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Smoking as a major ...
Smoking as a major risk factor for cervical cancer and pre-cancer : results from the EPIC cohort
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Roura, Esther (author)
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Castellsagué, Xavier (author)
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Pawlita, Michael (author)
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show more...
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Travier, Noémie (author)
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Waterboer, Tim (author)
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Margall, Núria (author)
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Bosch, F Xavier (author)
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de Sanjosé, Silvia (author)
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- Dillner, Joakim (author)
- Karolinska Institutet
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Gram, Inger T (author)
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Tjønneland, Anne (author)
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Munk, Christian (author)
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Pala, Valeria (author)
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Palli, Domenico (author)
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Khaw, Kay-Tee (author)
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Barnabas, Ruanne V (author)
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Overvad, Kim (author)
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Clavel-Chapelon, Françoise (author)
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Boutron-Ruault, Marie-Christine (author)
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Fagherazzi, Guy (author)
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Kaaks, Rudolf (author)
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- Lukanova, Annekatrin (author)
- Umeå universitet,Patologi
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Steffen, Annika (author)
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Trichopoulou, Antonia (author)
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Trichopoulos, Dimitrios (author)
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Klinaki, Eleni (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Panico, Salvatore (author)
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Bueno-de-Mesquita, H Bas (author)
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Peeters, Petra H (author)
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Lund, Eiliv (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Redondo, M Luisa (author)
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Sánchez, María-José (author)
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Tormo, Maria-José (author)
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Barricarte, Aurelio (author)
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Larrañaga, Nerea (author)
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- Ekström, Johanna (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Hortlund, Maria (author)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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- Lindquist, David (author)
- Umeå universitet,Onkologi
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Wareham, Nick (author)
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Travis, Ruth C (author)
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Rinaldi, Sabina (author)
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Tommasino, Massimo (author)
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Franceschi, Silvia (author)
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Riboli, Elio (author)
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(creator_code:org_t)
- 2014-01-06
- 2014
- English.
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In: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 135:2, s. 453-466
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Subject headings
Close
- A total of 308,036 women were selected from the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate the association between tobacco smoking and the risk of cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC). At baseline, participants completed a questionnaire and provided blood samples. During a mean follow-up time of 9 years, 261 ICC cases and 804 CIN3/CIS cases were reported. In a nested case-control study, the baseline sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis (CT), and Human Herpes Virus 2 (HHV-2). Cervical samples were not available for HPV-DNA analysis in this study. Multivariate analyses were used to estimate associations between smoking and risk of CIN3/CIS and ICC in the cohort and the case-control studies. In the cohort analyses smoking status, duration and intensity showed a 2-fold increased risk of CIN3/CIS and ICC, while time since quitting was associated with a 2-fold reduced risk. In the nested case-control study, consistent associations were observed after adjustment for HPV, CT and HHV-2 serostatus, in both HPV seronegative and seropositive women. Results from this large prospective study confirm the role of tobacco smoking as an important risk factor for both CIN3/CIS and ICC, even after taking into account HPV exposure as determined by HPV serology. The strong beneficial effect of quitting smoking is an important finding that will further support public health policies for smoking cessation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- cohort study
- cervical cancer
- smoking
- HPV serology
- EPIC
- cohort study
- cervical cancer
- smoking
- Human Papillomavirus serology
- EPIC
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Roura, Esther
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Castellsagué, Xa ...
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Pawlita, Michael
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Travier, Noémie
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Waterboer, Tim
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Margall, Núria
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show more...
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Bosch, F Xavier
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de Sanjosé, Silv ...
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Dillner, Joakim
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Gram, Inger T
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Tjønneland, Anne
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Munk, Christian
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Pala, Valeria
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Palli, Domenico
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Khaw, Kay-Tee
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Barnabas, Ruanne ...
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Overvad, Kim
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Clavel-Chapelon, ...
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Boutron-Ruault, ...
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Fagherazzi, Guy
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Kaaks, Rudolf
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Lukanova, Anneka ...
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Steffen, Annika
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Trichopoulou, An ...
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Trichopoulos, Di ...
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Klinaki, Eleni
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Tumino, Rosario
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Sacerdote, Carlo ...
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H
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Lund, Eiliv
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Weiderpass, Elis ...
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Redondo, M Luisa
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Sánchez, María-J ...
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Tormo, Maria-Jos ...
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Barricarte, Aure ...
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Larrañaga, Nerea
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Ekström, Johanna
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Hortlund, Maria
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Lindquist, David
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Wareham, Nick
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Travis, Ruth C
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Rinaldi, Sabina
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Tommasino, Massi ...
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Franceschi, Silv ...
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Riboli, Elio
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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International Jo ...
- By the university
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Umeå University
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Karolinska Institutet
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Lund University