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Age and sex specifi...
Age and sex specific reference intervals across life-span for insulin-like growth factor binding protein 3 (IGFBP-3) and the IGF-I/IGFBP-3 ratio measured by new automated chemiluminescence assays.
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Friedrich, Nele (author)
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Wolthers, Ole D (author)
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Arafat, Ayman M (author)
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Emeny, Rebecca T (author)
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Spranger, Joachim (author)
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- Roswall, Josefine (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Kratzsch, Jürgen (author)
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Grabe, Hans J (author)
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Hübener, Christoph (author)
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Pfeiffer, Andreas F H (author)
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Doering, Angela (author)
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Bielohuby, Maximilian (author)
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- Dahlgren, Jovanna, 1964 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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Frystyk, Jan (author)
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Wallaschofski, Henri (author)
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Bidlingmaier, Martin (author)
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(creator_code:org_t)
- The Endocrine Society, 2014
- 2014
- English.
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In: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 99:5
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
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- Context: Measurement of IGFBP-3 can aid the diagnosis of growth hormone related diseases. Furthermore, epidemiological studies suggest that IGFBP-3 and the molar IGF-I/IGFBP-3 ratio are associated with clinical endpoints like cancer or cardiovascular disease. However, their clinical use is limited by the lack of validated reference intervals. Objectives: Establishment of age- and sex-specific reference intervals for IGFBP-3 and the molar IGF-I/IGFBP-3 ratio by newly developed automated immunoassays. Setting: Multicentre study with samples from 11 cohorts from the USA, Canada and Europe Participants: 14,970 subjects healthy subjects covering all ages from birth to senescence. Main outcome measures: Concentrations of IGFBP-3 and the IGF-I/IGFBP-3 ratio as determined by the IDS iSYS IGF-I and IGFBP-3 assays. Results: Both the concentration of IGFBP-3 and the IGF-I/IGFBP-3 ratio are mainly determined by age. IGFBP-3 concentrations increase until the age of 22 years, with a plateau being visible between 15 and 25 years. Determined by the high peripubertal peak in IGF-I, the peak in the IGF-I/IGFBP-3 ratio occurs already around the age of 15, with a slightly earlier and higher peak in females. Beyond the age of 60, IGFBP-3 concentrations remain higher in females, whereas IGF-I as well as the IGF-I/IGFBP-3 ratio remain significantly higher in males. Conclusions: We present an extensive set of assay specific, age and sex-adjusted normative data for concentrations of IGFBP-3 and the molar IGF-I/IGFBP-3 ratio and demonstrate distinct sex specific differences across lifespan.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Friedrich, Nele
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Wolthers, Ole D
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Arafat, Ayman M
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Emeny, Rebecca T
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Spranger, Joachi ...
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Roswall, Josefin ...
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show more...
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Kratzsch, Jürgen
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Grabe, Hans J
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Hübener, Christo ...
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Pfeiffer, Andrea ...
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Doering, Angela
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Bielohuby, Maxim ...
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Dahlgren, Jovann ...
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Frystyk, Jan
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Wallaschofski, H ...
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Bidlingmaier, Ma ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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The Journal of c ...
- By the university
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University of Gothenburg