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(swepub) lar1:(umu) pers:(Riboli Elio) pers:(Krogh Vittorio) pers:(Navarro Carmen) pers:(Khaw Kay Tee)
 

Search: (swepub) lar1:(umu) pers:(Riboli Elio) pers:(Krogh Vittorio) pers:(Navarro Carmen) pers:(Khaw Kay Tee) > Prediagnostic selen...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005404naa a2200937 4500
001oai:DiVA.org:umu-126626
003SwePub
008161012s2016 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:134044230
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1266262 URI
0247 a https://doi.org/10.3945/ajcn.116.1316722 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1340442302 URI
040 a (SwePub)umud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hughes, David J.4 aut
2451 0a Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort
264 1b Elsevier BV,c 2016
338 a print2 rdacarrier
520 a Background: Selenium status is suboptimal in many Europeans and may be a risk factor for the development of various cancers, including those of the liver and biliary tract.Objective: We wished to examine whether selenium status in advance of cancer onset is associated with hepatobiliary cancers in the EPIC (European Prospective Investigation into Cancer and Nutrition) study.Design: We assessed prediagnostic selenium status by measuring serum concentrations of selenium and selenoprotein P (SePP; the major circulating selenium transfer protein) and examined the association with hepatocellular carcinoma (HCC; n = 121), gallbladder and biliary tract cancers (GBTCs; n = 100), and intrahepatic bile duct cancer (IHBC; n = 40) risk in a nested case-control design within the EPIC study. Selenium was measured by total reflection X-ray fluorescence, and SePP was determined by a colorimetric sandwich ELISA. Multivariable ORs and 95% CIs were calculated by using conditional logistic regression.Results: HCC and GBTC cases, but not IHBC cases, showed significantly lower circulating selenium and SePP concentrations than their matched controls. Higher circulating selenium was associated with a significantly lower HCC risk (OR per 20-mg/L increase: 0.41; 95% CI: 0.23, 0.72) but not with the risk of GBTC or IHBC. Similarly, higher SePP concentrations were associated with lowered HCC risk only in both the categorical and continuous analyses (HCC: P-trend <= 0.0001; OR per 1.5-mg/L increase: 0.37; 95% CI: 0.21, 0.63).Conclusion: These findings from a large prospective cohort provide evidence that suboptimal selenium status in Europeans may be associated with an appreciably increased risk of HCC development.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653 a hepatocellular carcinoma
653 a selenium
653 a selenoprotein P
653 a prospective cohort
653 a liver cancer
653 a hepatobiliary ncer
653 a selenium status
7001 a Duarte-Salles, Talita4 aut
7001 a Hybsier, Sandra4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Stepien, Magdalena4 aut
7001 a Aleksandrova, Krasimira4 aut
7001 a Overvad, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Olsen, Anja4 aut
7001 a Affret, Aurelie4 aut
7001 a Fagherazzi, Guy4 aut
7001 a Boutron-Ruault, Marie-Christine4 aut
7001 a Katzke, Verena4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Boeing, Heiner4 aut
7001 a Bamia, Christina4 aut
7001 a Lagiou, Pagona4 aut
7001 a Peppa, Eleni4 aut
7001 a Palli, Domenico4 aut
7001 a Krogh, Vittorio4 aut
7001 a Panico, Salvatore4 aut
7001 a Tumino, Rosario4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Bueno-de-Mesquita, Hendrik Bastiaan4 aut
7001 a Peeters, Petra H.4 aut
7001 a Engeset, Dagrun4 aut
7001 a Weiderpass, Elisabeteu Karolinska Institutet4 aut
7001 a Lasheras, Cristina4 aut
7001 a Agudo, Antonio4 aut
7001 a Sanchez, Maria-Jose4 aut
7001 a Navarro, Carmen4 aut
7001 a Ardanaz, Eva4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Hemmingsson, Oskaru Umeå universitet,Kirurgi4 aut0 (Swepub:umu)osrhen96
7001 a Wareham, Nicholas J.4 aut
7001 a Khaw, Kay-Tee4 aut
7001 a Bradbury, Kathryn E.4 aut
7001 a Cross, Amanda J.4 aut
7001 a Gunter, Marc4 aut
7001 a Riboli, Elio4 aut
7001 a Romieu, Isabelle4 aut
7001 a Schomburg, Lutz4 aut
7001 a Jenab, Mazda4 aut
7102 a Karolinska Institutetb Kirurgi4 org
7730 t American Journal of Clinical Nutritiond : Elsevier BVg 104:2, s. 406-414q 104:2<406-414x 0002-9165x 1938-3207
8564 u https://academic.oup.com/ajcn/article-pdf/104/2/406/23773379/ajcn131672.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126626
8564 8u https://doi.org/10.3945/ajcn.116.131672
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:134044230

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