Loci influencing blood pressure identified using a cardiovascular gene-centric array

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Fältnamn	Indikatorer	Metadata
000		08474naa a2201921 4500
001		oai:lup.lub.lu.se:2273fe6e-736b-43fe-865b-390c202bf114
003		SwePub
008		160401s2013 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://lup.lub.lu.se/record/37483242 URI
024	7	a https://doi.org/10.1093/hmg/dds5552 DOI
040		a (SwePub)lu
041		a engb eng
042		9 SwePub
072	7	a art2 swepub-publicationtype
072	7	a ref2 swepub-contenttype
100	1	a Ganesh, Santhi K.4 aut
245	1 0	a Loci influencing blood pressure identified using a cardiovascular gene-centric array
264		c 2013-01-08
264	1	b Oxford University Press (OUP),c 2013
520		a Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
700	1	a Tragante, Vinicius4 aut
700	1	a Guo, Wei4 aut
700	1	a Guo, Yiran4 aut
700	1	a Lanktree, Matthew B.4 aut
700	1	a Smith, Erin N.4 aut
700	1	a Johnson, Toby4 aut
700	1	a Castillo, Berta Almoguera4 aut
700	1	a Barnard, John4 aut
700	1	a Baumert, Jens4 aut
700	1	a Chang, Yen-Pei Christy4 aut
700	1	a Elbers, Clara C.4 aut
700	1	a Farrall, Martin4 aut
700	1	a Fischer, Mary E.4 aut
700	1	a Franceschini, Nora4 aut
700	1	a Gaunt, Tom R.4 aut
700	1	a Gho, Johannes M. I. H.4 aut
700	1	a Gieger, Christian4 aut
700	1	a Gong, Yan4 aut
700	1	a Isaacs, Aaron4 aut
700	1	a Kleber, Marcus E.4 aut
700	1	a Leach, Irene Mateo4 aut
700	1	a McDonough, Caitrin W.4 aut
700	1	a Meijs, Matthijs F. L.4 aut
700	1	a Melander, Olleu Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups4 aut0 (Swepub:lu)endo-ome
700	1	a Molony, Cliona M.4 aut
700	1	a Nolte, Ilja M.4 aut
700	1	a Padmanabhan, Sandosh4 aut
700	1	a Price, Tom S.4 aut
700	1	a Rajagopalan, Ramakrishnan4 aut
700	1	a Shaffer, Jonathan4 aut
700	1	a Shah, Sonia4 aut
700	1	a Shen, Haiqing4 aut
700	1	a Soranzo, Nicole4 aut
700	1	a van der Most, Peter J.4 aut
700	1	a Van Iperen, Erik P. A.4 aut
700	1	a Van Setten, Jessic A.4 aut
700	1	a Vonk, Judith M.4 aut
700	1	a Zhang, Li4 aut
700	1	a Beitelshees, Amber L.4 aut
700	1	a Berenson, Gerald S.4 aut
700	1	a Bhatt, Deepak L.4 aut
700	1	a Boer, Jolanda M. A.4 aut
700	1	a Boerwinkle, Eric4 aut
700	1	a Burkley, Ben4 aut
700	1	a Burt, Amber4 aut
700	1	a Chakravarti, Aravinda4 aut
700	1	a Chen, Wei4 aut
700	1	a Cooper-DeHoff, Rhonda M.4 aut
700	1	a Curtis, Sean P.4 aut
700	1	a Dreisbach, Albert4 aut
700	1	a Duggan, David4 aut
700	1	a Ehret, Georg B.4 aut
700	1	a Fabsitz, Richard R.4 aut
700	1	a Fornage, Myriam4 aut
700	1	a Fox, Ervin4 aut
700	1	a Furlong, Clement E.4 aut
700	1	a Gansevoort, Ron T.4 aut
700	1	a Hofker, Marten H.4 aut
700	1	a Hovingh, G. Kees4 aut
700	1	a Kirkland, Susan A.4 aut
700	1	a Kottke-Marchant, Kandice4 aut
700	1	a Kutlar, Abdullah4 aut
700	1	a LaCroix, Andrea Z.4 aut
700	1	a Langaee, Taimour Y.4 aut
700	1	a Li, Yun R.4 aut
700	1	a Lin, Honghuang4 aut
700	1	a Liu, Kiang4 aut
700	1	a Maiwald, Steffi4 aut
700	1	a Malik, Rainer4 aut
700	1	a Murugesan, Gurunathan4 aut
700	1	a Newton-Cheh, Christopher4 aut
700	1	a OConnell, Jeffery R.4 aut
700	1	a Onland-Moret, N. Charlotte4 aut
700	1	a Ouwehand, Willem H.4 aut
700	1	a Palmas, Walter4 aut
700	1	a Penninx, Brenda W.4 aut
700	1	a Pepine, Carl J.4 aut
700	1	a Pettinger, Mary4 aut
700	1	a Polak, Joseph F.4 aut
700	1	a Ramachandran, Vasan S.4 aut
700	1	a Ranchalis, Jane4 aut
700	1	a Redline, Susan4 aut
700	1	a Ridker, Paul M.4 aut
700	1	a Rose, Lynda M.4 aut
700	1	a Scharnag, Hubert4 aut
700	1	a Schork, Nicholas J.4 aut
700	1	a Shimbo, Daichi4 aut
700	1	a Shuldiner, Alan R.4 aut
700	1	a Srinivasan, Sathanur R.4 aut
700	1	a Stolk, Ronald P.4 aut
700	1	a Taylor, Herman A.4 aut
700	1	a Thorand, Barbara4 aut
700	1	a Trip, Mieke D.4 aut
700	1	a van Duijn, Cornelia M.4 aut
700	1	a Verschuren, W. Monique4 aut
700	1	a Wijmenga, Cisca4 aut
700	1	a Winkelmann, Bernhard R.4 aut
700	1	a Wyatt, Sharon4 aut
700	1	a Young, J. Hunter4 aut
700	1	a Boehm, Bernhard O.4 aut
700	1	a Caulfield, Mark J.4 aut
700	1	a Chasman, Daniel I.4 aut
700	1	a Davidson, Karina W.4 aut
700	1	a Doevendans, Pieter A.4 aut
700	1	a FitzGerald, Garret A.4 aut
700	1	a Gums, John G.4 aut
700	1	a Hakonarson, Hakon4 aut
700	1	a Hillege, Hans L.4 aut
700	1	a Illig, Thomas4 aut
700	1	a Jarvik, Gail P.4 aut
700	1	a Johnson, Julie A.4 aut
700	1	a Kastelein, John J. P.4 aut
700	1	a Koenig, Wolfgang4 aut
700	1	a Maerz, Winfried4 aut
700	1	a Mitchell, Braxton D.4 aut
700	1	a Murray, Sarah S.4 aut
700	1	a Oldehinkel, Albertine J.4 aut
700	1	a Rader, Daniel J.4 aut
700	1	a Reilly, Muredach P.4 aut
700	1	a Reiner, Alex P.4 aut
700	1	a Schadt, Eric E.4 aut
700	1	a Silverstein, Roy L.4 aut
700	1	a Snieder, Harold4 aut
700	1	a Stanton, Alice V.4 aut
700	1	a Uitterlinden, Andre G.4 aut
700	1	a van der Harst, Pim4 aut
700	1	a van der Schouw, Yvonne T.4 aut
700	1	a Samani, Nilesh J.4 aut
700	1	a Johnson, Andrew D.4 aut
700	1	a Munroe, Patricia B.4 aut
700	1	a de Bakker, Paul I. W.4 aut
700	1	a Zhu, Xiaofeng4 aut
700	1	a Levy, Daniel4 aut
700	1	a Keating, Brendan J.4 aut
700	1	a Asselbergs, Folkert W.4 aut
710	2	a Kardiovaskulär forskning - hypertonib Forskargrupper vid Lunds universitet4 org
773	0	t Human Molecular Geneticsd : Oxford University Press (OUP)g 22:8, s. 1663-1678q 22:8<1663-1678x 0964-6906x 1460-2083
856	4	u http://dx.doi.org/10.1093/hmg/dds555y FULLTEXT
856	4	u https://academic.oup.com/hmg/article-pdf/22/8/1663/14140725/dds555.pdf
856	4 8	u https://lup.lub.lu.se/record/3748324
856	4 8	u https://doi.org/10.1093/hmg/dds555

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Av författaren/redakt...: Ganesh, Santhi K ...; Tragante, Vinici ...; Guo, Wei; Guo, Yiran; Lanktree, Matthe ...; Smith, Erin N.; visa fler...; Johnson, Toby; Castillo, Berta ...; Barnard, John; Baumert, Jens; Chang, Yen-Pei C ...; Elbers, Clara C.; Farrall, Martin; Fischer, Mary E.; Franceschini, No ...; Gaunt, Tom R.; Gho, Johannes M. ...; Gieger, Christia ...; Gong, Yan; Isaacs, Aaron; Kleber, Marcus E ...; Leach, Irene Mat ...; McDonough, Caitr ...; Meijs, Matthijs ...; Melander, Olle; Molony, Cliona M ...; Nolte, Ilja M.; Padmanabhan, San ...; Price, Tom S.; Rajagopalan, Ram ...; Shaffer, Jonatha ...; Shah, Sonia; Shen, Haiqing; Soranzo, Nicole; van der Most, Pe ...; Van Iperen, Erik ...; Van Setten, Jess ...; Vonk, Judith M.; Zhang, Li; Beitelshees, Amb ...; Berenson, Gerald ...; Bhatt, Deepak L.; Boer, Jolanda M. ...; Boerwinkle, Eric; Burkley, Ben; Burt, Amber; Chakravarti, Ara ...; Chen, Wei; Cooper-DeHoff, R ...; Curtis, Sean P.; Dreisbach, Alber ...; Duggan, David; Ehret, Georg B.; Fabsitz, Richard ...; Fornage, Myriam; Fox, Ervin; Furlong, Clement ...; Gansevoort, Ron ...; Hofker, Marten H ...; Hovingh, G. Kees; Kirkland, Susan ...; Kottke-Marchant, ...; Kutlar, Abdullah; LaCroix, Andrea ...; Langaee, Taimour ...; Li, Yun R.; Lin, Honghuang; Liu, Kiang; Maiwald, Steffi; Malik, Rainer; Murugesan, Gurun ...; Newton-Cheh, Chr ...; OConnell, Jeffer ...; Onland-Moret, N. ...; Ouwehand, Willem ...; Palmas, Walter; Penninx, Brenda ...; Pepine, Carl J.; Pettinger, Mary; Polak, Joseph F.; Ramachandran, Va ...; Ranchalis, Jane; Redline, Susan; Ridker, Paul M.; Rose, Lynda M.; Scharnag, Hubert; Schork, Nicholas ...; Shimbo, Daichi; Shuldiner, Alan ...; Srinivasan, Sath ...; Stolk, Ronald P.; Taylor, Herman A ...; Thorand, Barbara; Trip, Mieke D.; van Duijn, Corne ...; Verschuren, W. M ...; Wijmenga, Cisca; Winkelmann, Bern ...; Wyatt, Sharon; Young, J. Hunter; Boehm, Bernhard ...; Caulfield, Mark ...; Chasman, Daniel ...; Davidson, Karina ...; Doevendans, Piet ...; FitzGerald, Garr ...; Gums, John G.; Hakonarson, Hako ...; Hillege, Hans L.; Illig, Thomas; Jarvik, Gail P.; Johnson, Julie A ...; Kastelein, John ...; Koenig, Wolfgang; Maerz, Winfried; Mitchell, Braxto ...; Murray, Sarah S.; Oldehinkel, Albe ...; Rader, Daniel J.; Reilly, Muredach ...; Reiner, Alex P.; Schadt, Eric E.; Silverstein, Roy ...; Snieder, Harold; Stanton, Alice V ...; Uitterlinden, An ...; van der Harst, P ...; van der Schouw, ...; Samani, Nilesh J ...; Johnson, Andrew ...; Munroe, Patricia ...; de Bakker, Paul ...; Zhu, Xiaofeng; Levy, Daniel; Keating, Brendan ...; Asselbergs, Folk ...; visa färre...

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