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A Deletion in the Canine POMC Gene Is Associated with Weight and Appetite in Obesity-Prone Labrador Retriever Dogs

Raffan, Eleanor (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Dennis, Rowena J. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
O'Donovan, Conor J. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
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Becker, Julia M. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Scott, Robert A. (author)
Univ Cambridge, WT MRC Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England.
Smith, Stephen P. (author)
Univ Cambridge, Sch Clin Med, Cambridge CB2 0SP, England.
Withers, David J. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Wood, Claire J. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Conci, Elena (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Clements, Dylan N. (author)
Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland.;Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush EH25 9RG, Midlothian, Scotland.
Summers, Kim M. (author)
Univ Edinburgh, Roslin Inst, Easter Bush EH25 9RG, Midlothian, Scotland.
German, Alexander J. (author)
Univ Liverpool, Inst Ageing & Chron Dis, Neston CH64 7TE, Cheshire, England.
Mellersh, Cathryn S. (author)
Anim Hlth Trust, Dept Canine Genet, Newmarket CB8 7UU, Suffolk, England.
Arendt, Maja L. (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
Iyemere, Valentine P. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Withers, Elaine (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
Söder, Josefin (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden.
Wernersson, Sara (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för anatomi, fysiologi och biokemi,Department of Anatomy, Physiology and Biochemistry (AFB),Swedish Univ Agr Sci, Dept Anat Physiol & Biochem, S-75007 Uppsala, Sweden.
Andersson, Göran (author)
Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, S-75007 Uppsala, Sweden.
Lindblad-Toh, Kerstin (author)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Broad Inst Harvard & MIT, Cambridge, MA 02142 USA.
Yeo, Giles S. H. (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
O'Rahilly, Stephen (author)
Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England.
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Univ Cambridge, WT MRC Inst Metab Sci, Metab Res Labs, Cambridge CB2 0QQ, England Univ Cambridge, WT MRC Inst Metab Sci, MRC Epidemiol Unit, Cambridge CB2 0QQ, England. (creator_code:org_t)
 
Elsevier BV, 2016
2016
English.
In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 23:5, s. 893-900
Related links:
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Sequencing of candidate genes for obesity in Labrador retriever dogs identified a 14 bp deletion in pro-opiomelanocortin (POMC) with an allele frequency of 12%. The deletion disrupts the b-MSH and beta-endorphin coding sequences and is associated with body weight (per allele effect of 0.33 SD), adiposity, and greater food motivation. Among other dog breeds, the deletion was only found in the closely related flat-coat retriever (FCR), where it is similarly associated with body weight and food motivation. The mutation is significantly more common in Labrador retrievers selected to become assistance dogs than pets. In conclusion, the deletion in POMC is a significant modifier of weight and appetite in Labrador retrievers and FCRs and may influence other behavioral traits.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
LANTBRUKSVETENSKAPER  -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
AGRICULTURAL SCIENCES  -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
LANTBRUKSVETENSKAPER  -- Husdjursvetenskap -- Husdjursvetenskap (hsv//swe)
AGRICULTURAL SCIENCES  -- Animal and Dairy Sience -- Animal and Dairy Science. (hsv//eng)

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