The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial

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Fältnamn	Indikatorer	Metadata
000		04100naa a2200613 4500
001		oai:gup.ub.gu.se/318176
003		SwePub
008		240528s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://gup.ub.gu.se/publication/3181762 URI
024	7	a https://doi.org/10.1007/s00586-022-07317-52 DOI
040		a (SwePub)gu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Aaen, J.4 aut
245	1 0	a The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial
264		c 2022-08-05
264	1	b Springer Science and Business Media LLC,c 2022
520		a Purpose To investigate potential associations between preoperative MRI findings and patient reported outcome measures (PROMs) after surgery for lumbar spinal stenosis (LSS). Methods The NORDSTEN trial included 437 patients. We investigated the association between preoperative MRI findings such as morphological grade of stenosis (Schizas grade), quantitative grade of stenosis (dural sac cross-sectional area), disc degeneration (Pfirrmann score), facet joint tropism and fatty infiltration of the multifidus muscle, and improvement in patient reported outcome measures (PROMs) 2 years after surgery. We dichotomized each radiological parameter into a moderate or severe category. PROMs i.e., Oswestry Disability Index (ODI), Zurich Claudication Questionnaire (ZCQ) and Numeric rating scale (NRS) for back and leg pain were collected before surgery and at 2 year follow-up. In the primary analysis, we investigated the association between MRI findings and ODI score (dichotomized to >= 30% improvement or not). In the secondary analysis, we investigated the association between MRI findings and the mean improvement on the ODI-, ZCQ- and NRS scores. We used multivariable regression models adjusted for patients' gender, age, smoking status and BMI. Results The primary analysis showed that severe disc degeneration (Pfirrmann score 4-5) was significantly associated with less chance of achieving a 30% improvement on the ODI score (OR 0.54, 95% CI 0.34, 0.88). In the secondary analysis, we detected no clinical relevant associations. Conclusion Severe disc degeneration preoperatively suggest lesser chance of achieving 30% improvement in ODI score after surgery for LSS. Other preoperative MRI findings were not associated with patient reported outcome.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
653		a Lumbar spinal stenosis
653		a PROMS
653		a MRI
653		a Pfirrmann
653		a Schizas
653		a dural sac
653		a lumbar
653		a surgery
653		a pain
653		a disability
653		a decompression
653		a predictors
653		a severity
653		a tropism
653		a Neurosciences & Neurology
653		a Orthopedics
700	1	a Banitalebi, H.4 aut
700	1	a Austevoll, I. M.4 aut
700	1	a Hellum, C.4 aut
700	1	a Storheim, K.4 aut
700	1	a Myklebust, T. A.4 aut
700	1	a Anvar, M.4 aut
700	1	a Weber, C.4 aut
700	1	a Solberg, T.4 aut
700	1	a Grundnes, O.4 aut
700	1	a Brisby, Helena,d 1965u Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för ortopedi,Institute of Clinical Sciences, Department of Orthopaedics4 aut0 (Swepub:gu)xbrish
700	1	a Indrekvam, K.4 aut
700	1	a Hermansen, E.4 aut
710	2	a Göteborgs universitetb Institutionen för kliniska vetenskaper, Avdelningen för ortopedi4 org
773	0	t European Spine Journald : Springer Science and Business Media LLCg 31:10, s. 2777-2785q 31:10<2777-2785x 0940-6719x 1432-0932
856	4 8	u https://gup.ub.gu.se/publication/318176
856	4 8	u https://doi.org/10.1007/s00586-022-07317-5

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Av författaren/redakt...: Aaen, J.; Banitalebi, H.; Austevoll, I. M.; Hellum, C.; Storheim, K.; Myklebust, T. A.; visa fler...; Anvar, M.; Weber, C.; Solberg, T.; Grundnes, O.; Brisby, Helena, ...; Indrekvam, K.; Hermansen, E.; visa färre...

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