Search: (WFRF:(Psaty Bruce M.)) lar1:(ki) pers:(Mangino Massimo) pers:(Munroe Patricia B.) >
Meta-analysis ident...
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
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Heid, Iris M (author)
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Jackson, Anne U (author)
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Randall, Joshua C (author)
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show more...
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Winkler, Thomas W (author)
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Qi, Lu (author)
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Steinthorsdottir, Valgerdur (author)
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Thorleifsson, Gudmar (author)
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Zillikens, M Carola (author)
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Speliotes, Elizabeth K (author)
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Mägi, Reedik (author)
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Workalemahu, Tsegaselassie (author)
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White, Charles C (author)
-
Bouatia-Naji, Nabila (author)
-
Harris, Tamara B (author)
-
Berndt, Sonja I (author)
-
- Ingelsson, Erik (author)
- Karolinska Institutet
-
Willer, Cristen J (author)
-
Weedon, Michael N (author)
-
Luan, Jian'an (author)
-
Vedantam, Sailaja (author)
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Esko, Tõnu (author)
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Kilpeläinen, Tuomas O (author)
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Kutalik, Zoltán (author)
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Li, Shengxu (author)
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Monda, Keri L (author)
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Dixon, Anna L (author)
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Holmes, Christopher C (author)
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Kaplan, Lee M (author)
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Liang, Liming (author)
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Min, Josine L (author)
-
Moffatt, Miriam F (author)
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Molony, Cliona (author)
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Nicholson, George (author)
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Schadt, Eric E (author)
-
Zondervan, Krina T (author)
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Feitosa, Mary F (author)
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Ferreira, Teresa (author)
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Allen, Hana Lango (author)
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Weyant, Robert J (author)
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Wheeler, Eleanor (author)
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Wood, Andrew R (author)
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Estrada, Karol (author)
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Goddard, Michael E (author)
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Lettre, Guillaume (author)
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Mangino, Massimo (author)
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Nyholt, Dale R (author)
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Purcell, Shaun (author)
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Smith, Albert Vernon (author)
-
Visscher, Peter M (author)
-
Yang, Jian (author)
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McCarroll, Steven A (author)
-
Nemesh, James (author)
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Voight, Benjamin F (author)
-
Absher, Devin (author)
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Amin, Najaf (author)
-
Aspelund, Thor (author)
-
Coin, Lachlan (author)
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Glazer, Nicole L (author)
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Hayward, Caroline (author)
-
Heard-Costa, Nancy L (author)
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Hottenga, Jouke-Jan (author)
-
- Johansson, Åsa (author)
- Uppsala universitet,Genomik,Gyllensten
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Johnson, Toby (author)
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Kaakinen, Marika (author)
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Kapur, Karen (author)
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Ketkar, Shamika (author)
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Knowles, Joshua W (author)
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Kraft, Peter (author)
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Kraja, Aldi T (author)
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Lamina, Claudia (author)
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Leitzmann, Michael F (author)
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McKnight, Barbara (author)
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Morris, Andrew P (author)
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Ong, Ken K (author)
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Perry, John R B (author)
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Peters, Marjolein J (author)
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Polasek, Ozren (author)
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Prokopenko, Inga (author)
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Rayner, Nigel W (author)
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Ripatti, Samuli (author)
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Rivadeneira, Fernando (author)
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Robertson, Neil R (author)
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Sanna, Serena (author)
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Sovio, Ulla (author)
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Surakka, Ida (author)
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Teumer, Alexander (author)
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van Wingerden, Sophie (author)
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Vitart, Veronique (author)
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Zhao, Jing Hua (author)
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Cavalcanti-Proença, Christine (author)
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Chines, Peter S (author)
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Fisher, Eva (author)
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Kulzer, Jennifer R (author)
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Lecoeur, Cecile (author)
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Narisu, Narisu (author)
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Sandholt, Camilla (author)
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Scott, Laura J (author)
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Silander, Kaisa (author)
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Stark, Klaus (author)
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Tammesoo, Mari-Liis (author)
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Teslovich, Tanya M (author)
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Timpson, Nicholas John (author)
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Watanabe, Richard M (author)
-
Welch, Ryan (author)
-
Chasman, Daniel I (author)
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Cooper, Matthew N (author)
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Kettunen, Johannes (author)
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Lawrence, Robert W (author)
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Pellikka, Niina (author)
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Perola, Markus (author)
-
- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Institute of Medicine, Department of Internal Medicine
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Alavere, Helene (author)
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- Almgren, Peter (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Atwood, Larry D (author)
-
Bennett, Amanda J (author)
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Biffar, Reiner (author)
-
Bonnycastle, Lori L (author)
-
Bornstein, Stefan R (author)
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Buchanan, Thomas A (author)
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Campbell, Harry (author)
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Day, Ian N M (author)
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Dei, Mariano (author)
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Dörr, Marcus (author)
-
Elliott, Paul (author)
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Erdos, Michael R (author)
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Eriksson, Johan G (author)
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Freimer, Nelson B (author)
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Fu, Mao (author)
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Gaget, Stefan (author)
-
Geus, Eco J C (author)
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Gjesing, Anette P (author)
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Grallert, Harald (author)
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Grässler, Jürgen (author)
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Groves, Christopher J (author)
-
Guiducci, Candace (author)
-
Hartikainen, Anna-Liisa (author)
-
Hassanali, Neelam (author)
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Havulinna, Aki S (author)
-
Herzig, Karl-Heinz (author)
-
Hicks, Andrew A (author)
-
Hui, Jennie (author)
-
- Igl, Wilmar (author)
- Uppsala universitet,Institutionen för genetik och patologi
-
Jousilahti, Pekka (author)
-
Jula, Antti (author)
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Kajantie, Eero (author)
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Kinnunen, Leena (author)
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Kolcic, Ivana (author)
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Koskinen, Seppo (author)
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Kovacs, Peter (author)
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Kroemer, Heyo K (author)
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Krzelj, Vjekoslav (author)
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Kuusisto, Johanna (author)
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Kvaloy, Kirsti (author)
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Laitinen, Jaana (author)
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Lantieri, Olivier (author)
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Lathrop, G Mark (author)
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Lokki, Marja-Liisa (author)
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Luben, Robert N (author)
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Ludwig, Barbara (author)
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McArdle, Wendy L (author)
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McCarthy, Anne (author)
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Morken, Mario A (author)
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Nelis, Mari (author)
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Neville, Matt J (author)
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Paré, Guillaume (author)
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Parker, Alex N (author)
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Peden, John F (author)
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Pichler, Irene (author)
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Pietiläinen, Kirsi H (author)
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Platou, Carl G P (author)
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Pouta, Anneli (author)
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- Ridderstråle, Martin (author)
- Lund University,Lunds universitet,Diabetes - klinisk obesitasforskning,Forskargrupper vid Lunds universitet,Diabetes - Clinical Obesity,Lund University Research Groups
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Samani, Nilesh J (author)
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Saramies, Jouko (author)
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Sinisalo, Juha (author)
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Smit, Jan H (author)
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- Strawbridge, Rona J (author)
- Karolinska Institutet
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Stringham, Heather M (author)
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Swift, Amy J (author)
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Teder-Laving, Maris (author)
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Thomson, Brian (author)
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Usala, Gianluca (author)
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van Meurs, Joyce B J (author)
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van Ommen, Gert-Jan (author)
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Vatin, Vincent (author)
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Volpato, Claudia B (author)
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Wallaschofski, Henri (author)
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Walters, G Bragi (author)
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Widen, Elisabeth (author)
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Wild, Sarah H (author)
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Willemsen, Gonneke (author)
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Witte, Daniel R (author)
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Zgaga, Lina (author)
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Zitting, Paavo (author)
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Beilby, John P (author)
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James, Alan L (author)
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Kähönen, Mika (author)
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Lehtimäki, Terho (author)
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Nieminen, Markku S (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine
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Palmer, Lyle J (author)
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Raitakari, Olli (author)
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Ridker, Paul M (author)
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Stumvoll, Michael (author)
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Tönjes, Anke (author)
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Viikari, Jorma (author)
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Balkau, Beverley (author)
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Ben-Shlomo, Yoav (author)
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Bergman, Richard N (author)
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Boeing, Heiner (author)
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Smith, George Davey (author)
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Ebrahim, Shah (author)
-
Froguel, Philippe (author)
-
Hansen, Torben (author)
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Hengstenberg, Christian (author)
-
Hveem, Kristian (author)
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Isomaa, Bo (author)
-
Jørgensen, Torben (author)
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Karpe, Fredrik (author)
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Khaw, Kay-Tee (author)
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Laakso, Markku (author)
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Lawlor, Debbie A (author)
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Marre, Michel (author)
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Meitinger, Thomas (author)
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Metspalu, Andres (author)
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Midthjell, Kristian (author)
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Pedersen, Oluf (author)
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Salomaa, Veikko (author)
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Schwarz, Peter E H (author)
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Tuomi, Tiinamaija (author)
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Tuomilehto, Jaakko (author)
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Valle, Timo T (author)
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Wareham, Nicholas J (author)
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Arnold, Alice M (author)
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Beckmann, Jacques S (author)
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Bergmann, Sven (author)
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Boerwinkle, Eric (author)
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Boomsma, Dorret I (author)
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Caulfield, Mark J (author)
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Collins, Francis S (author)
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Eiriksdottir, Gudny (author)
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Gudnason, Vilmundur (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Institutionen för genetik och patologi,Gyllensten
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- Hamsten, Anders (author)
- Karolinska Institutet
-
Hattersley, Andrew T (author)
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Hofman, Albert (author)
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Hu, Frank B (author)
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Illig, Thomas (author)
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Iribarren, Carlos (author)
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Jarvelin, Marjo-Riitta (author)
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Kao, W H Linda (author)
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Kaprio, Jaakko (author)
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Launer, Lenore J (author)
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Munroe, Patricia B (author)
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Oostra, Ben (author)
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Penninx, Brenda W (author)
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Pramstaller, Peter P (author)
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Psaty, Bruce M (author)
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Quertermous, Thomas (author)
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Rissanen, Aila (author)
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Rudan, Igor (author)
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Shuldiner, Alan R (author)
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Soranzo, Nicole (author)
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Spector, Timothy D (author)
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- Syvänen, Ann-Christine (author)
- Uppsala universitet,Molekylär medicin
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Uda, Manuela (author)
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Uitterlinden, André (author)
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Völzke, Henry (author)
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Vollenweider, Peter (author)
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Wilson, James F (author)
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Witteman, Jacqueline C (author)
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Wright, Alan F (author)
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Abecasis, Gonçalo R (author)
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Boehnke, Michael (author)
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Borecki, Ingrid B (author)
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Deloukas, Panos (author)
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Frayling, Timothy M (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Haritunians, Talin (author)
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Hunter, David J (author)
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Kaplan, Robert C (author)
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North, Kari E (author)
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O'Connell, Jeffrey R (author)
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Peltonen, Leena (author)
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Schlessinger, David (author)
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Strachan, David P (author)
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Hirschhorn, Joel N (author)
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Assimes, Themistocles L (author)
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Wichmann, H-Erich (author)
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Thorsteinsdottir, Unnur (author)
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van Duijn, Cornelia M (author)
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Stefansson, Kari (author)
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Cupples, L Adrienne (author)
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Loos, Ruth J F (author)
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Barroso, Inês (author)
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McCarthy, Mark I (author)
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Fox, Caroline S (author)
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Mohlke, Karen L (author)
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Lindgren, Cecilia M (author)
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Luan, Jianan (author)
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(creator_code:org_t)
- 2010-10-10
- 2010
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 949-960
- Related links:
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https://cdr.lib.unc....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Subject headings
Close
- Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Heid, Iris M
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Jackson, Anne U
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Randall, Joshua ...
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Winkler, Thomas ...
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Qi, Lu
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Steinthorsdottir ...
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show more...
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Thorleifsson, Gu ...
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Zillikens, M Car ...
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Speliotes, Eliza ...
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Mägi, Reedik
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Workalemahu, Tse ...
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White, Charles C
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Bouatia-Naji, Na ...
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Harris, Tamara B
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Berndt, Sonja I
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Ingelsson, Erik
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Willer, Cristen ...
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Weedon, Michael ...
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Luan, Jian'an
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Vedantam, Sailaj ...
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Esko, Tõnu
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Kilpeläinen, Tuo ...
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Kutalik, Zoltán
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Li, Shengxu
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Monda, Keri L
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Dixon, Anna L
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Holmes, Christop ...
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Kaplan, Lee M
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Liang, Liming
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Min, Josine L
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Moffatt, Miriam ...
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Molony, Cliona
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Nicholson, Georg ...
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Schadt, Eric E
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Zondervan, Krina ...
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Feitosa, Mary F
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Ferreira, Teresa
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Allen, Hana Lang ...
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Weyant, Robert J
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Wheeler, Eleanor
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Wood, Andrew R
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Estrada, Karol
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Goddard, Michael ...
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Lettre, Guillaum ...
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Mangino, Massimo
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Nyholt, Dale R
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Purcell, Shaun
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Smith, Albert Ve ...
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Visscher, Peter ...
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Yang, Jian
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McCarroll, Steve ...
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Nemesh, James
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Voight, Benjamin ...
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Absher, Devin
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Amin, Najaf
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Aspelund, Thor
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Coin, Lachlan
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Glazer, Nicole L
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Hayward, Carolin ...
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Heard-Costa, Nan ...
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Hottenga, Jouke- ...
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Johansson, Åsa
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Johnson, Toby
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Kaakinen, Marika
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Kapur, Karen
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Ketkar, Shamika
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Knowles, Joshua ...
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Kraft, Peter
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Kraja, Aldi T
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Lamina, Claudia
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Leitzmann, Micha ...
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McKnight, Barbar ...
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Morris, Andrew P
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Ong, Ken K
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Perry, John R B
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Peters, Marjolei ...
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Polasek, Ozren
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Prokopenko, Inga
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Rayner, Nigel W
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Ripatti, Samuli
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Rivadeneira, Fer ...
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Robertson, Neil ...
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Sanna, Serena
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Sovio, Ulla
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Surakka, Ida
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Teumer, Alexande ...
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van Wingerden, S ...
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Vitart, Veroniqu ...
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Zhao, Jing Hua
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Cavalcanti-Proen ...
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Chines, Peter S
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Fisher, Eva
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Kulzer, Jennifer ...
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Lecoeur, Cecile
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Narisu, Narisu
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Sandholt, Camill ...
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Scott, Laura J
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Silander, Kaisa
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Stark, Klaus
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Tammesoo, Mari-L ...
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Teslovich, Tanya ...
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Timpson, Nichola ...
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Watanabe, Richar ...
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Welch, Ryan
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Chasman, Daniel ...
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Cooper, Matthew ...
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Jansson, John-Ol ...
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Kettunen, Johann ...
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Lawrence, Robert ...
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Pellikka, Niina
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Perola, Markus
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Vandenput, Liesb ...
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Alavere, Helene
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Almgren, Peter
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Atwood, Larry D
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Bennett, Amanda ...
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Biffar, Reiner
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Bonnycastle, Lor ...
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Bornstein, Stefa ...
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Buchanan, Thomas ...
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Campbell, Harry
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Day, Ian N M
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Dei, Mariano
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Dörr, Marcus
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Elliott, Paul
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Erdos, Michael R
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Eriksson, Johan ...
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Freimer, Nelson ...
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Fu, Mao
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Gaget, Stefan
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Geus, Eco J C
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Gjesing, Anette ...
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Grallert, Harald
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Grässler, Jürgen
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Groves, Christop ...
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Guiducci, Candac ...
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Hartikainen, Ann ...
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Hassanali, Neela ...
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Havulinna, Aki S
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Herzig, Karl-Hei ...
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Hicks, Andrew A
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Hui, Jennie
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Igl, Wilmar
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Jousilahti, Pekk ...
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Jula, Antti
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Kajantie, Eero
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Kinnunen, Leena
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Kolcic, Ivana
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Koskinen, Seppo
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Kovacs, Peter
-
Kroemer, Heyo K
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Krzelj, Vjekosla ...
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Kuusisto, Johann ...
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Kvaloy, Kirsti
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Laitinen, Jaana
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Lantieri, Olivie ...
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Lathrop, G Mark
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Lokki, Marja-Lii ...
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Luben, Robert N
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Ludwig, Barbara
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McArdle, Wendy L
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McCarthy, Anne
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Morken, Mario A
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Nelis, Mari
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Neville, Matt J
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Paré, Guillaume
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Parker, Alex N
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Peden, John F
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Pichler, Irene
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Pietiläinen, Kir ...
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Platou, Carl G P
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Pouta, Anneli
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Ridderstråle, Ma ...
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Samani, Nilesh J
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Saramies, Jouko
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Sinisalo, Juha
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Smit, Jan H
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Strawbridge, Ron ...
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Stringham, Heath ...
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Swift, Amy J
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Teder-Laving, Ma ...
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Thomson, Brian
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Usala, Gianluca
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van Meurs, Joyce ...
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van Ommen, Gert- ...
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Vatin, Vincent
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Volpato, Claudia ...
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Wallaschofski, H ...
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Walters, G Bragi
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Widen, Elisabeth
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Wild, Sarah H
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Willemsen, Gonne ...
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Witte, Daniel R
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Zgaga, Lina
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Zitting, Paavo
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Beilby, John P
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James, Alan L
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Kähönen, Mika
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Lehtimäki, Terho
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Nieminen, Markku ...
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Ohlsson, Claes, ...
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Palmer, Lyle J
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Raitakari, Olli
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Ridker, Paul M
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Stumvoll, Michae ...
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Tönjes, Anke
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Viikari, Jorma
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Balkau, Beverley
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Ben-Shlomo, Yoav
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Bergman, Richard ...
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Boeing, Heiner
-
Smith, George Da ...
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Ebrahim, Shah
-
Froguel, Philipp ...
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Hansen, Torben
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Hengstenberg, Ch ...
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Hveem, Kristian
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Isomaa, Bo
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Jørgensen, Torbe ...
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Karpe, Fredrik
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Khaw, Kay-Tee
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Laakso, Markku
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Lawlor, Debbie A
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Marre, Michel
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Meitinger, Thoma ...
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Metspalu, Andres
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Midthjell, Krist ...
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Pedersen, Oluf
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Salomaa, Veikko
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Schwarz, Peter E ...
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Tuomi, Tiinamaij ...
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Tuomilehto, Jaak ...
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Valle, Timo T
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Wareham, Nichola ...
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Arnold, Alice M
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Beckmann, Jacque ...
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Bergmann, Sven
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Boerwinkle, Eric
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Boomsma, Dorret ...
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Caulfield, Mark ...
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Collins, Francis ...
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Eiriksdottir, Gu ...
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Gudnason, Vilmun ...
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Gyllensten, Ulf
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Hamsten, Anders
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Hattersley, Andr ...
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Hofman, Albert
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Hu, Frank B
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Illig, Thomas
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Iribarren, Carlo ...
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Jarvelin, Marjo- ...
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Kao, W H Linda
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Kaprio, Jaakko
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Launer, Lenore J
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Munroe, Patricia ...
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Oostra, Ben
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Penninx, Brenda ...
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Pramstaller, Pet ...
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Psaty, Bruce M
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Quertermous, Tho ...
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Rissanen, Aila
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Rudan, Igor
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Shuldiner, Alan ...
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Soranzo, Nicole
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Spector, Timothy ...
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Syvänen, Ann-Chr ...
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Uda, Manuela
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Uitterlinden, An ...
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Völzke, Henry
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Vollenweider, Pe ...
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Wilson, James F
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Witteman, Jacque ...
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Wright, Alan F
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Abecasis, Gonçal ...
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Boehnke, Michael
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Borecki, Ingrid ...
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Deloukas, Panos
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Frayling, Timoth ...
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Groop, Leif
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Haritunians, Tal ...
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Hunter, David J
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Kaplan, Robert C
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North, Kari E
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O'Connell, Jeffr ...
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Peltonen, Leena
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Schlessinger, Da ...
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Strachan, David ...
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Hirschhorn, Joel ...
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Assimes, Themist ...
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Wichmann, H-Eric ...
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Thorsteinsdottir ...
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van Duijn, Corne ...
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Stefansson, Kari
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Cupples, L Adrie ...
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Loos, Ruth J F
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Barroso, Inês
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McCarthy, Mark I
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Fox, Caroline S
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Mohlke, Karen L
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Lindgren, Cecili ...
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Luan, Jianan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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University of Gothenburg
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Lund University
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Karolinska Institutet