukian, Siran ...
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Barile, Monica
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Lambrechts, Diet ...
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Hatse, Sigrid
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Dieudonne, Anne- ...
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Christiaens, Mar ...
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Chenevix-Trench, ...
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Investigators, K ...
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Group, Aocs
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Beesley, Jonatha ...
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Chen, Xiaoqing
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Mannermaa, Arto
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Kosma, Veli-Matt ...
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Hartikainen, Jaa ...
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Soini, Ylermi
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Easton, Douglas ...
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Couch, Fergus J
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- Articles in the publication
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Cancer Research
- By the university
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Uppsala University
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Karolinska Institutet