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Autism spectrum dis...
Autism spectrum disorders and coexisting disorders in a nationwide Swedish twin study
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- Lundström, Sebastian (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Centrum för etik, juridik och mental hälsa,Gillberg Neuropsychiatry Centre,Centre for Ethics, Law, and Mental Health
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Reichenberg, Abraham (författare)
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- Melke, Jonas, 1971 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi,Institute of Neuroscience and Physiology, Department of Pharmacology
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- Råstam, Maria (författare)
- Lund University,Lunds universitet,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Kerekes, Nora, 1969 (författare)
- Gothenburg University,Göteborgs universitet,Centrum för etik, juridik och mental hälsa,Centre for Ethics, Law, and Mental Health
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- Lichtenstein, Paul (författare)
- Karolinska Institutet
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- Gillberg, Christopher, 1950 (författare)
- Gothenburg University,Göteborgs universitet,Gillbergcentrum,Gillberg Neuropsychiatry Centre
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- Anckarsäter, Henrik (författare)
- Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Rättspsykiatri, Malmö,Forskargrupper vid Lunds universitet,Forensic Psychiatry, Malmö,Lund University Research Groups,Centrum för etik, juridik och mental hälsa,Centre for Ethics, Law, and Mental Health
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- ISSN 0021-9630
- 2014-10-03
- 2015
- Engelska.
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Ingår i: Journal of Child Psychology and Psychiatry and Allied Disciplines. - Stockholm : Wiley. - 0021-9630 .- 1469-7610. ; 56:6, s. 702-710
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Abstract
Ämnesord
Stäng
- Background: Evidence from twin and molecular genetic studies is accumulating that Autism Spectrum Disorder (ASD) shares substantial etiological factors with other disorders. This is mirrored in clinical practice where ASD without coexisting disorders is rare. The present study aims to examine the range of coexisting disorders in ASD in a genetically informative cohort. Methods: Parents of all Swedish 9-year-old twins born between 1992 and 2001 (n = 19,130) underwent a telephone interview designed to screen for child psychiatric disorders, including ASD. To ensure full coverage of child psychiatric disorders, data were also retrieved from population-based health registers. We investigated the coexistence of eight psychiatric disorders known to coexist with ASDs in probands and their co-twins. Results: Half of the individuals with ASDs (50.3%) had four or more coexisting disorders and only 4% did not have any concomitant disorder. The ‘healthy co-twin’ in ASD discordant monozygotic twin pairs was very often (79% of boys and 50% of girls) affected by at least one non-ASD disorder. The corresponding figures for ASD discordant dizygotic twin pairs were significantly lower (46% of males and 30% of females). Conclusions: Detailed phenotypic descriptions including symptoms of problems associated with a wide range of child psychiatric disorders may aid in unraveling the genetic architecture of ASD and should guide the development of intervention strategies addressing each problem type specifically.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Nyckelord
- Autism spectrum disorders
- comorbidity
- genetics
- twins
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- art (ämneskategori)
- ref (ämneskategori)
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Lundström, Sebas ...
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Reichenberg, Abr ...
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Melke, Jonas, 19 ...
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Råstam, Maria
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Kerekes, Nora, 1 ...
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Lichtenstein, Pa ...
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Gillberg, Christ ...
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Anckarsäter, Hen ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Psykiatri
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Journal of Child ...
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Lunds universitet
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Karolinska Institutet
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Göteborgs universitet