Search: AMNE:(MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Reumatologi och inflammation)
> (2020-2024) >
Presence and immuno...
Presence and immunoreactivity of Aggregatibacter actinomycetemcomitans in rheumatoid arthritis
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- Svärd, Anna (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Uppsala Univ, Sweden
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- Lo Martire, Riccardo (author)
- Högskolan Dalarna,Medicinsk vetenskap,Center for Clinical Research Dalarna, Uppsala University, Falun,Uppsala Univ, Sweden; Dalarna Univ, Sweden
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- Martinsson, Klara (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Öhman, Carina (author)
- Department of Odontology, Umeå University, 901 87 Umeå, Sweden,Umea Univ, Sweden
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- Kastbom, Alf (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland
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- Johansson, Anders (author)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen,Umeå University, Umeå,Umea Univ, Sweden
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(creator_code:org_t)
- MDPI, 2024
- 2024
- English.
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In: Pathogens. - : MDPI. - 2076-0817. ; 13:5, s. 368-368
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https://umu.diva-por... (primary) (Raw object)
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https://du.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- The presence of periodontal pathogens is associated with an increased prevalence of rheumatoid arthritis (RA). The systemic antibody response to epitopes of these bacteria is often used asa proxy to study correlations between bacteria and RA. The primary aim of the present study is toexamine the correlation between the presence of Aggregatibacter actinomycetemcomitans (Aa) in theoral cavity and serum antibodies against the leukotoxin (LtxA) produced by this bacterium. Thesalivary presence of Aa was analyzed with quantitative PCR and serum LtxA ab in a cell culturebased neutralization assay. The analyses were performed on samples from a well-characterized RAcohort (n = 189) and a reference population of blood donors (n = 101). Salivary Aa was present in15% of the RA patients and 6% of the blood donors. LtxA ab were detected in 19% of RA-sera andin 16% of sera from blood donors. The correlation between salivary Aa and serum LtxA ab wassurprisingly low (rho = 0.55 [95% CI: 0.40, 0.68]). The presence of salivary Aa showed no significantassociation with any of the RA-associated parameters documented in the cohort. A limitation of thepresent study is the relatively low number of individuals with detectable concentrations of Aa insaliva. Moreover, in the comparison of detectable Aa prevalence between RA patients and blooddonors, we assumed that the two groups were equivalent in other Aa prognostic factors. These limitations must be taken into consideration when the result from the study is interpreted. We concludethat a systemic immune response to Aa LtxA does not fully reflect the prevalence of Aa in saliva. Inaddition, the association between RA-associated parameters and the presence of Aa was negligiblein the present RA cohort.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Aggregatibacter actinomycetemcomitans
- salivary concentrations
- rheumatoid arthritis
- systemic biomarker
- reumatologi
- rheumatology
- Infectious Diseases
- infektionssjukdomar
Publication and Content Type
- ref (subject category)
- art (subject category)
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