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Criteria for the cl...
Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group
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Kyle, RA (author)
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Child, JA (author)
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Anderson, K (author)
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show more...
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Barlogie, B (author)
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Bataille, R (author)
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Bensinger, W (author)
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Blade, J (author)
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Boccadoro, M (author)
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Dalton, W (author)
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Dimopoulos, M (author)
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Djulbegovic, B (author)
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Drayson, M (author)
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Durie, B (author)
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Facon, T (author)
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Fonseca, R (author)
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- Gahrton, G (author)
- Karolinska Institutet
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Greipp, P (author)
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Harousseau, JL (author)
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Harrington, D (author)
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Hussein, M (author)
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Joshua, D (author)
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Ludwig, H (author)
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Morgan, G (author)
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Oken, M (author)
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Powles, R (author)
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Richardson, P (author)
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Roodman, D (author)
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San Miguel, J (author)
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Shimizu, K (author)
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Shustik, C (author)
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Sirohi, B (author)
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Sonneveld, P (author)
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Tricot, G (author)
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- Turesson, Ingemar (author)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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Van Ness, B (author)
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Vesole, D (author)
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Weber, D (author)
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- Westin, Jan (author)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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Wheatley, K (author)
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(creator_code:org_t)
- 2003-05-28
- 2003
- English.
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In: British Journal of Haematology. - : Wiley. - 0007-1048. ; 121:5, s. 749-757
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Abstract
Subject headings
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- The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/l and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is greater than or equal to 30 g/l and/or bone marrow clonal cells greater than or equal to 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTI. Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/- recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- monoclonal
- classification
- multiple myeloma
- gammopathies
Publication and Content Type
- art (subject category)
- ref (subject category)
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To the university's database
- By the author/editor
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Kyle, RA
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Child, JA
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Anderson, K
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Barlogie, B
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Bataille, R
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Bensinger, W
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show more...
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Blade, J
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Boccadoro, M
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Dalton, W
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Dimopoulos, M
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Djulbegovic, B
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Drayson, M
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Durie, B
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Facon, T
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Fonseca, R
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Gahrton, G
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Greipp, P
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Harousseau, JL
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Harrington, D
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Hussein, M
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Joshua, D
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Ludwig, H
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Morgan, G
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Oken, M
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Powles, R
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Richardson, P
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Roodman, D
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San Miguel, J
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Shimizu, K
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Shustik, C
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Sirohi, B
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Sonneveld, P
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Tricot, G
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Turesson, Ingema ...
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Van Ness, B
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Vesole, D
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Weber, D
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Westin, Jan
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Wheatley, K
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
- Articles in the publication
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British Journal ...
- By the university
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Lund University
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Karolinska Institutet