Sökning: L773:0026 0495 > Oscillatory Ca2+ si...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 02816naa a2200313 4500 | |
001 | oai:DiVA.org:uu-52970 | |
003 | SwePub | |
008 | 081017s1997 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-529702 URI |
024 | 7 | a https://doi.org/10.1016/S0026-0495(97)90048-22 DOI |
040 | a (SwePub)uu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Berts, Alfu Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
245 | 1 0 | a Oscillatory Ca2+ signaling in somatostatin-producing cells from the human pancreas |
264 | 1 | c 1997 |
338 | a print2 rdacarrier | |
520 | a Oscillatory Ca2+ signaling was studied in human somatostatin-releasing pancreatic δ cells identified by immunostaining. A ratiometric fura-2 technique was used for measuring cytoplasmic concentrations of Ca2+ and Sr2+ in δ cells exposed to the respective cation. Rhythmic activity in terms of slow (frequency, 0.1 to 0.4 per minute) oscillations from close to the basal level was seen in the presence of 3 to 20 mmol/L glucose during superfusion with medium containing 2.6 to 5 mmol/L Ca2+ or 5 mmol/L Sr2. These oscillations could be transformed into a sustained increase by decreasing extracellular Ca2+ or adding 1 mmol/L tolbutamide or 20 nmol/L glucagon. Addition of glucagon to a medium containing 20 mmol/L glucose resulted in the generation of short (< 30 seconds) transients, which disappeared upon exposure to 100 nmol/L of the intracellular Ca2+-adenosine triphosphatase (ATPase) inhibitor thapsigargin. When analyzing small aggregates of islet cells, it became evident that oscillatory activity in δ cells can be synchronous with that in adjacent non—δ cells. It is concluded that secretion of pancreatic somatostatin in man involves Ca2+ signaling similar to that regulating the pulsatile release of insulin. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Cell- och molekylärbiologi0 (SwePub)301082 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Cell and Molecular Biology0 (SwePub)301082 hsv//eng |
700 | 1 | a Liu, Yi-Jiau Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut |
700 | 1 | a Gylfe, Erik,d 1947-u Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)erikgylf |
700 | 1 | a Hellman, Bou Uppsala universitet,Institutionen för medicinsk cellbiologi4 aut0 (Swepub:uu)bhe25105 |
710 | 2 | a Uppsala universitetb Institutionen för medicinsk cellbiologi4 org |
773 | 0 | t Metabolismg 46:4, s. 366-369q 46:4<366-369x 0026-0495x 1532-8600 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-52970 |
856 | 4 8 | u https://doi.org/10.1016/S0026-0495(97)90048-2 |
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