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Lithium Response in...
Lithium Response in Bipolar Disorder is Associated with Focal Adhesion and PI3K-Akt Networks: A Multi-omics Replication Study.
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Kelsoe, John (author)
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Ou, Anna (author)
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Rosenthal, Sara (author)
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show more...
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Adli, Mazda (author)
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Akiyama, Kazufumi (author)
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Akula, Nirmala (author)
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Alda, Martin (author)
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Amare, Azmeraw T (author)
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Ardau, Raffaella (author)
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Arias, Bárbara (author)
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Aubry, Jean-Michel (author)
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- Backlund, Lena (author)
- Karolinska Institutet
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Banzato, Claudio (author)
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Bauer, Michael (author)
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Baune, Bernhard (author)
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Bellivier, Frank (author)
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Benabarre, Antonio (author)
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Bengesser, Susanne (author)
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Abesh, Bhattacharjee (author)
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Biernacka, Joanna (author)
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Bui, Elise (author)
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Cervantes, Pablo (author)
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Chen, Guo-Bo (author)
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Chen, Hsi-Chung (author)
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- Chillotti, Caterina (author)
- Karolinska Institutet
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Cichon, Sven (author)
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Clark, Scott (author)
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Colom, Francesc (author)
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Cousins, David (author)
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Cruceanu, Cristiana (author)
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Czerski, Piotr (author)
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Dantas, Clarissa (author)
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Dayer, Alexandre (author)
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Degenhardt, Franziska (author)
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DePaulo, J Raymond (author)
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Etain, Bruno (author)
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Falkai, Peter (author)
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Fellendorf, Frederike (author)
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Ferensztajn-Rochowiak, Ewa (author)
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Forstner, Andreas J (author)
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- Frisen, Louise (author)
- Karolinska Institutet
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Frye, Mark (author)
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Fullerton, Janice (author)
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Gard, Sebastien (author)
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Garnham, Julie (author)
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Goes, Fernando (author)
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Grigoroiu-Serbanescu, Maria (author)
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Grof, Paul (author)
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Gruber, Oliver (author)
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Hashimoto, Ryota (author)
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Hauser, Joanna (author)
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Heilbronner, Urs (author)
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Herms, Stefan (author)
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Hoffmann, Per (author)
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Hofmann, Andrea (author)
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Hou, Liping (author)
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Jamain, Stéphane (author)
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Jiménez, Esther (author)
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Kahn, Jean-Pierre (author)
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Kassem, Layla (author)
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Kato, Tadafumi (author)
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Kittel-Schneider, Sarah (author)
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König, Barbara (author)
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Kuo, Po-Hsiu (author)
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Kusumi, Ichiro (author)
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Dalkner, Nina (author)
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Laje, Gonzalo (author)
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- Landén, Mikael, 1966 (author)
- Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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Lavebratt, Catharina (author)
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Leboyer, Marion (author)
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Leckband, Susan (author)
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Jaramillo, Carlos López (author)
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MacQueen, Glenda (author)
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- Maj, Mario (author)
- Karolinska Institutet
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Manchia, Mirko (author)
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Marie-Claire, Cynthia (author)
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- Martinsson, Lina (author)
- Karolinska Institutet
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Mattheisen, Manuel (author)
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McCarthy, Michael (author)
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McElroy, Susan (author)
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McMahon, Francis (author)
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Mitchell, Philip (author)
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Mitjans, Marina (author)
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Mondimore, Francis (author)
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Monteleone, Palmiero (author)
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Nievergelt, Caroline (author)
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Nöthen, Markus (author)
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Novak, Tomas (author)
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Osby, Urban (author)
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Ozaki, Norio (author)
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Papiol, Sergi (author)
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Perlis, Roy (author)
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Pfennig, Andrea (author)
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Potash, James (author)
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Reich-Erkelenz, Daniela (author)
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Reif, Andreas (author)
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Reininghaus, Eva (author)
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Rietschel, Marcella (author)
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Rouleau, Guy (author)
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Rybakowski, Janusz K (author)
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Schalling, Martin (author)
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Schofield, Peter (author)
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Schubert, Klaus Oliver (author)
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Schulze, Thomas (author)
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Schweizer, Barbara (author)
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Seemüller, Florian (author)
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Severino, Giovanni (author)
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Shekhtman, Tatyana (author)
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Shilling, Paul (author)
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Shimoda, Kazutaka (author)
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Simhandl, Christian (author)
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Slaney, Claire (author)
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Squassina, Alessio (author)
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Stamm, Thomas (author)
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Stopkova, Pavla (author)
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Tighe, Sarah (author)
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Tortorella, Alfonso (author)
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Turecki, Gustavo (author)
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Vieta, Eduard (author)
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Volkert, Julia (author)
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Witt, Stephanie (author)
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Wray, Naomi (author)
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Wright, Adam (author)
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Young, Trevor (author)
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Zandi, Peter (author)
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Zompo, Maria Del (author)
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(creator_code:org_t)
- 2023
- English.
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In: Research square.
- Related links:
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https://gup.ub.gu.se...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Subject headings
Close
- Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2,039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Publication and Content Type
- vet (subject category)
- ovr (subject category)
To the university's database
- By the author/editor
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Kelsoe, John
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Ou, Anna
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Rosenthal, Sara
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Adli, Mazda
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Akiyama, Kazufum ...
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Akula, Nirmala
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show more...
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Alda, Martin
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Amare, Azmeraw T
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Ardau, Raffaella
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Arias, Bárbara
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Aubry, Jean-Mich ...
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Backlund, Lena
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Banzato, Claudio
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Bauer, Michael
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Baune, Bernhard
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Bellivier, Frank
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Benabarre, Anton ...
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Bengesser, Susan ...
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Abesh, Bhattacha ...
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Biernacka, Joann ...
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Bui, Elise
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Cervantes, Pablo
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Chen, Guo-Bo
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Chen, Hsi-Chung
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Chillotti, Cater ...
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Cichon, Sven
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Clark, Scott
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Colom, Francesc
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Cousins, David
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Cruceanu, Cristi ...
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Czerski, Piotr
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Dantas, Clarissa
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Dayer, Alexandre
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Degenhardt, Fran ...
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DePaulo, J Raymo ...
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Etain, Bruno
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Falkai, Peter
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Fellendorf, Fred ...
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Ferensztajn-Roch ...
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Forstner, Andrea ...
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Frisen, Louise
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Frye, Mark
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Fullerton, Janic ...
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Gard, Sebastien
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Garnham, Julie
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Goes, Fernando
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Grigoroiu-Serban ...
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Grof, Paul
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Gruber, Oliver
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Hashimoto, Ryota
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Hauser, Joanna
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Heilbronner, Urs
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Herms, Stefan
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Hoffmann, Per
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Hofmann, Andrea
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Hou, Liping
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Jamain, Stéphane
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Jiménez, Esther
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Kahn, Jean-Pierr ...
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Kassem, Layla
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Kato, Tadafumi
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Kittel-Schneider ...
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König, Barbara
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Kuo, Po-Hsiu
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Kusumi, Ichiro
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Dalkner, Nina
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Laje, Gonzalo
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Landén, Mikael, ...
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Lavebratt, Catha ...
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Leboyer, Marion
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Leckband, Susan
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Jaramillo, Carlo ...
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MacQueen, Glenda
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Maj, Mario
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Manchia, Mirko
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Marie-Claire, Cy ...
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Martinsson, Lina
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Mattheisen, Manu ...
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McCarthy, Michae ...
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McElroy, Susan
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McMahon, Francis
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Mitchell, Philip
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Mitjans, Marina
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Mondimore, Franc ...
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Monteleone, Palm ...
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Nievergelt, Caro ...
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Nöthen, Markus
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Novak, Tomas
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Osby, Urban
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Ozaki, Norio
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Papiol, Sergi
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Perlis, Roy
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Pfennig, Andrea
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Potash, James
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Reich-Erkelenz, ...
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Reif, Andreas
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Reininghaus, Eva
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Rietschel, Marce ...
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Rouleau, Guy
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Rybakowski, Janu ...
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Schalling, Marti ...
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Schofield, Peter
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Schubert, Klaus ...
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Schulze, Thomas
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Schweizer, Barba ...
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Seemüller, Flori ...
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Severino, Giovan ...
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Shekhtman, Tatya ...
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Shilling, Paul
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Shimoda, Kazutak ...
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Simhandl, Christ ...
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Slaney, Claire
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Squassina, Aless ...
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Stamm, Thomas
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Stopkova, Pavla
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Tighe, Sarah
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Tortorella, Alfo ...
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Turecki, Gustavo
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Vieta, Eduard
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Volkert, Julia
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Witt, Stephanie
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Wray, Naomi
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Wright, Adam
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Young, Trevor
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Zandi, Peter
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Zompo, Maria Del
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
- Research square
- By the university
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University of Gothenburg
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Karolinska Institutet