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Prediagnostic selen...
Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
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Hughes, David J. (author)
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Duarte-Salles, Talita (author)
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Hybsier, Sandra (author)
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Trichopoulou, Antonia (author)
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Stepien, Magdalena (author)
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Aleksandrova, Krasimira (author)
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Overvad, Kim (author)
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Tjonneland, Anne (author)
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Olsen, Anja (author)
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Affret, Aurelie (author)
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Fagherazzi, Guy (author)
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Boutron-Ruault, Marie-Christine (author)
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Katzke, Verena (author)
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Kaaks, Rudolf (author)
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Boeing, Heiner (author)
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Bamia, Christina (author)
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Lagiou, Pagona (author)
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Peppa, Eleni (author)
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Palli, Domenico (author)
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Krogh, Vittorio (author)
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Panico, Salvatore (author)
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Tumino, Rosario (author)
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Sacerdote, Carlotta (author)
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Bueno-de-Mesquita, Hendrik Bastiaan (author)
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Peeters, Petra H. (author)
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Engeset, Dagrun (author)
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- Weiderpass, Elisabete (author)
- Karolinska Institutet
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Lasheras, Cristina (author)
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Agudo, Antonio (author)
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Sanchez, Maria-Jose (author)
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Navarro, Carmen (author)
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Ardanaz, Eva (author)
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Dorronsoro, Miren (author)
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- Hemmingsson, Oskar (author)
- Umeå universitet,Kirurgi
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Wareham, Nicholas J. (author)
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Khaw, Kay-Tee (author)
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Bradbury, Kathryn E. (author)
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Cross, Amanda J. (author)
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Gunter, Marc (author)
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Riboli, Elio (author)
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Romieu, Isabelle (author)
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Schomburg, Lutz (author)
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Jenab, Mazda (author)
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(creator_code:org_t)
- Elsevier BV, 2016
- 2016
- English.
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In: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 104:2, s. 406-414
- Related links:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Subject headings
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- Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract.Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression.Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend <= 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63).Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- hepatocellular carcinoma
- selenium
- selenoprotein P
- prospective cohort
- liver cancer
- hepatobiliary ncer
- selenium status
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hughes, David J.
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Duarte-Salles, T ...
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Hybsier, Sandra
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Trichopoulou, An ...
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Stepien, Magdale ...
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Aleksandrova, Kr ...
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show more...
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Overvad, Kim
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Tjonneland, Anne
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Olsen, Anja
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Affret, Aurelie
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Fagherazzi, Guy
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Boutron-Ruault, ...
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Katzke, Verena
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Kaaks, Rudolf
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Boeing, Heiner
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Bamia, Christina
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Lagiou, Pagona
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Peppa, Eleni
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Palli, Domenico
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Krogh, Vittorio
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Engeset, Dagrun
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Weiderpass, Elis ...
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Lasheras, Cristi ...
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Agudo, Antonio
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Sanchez, Maria-J ...
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Navarro, Carmen
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Ardanaz, Eva
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Dorronsoro, Mire ...
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Hemmingsson, Osk ...
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Wareham, Nichola ...
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Khaw, Kay-Tee
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Bradbury, Kathry ...
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Cross, Amanda J.
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Gunter, Marc
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Riboli, Elio
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Romieu, Isabelle
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Schomburg, Lutz
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Jenab, Mazda
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Nutrition and Di ...
- Articles in the publication
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American Journal ...
- By the university
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Umeå University
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Karolinska Institutet